Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformis

2.50
Hdl Handle:
http://hdl.handle.net/2336/11211
Title:
Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformis
Authors:
Omarsdottir, Sesselja; Freysdottir, Jona; Olafsdottir, Elin Soffia
Citation:
Phytomedicine 2007, 14(2-3):179-84
Issue Date:
1-Feb-2007
Abstract:
Three heteroglycans Ths-4, Ths-5 and thamnolan and a beta-glucan, Ths-2, isolated from the lichen Thamnolia vermicularis var. subuliformis were tested for in vitro immunomodulating activities and shown to have various influences on the immune system. All the polysaccharides except Ths-4 caused a stimulation of rat spleen cell proliferation. In contrast, Ths-4 caused cell death early in the culture, probably due to over-stimulation. Moreover, the galactofuranomannans, Ths-4, Ths-5 and the beta-glucan Ths-2, induced rat spleen cells to secrete IL-10 significantly above background levels. In addition, Ths-4 and Ths-5 stimulated significant TNF-alpha secretion by rat peritoneal macrophages. The galactofuranomannans Ths-4 and Ths-5 have similar structures apart from the molecular weight. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. The galactofuranorhamnan thamnolan had less mitogenic effect than Ths-5 and Ths-2 and neither induced IL-10 secretion by rat spleen cells nor TNF-alpha secretion by peritoneal macrophages to significant levels. This shows that thamnolan with its unusual galactofuranorhamnan structure differs from the other Thamnolia polysaccharides in its immunomodulatory activity.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.phymed.2006.11.012

Full metadata record

DC FieldValue Language
dc.contributor.authorOmarsdottir, Sesselja-
dc.contributor.authorFreysdottir, Jona-
dc.contributor.authorOlafsdottir, Elin Soffia-
dc.date.accessioned2007-04-17T08:41:00Z-
dc.date.available2007-04-17T08:41:00Z-
dc.date.issued2007-02-01-
dc.date.submitted2006-04-17-
dc.identifier.citationPhytomedicine 2007, 14(2-3):179-84en
dc.identifier.issn0944-7113-
dc.identifier.pmid17222542-
dc.identifier.doi10.1016/j.phymed.2006.11.012-
dc.identifier.otherRHE12-
dc.identifier.urihttp://hdl.handle.net/2336/11211-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThree heteroglycans Ths-4, Ths-5 and thamnolan and a beta-glucan, Ths-2, isolated from the lichen Thamnolia vermicularis var. subuliformis were tested for in vitro immunomodulating activities and shown to have various influences on the immune system. All the polysaccharides except Ths-4 caused a stimulation of rat spleen cell proliferation. In contrast, Ths-4 caused cell death early in the culture, probably due to over-stimulation. Moreover, the galactofuranomannans, Ths-4, Ths-5 and the beta-glucan Ths-2, induced rat spleen cells to secrete IL-10 significantly above background levels. In addition, Ths-4 and Ths-5 stimulated significant TNF-alpha secretion by rat peritoneal macrophages. The galactofuranomannans Ths-4 and Ths-5 have similar structures apart from the molecular weight. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. The galactofuranorhamnan thamnolan had less mitogenic effect than Ths-5 and Ths-2 and neither induced IL-10 secretion by rat spleen cells nor TNF-alpha secretion by peritoneal macrophages to significant levels. This shows that thamnolan with its unusual galactofuranorhamnan structure differs from the other Thamnolia polysaccharides in its immunomodulatory activity.en
dc.language.isoenen
dc.publisherUrban & Fischer Verlagen
dc.relation.urlhttp://dx.doi.org/10.1016/j.phymed.2006.11.012en
dc.subject.meshAnimalsen
dc.subject.meshCell Proliferationen
dc.subject.meshCells, Cultureden
dc.subject.meshEnzyme-Linked Immunosorbent Assayen
dc.subject.meshImmune Systemen
dc.subject.meshImmunologic Factorsen
dc.subject.meshInterleukin-10en
dc.subject.meshLichensen
dc.subject.meshMacrophages, Peritonealen
dc.subject.meshPhytotherapyen
dc.subject.meshPlant Extractsen
dc.subject.meshPolysaccharidesen
dc.subject.meshRatsen
dc.subject.meshSpleenen
dc.subject.meshTumor Necrosis Factor-alphaen
dc.titleImmunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformisen
dc.typeArticleen
dc.identifier.journalPhytomedicine : international journal of phytotherapy and phytopharmacologyen
dc.format.digYES-

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