What characterizes house dust mite sensitive individuals in a house dust mite free community in reykjavik, iceland?

2.50
Hdl Handle:
http://hdl.handle.net/2336/11248
Title:
What characterizes house dust mite sensitive individuals in a house dust mite free community in reykjavik, iceland?
Authors:
Adalsteinsdottir, Berglind; Sigurdardottir, Sigurveig Th; Gislason, Thorarinn; Kristensen, Bjarne; Gislason, David
Citation:
Allergol Int 2007, 56(1):51-6
Issue Date:
1-Mar-2007
Abstract:
Background: Previous studies show that 6-9% of young adults in Reykjavik are sensitised to the house dust mite (HDM) Dermatophagoides pteronyssinus (D. pteronyssinus). However, only negligible amounts of HDM and HDM allergens were detected in their homes. The study investigates what characterizes these individuals. Methods: We investigated all participants in the European Community Respiratory Health Surveys I and II (ECRHS I and II) with D. pteronyssinus specific IgE, in the years 1991-92. A grass positive but D. pteronyssinus negative control group was recruited from the same cohort. A detailed questionnaire was administered and the specific IgE (Pharmacia CAP system) against six D. pteronyssinus cross-reactive allergens was measured. Results: Of 601 ECRHS I participants with available IgE results, 88% returned for ECRHS II, 8.4 years later. Of 49 individuals with D. pteronyssinus specific IgE in ECRHS I, 24 had become negative in ECRHS II. Compared with controls, HDM sensitive subjects were more often men who had lived on farms or kept aquaria fish in childhood. Of those with specific IgE against D. pteronyssinus in ECRHS I and II, 75% had detectable IgE antibodies (>/=0.35kU/l) to cross-reactive allergens compared with none in the control group (p < 0.0001): Lepidoglyphus destructor (L. destructor) (67%), shrimp (58%), cockroach (33%), mosquito (17%), tropomyosin (17%) and blood worm (4%). Conclusions: Icelanders with specific IgE to D. pteronyssinus are more often men who spent time on farms in childhood and today have high prevalence of IgE antibodies cross-reactive to D. pteronyssinus.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ai.jsaweb.jp/fulltext/056010051/056010051_index.html

Full metadata record

DC FieldValue Language
dc.contributor.authorAdalsteinsdottir, Berglind-
dc.contributor.authorSigurdardottir, Sigurveig Th-
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorKristensen, Bjarne-
dc.contributor.authorGislason, David-
dc.date.accessioned2007-04-20T13:44:07Z-
dc.date.available2007-04-20T13:44:07Z-
dc.date.issued2007-03-01-
dc.date.submitted2007-04-20-
dc.identifier.citationAllergol Int 2007, 56(1):51-6en
dc.identifier.issn1323-8930-
dc.identifier.pmid17259810-
dc.identifier.doi10.2332/allergolint.O-06-447-
dc.identifier.urihttp://hdl.handle.net/2336/11248-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBackground: Previous studies show that 6-9% of young adults in Reykjavik are sensitised to the house dust mite (HDM) Dermatophagoides pteronyssinus (D. pteronyssinus). However, only negligible amounts of HDM and HDM allergens were detected in their homes. The study investigates what characterizes these individuals. Methods: We investigated all participants in the European Community Respiratory Health Surveys I and II (ECRHS I and II) with D. pteronyssinus specific IgE, in the years 1991-92. A grass positive but D. pteronyssinus negative control group was recruited from the same cohort. A detailed questionnaire was administered and the specific IgE (Pharmacia CAP system) against six D. pteronyssinus cross-reactive allergens was measured. Results: Of 601 ECRHS I participants with available IgE results, 88% returned for ECRHS II, 8.4 years later. Of 49 individuals with D. pteronyssinus specific IgE in ECRHS I, 24 had become negative in ECRHS II. Compared with controls, HDM sensitive subjects were more often men who had lived on farms or kept aquaria fish in childhood. Of those with specific IgE against D. pteronyssinus in ECRHS I and II, 75% had detectable IgE antibodies (>/=0.35kU/l) to cross-reactive allergens compared with none in the control group (p < 0.0001): Lepidoglyphus destructor (L. destructor) (67%), shrimp (58%), cockroach (33%), mosquito (17%), tropomyosin (17%) and blood worm (4%). Conclusions: Icelanders with specific IgE to D. pteronyssinus are more often men who spent time on farms in childhood and today have high prevalence of IgE antibodies cross-reactive to D. pteronyssinus.en
dc.language.isoenen
dc.publisherJapanese Society of Allergologyen
dc.relation.urlhttp://ai.jsaweb.jp/fulltext/056010051/056010051_index.htmlen
dc.subject.meshMitesen
dc.subject.meshIcelanden
dc.subject.meshEnvironmental Exposureen
dc.subject.meshDusten
dc.subject.meshImmunizationen
dc.subject.meshHypersensitivityen
dc.subject.meshPyroglyphidaeen
dc.subject.meshImmunoglobulin Een
dc.titleWhat characterizes house dust mite sensitive individuals in a house dust mite free community in reykjavik, iceland?en
dc.typeArticleen
dc.format.digYES-

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