Clinical experience of urine D-arabinitol/L-arabinitol ratio in the early diagnosis of invasive candidiasis in paediatric high risk populations

2.50
Hdl Handle:
http://hdl.handle.net/2336/11233
Title:
Clinical experience of urine D-arabinitol/L-arabinitol ratio in the early diagnosis of invasive candidiasis in paediatric high risk populations
Authors:
Sigmundsdottir, Gudrun; Larsson, Lennart; Wiebe, Thomas; Björklund, Lars J; Christensson, Bertil
Citation:
Scand. J. Infect. Dis. 2007, 39(2):146-51
Issue Date:
2-Feb-2007
Abstract:
In 2 prospective studies, we previously reported on the early and accurate diagnosis of invasive candidiasis by determining the D-arabinitol/L-arabinitol (DA/LA) ratio in urine in neutropenic children with cancer at the paediatric oncology unit (POU) and in premature infants at the neonatal intensive care unit (NICU) at our hospital. In this retrospective study at the same units, we report how the DA/LA assay was implemented in clinical practice immediately after the prospective study periods. We found that, in the POU, the recommendation of regularly monitoring urine DA/LA ratios in patients at risk and considering antifungal therapy in the case of elevated ratios had been followed. A significant decrease in the incidence of culture positive invasive candidiasis may have been attributed to the introduction of the DA/LA assay. At the NICU, where the DA/LA assay was recommended only as an adjunct to other diagnostic tools, morbidity in invasive candidiasis remained unchanged. While regular monitoring of the urine DA/LA ratio probably facilitates the early detection of invasive candidiasis in paediatric oncology, it remains to be determined if the test can be used in a similar way in neonatal intensive care.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.metapress.com/content/t2674142w2765476

Full metadata record

DC FieldValue Language
dc.contributor.authorSigmundsdottir, Gudrun-
dc.contributor.authorLarsson, Lennart-
dc.contributor.authorWiebe, Thomas-
dc.contributor.authorBjörklund, Lars J-
dc.contributor.authorChristensson, Bertil-
dc.date.accessioned2007-04-17T09:00:52Z-
dc.date.available2007-04-17T09:00:52Z-
dc.date.issued2007-02-02-
dc.date.submitted2007-04-17-
dc.identifier.citationScand. J. Infect. Dis. 2007, 39(2):146-51en
dc.identifier.issn0036-5548-
dc.identifier.pmid17366032-
dc.identifier.doi10.1080/00365540600951267-
dc.identifier.otherBAC12-
dc.identifier.urihttp://hdl.handle.net/2336/11233-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractIn 2 prospective studies, we previously reported on the early and accurate diagnosis of invasive candidiasis by determining the D-arabinitol/L-arabinitol (DA/LA) ratio in urine in neutropenic children with cancer at the paediatric oncology unit (POU) and in premature infants at the neonatal intensive care unit (NICU) at our hospital. In this retrospective study at the same units, we report how the DA/LA assay was implemented in clinical practice immediately after the prospective study periods. We found that, in the POU, the recommendation of regularly monitoring urine DA/LA ratios in patients at risk and considering antifungal therapy in the case of elevated ratios had been followed. A significant decrease in the incidence of culture positive invasive candidiasis may have been attributed to the introduction of the DA/LA assay. At the NICU, where the DA/LA assay was recommended only as an adjunct to other diagnostic tools, morbidity in invasive candidiasis remained unchanged. While regular monitoring of the urine DA/LA ratio probably facilitates the early detection of invasive candidiasis in paediatric oncology, it remains to be determined if the test can be used in a similar way in neonatal intensive care.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.metapress.com/content/t2674142w2765476en
dc.subject.meshSugar Alcoholsen
dc.subject.meshCandidiasisen
dc.subject.meshAntifungal Agentsen
dc.subject.meshIntensive Care Units, Neonatalen
dc.titleClinical experience of urine D-arabinitol/L-arabinitol ratio in the early diagnosis of invasive candidiasis in paediatric high risk populationsen
dc.typeArticleen
dc.identifier.journalScandinavian Journal of Infectious Diseasesen
dc.format.digYES-

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