2.50
Hdl Handle:
http://hdl.handle.net/2336/11283
Title:
Aurora-A amplification associated with BRCA2 mutation in breast tumours
Authors:
Bodvarsdottir, Sigridur K; Hilmarsdottir, Holmfridur; Birgisdottir, Valgerdur; Steinarsdottir, Margret; Jonasson, Jon G; Eyfjord, Jorunn E
Citation:
Cancer Lett. 2007, 248(1):96-102
Issue Date:
8-Apr-2007
Abstract:
Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p=0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0304-3835(06)00410-1

Full metadata record

DC FieldValue Language
dc.contributor.authorBodvarsdottir, Sigridur K-
dc.contributor.authorHilmarsdottir, Holmfridur-
dc.contributor.authorBirgisdottir, Valgerdur-
dc.contributor.authorSteinarsdottir, Margret-
dc.contributor.authorJonasson, Jon G-
dc.contributor.authorEyfjord, Jorunn E-
dc.date.accessioned2007-04-20T11:14:06Z-
dc.date.available2007-04-20T11:14:06Z-
dc.date.issued2007-04-08-
dc.date.submitted2007-04-20-
dc.identifier.citationCancer Lett. 2007, 248(1):96-102en
dc.identifier.issn0304-3835-
dc.identifier.pmid16860930-
dc.identifier.doi10.1016/j.canlet.2006.06.003-
dc.identifier.urihttp://hdl.handle.net/2336/11283-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPotential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p=0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment.en
dc.language.isoenen
dc.publisherElsevier Science Irelanden
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0304-3835(06)00410-1en
dc.subject.meshBreast Neoplasmsen
dc.subject.meshBRCA2 Proteinen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCell Lineen
dc.subject.meshDNA Mutational Analysisen
dc.subject.meshGene Amplificationen
dc.subject.meshMutationen
dc.subject.meshProtein-Serine-Threonine Kinasesen
dc.titleAurora-A amplification associated with BRCA2 mutation in breast tumoursen
dc.typeArticleen
dc.format.digYES-
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