2.50
Hdl Handle:
http://hdl.handle.net/2336/11287
Title:
The effects of smoking in pregnancy on factors influencing fetal growth
Authors:
Ingvarsson, Ragnar F; Bjarnason, Anton O; Dagbjartsson, Atli; Hardardottir, Hildur; Haraldsson, Asgeir; Thorkelsson, Thordur
Citation:
Acta Paediatr. 2007, 96(3):383-6
Issue Date:
1-Mar-2007
Abstract:
AIM: To evaluate the influence of maternal smoking during pregnancy on factors influencing fetal growth. METHODS: Thirty newborns of smoking mothers were prospectively compared with 60 newborns of non-smoking mothers. Pre-albumin, albumin, triglycerides, glucose, insulin, insulin-like growth factor I, IGF binding protein 3, pH, lactic acid, erythropoietin and hemoglobin concentrations were measured in umbilical cord blood. RESULTS: Infants of smoking mothers had a significantly lower birth weight (3418 +/- 533 vs. 3863 +/- 503 g; p < 0.001), length (50.5 +/- 2,6 vs. 52.3 +/- 1.9 cm; p < 0.001) and head circumference (34.6 +/- 1.8 vs. 35.8 +/- 1.1 cm; p < 0.001) than controls. They also had significantly lower insulin (3.2 (2.0-4.9) vs. 5.8 (4.6-7.1) mU/L; p = 0.008), insulin-like growth factor I (54.4 +/- 32.5 vs. 93.8 +/- 54.5 microg/L; p = 0.001) and IGF binding protein 3 (1664 +/- 432 vs. 1943 +/- 421 microg/L; p = 0.01) concentrations, than controls. Infants of smoking mothers also had significantly higher hemoglobin (167 +/- 14 vs. 157 +/- 13 g/L; p = 0.002) and erythropoietin (42.3 (25.1-72.4) vs. 26.3 (21.9-30.9) U/L; p = 0.03) than controls, but not pH or lactate concentrations. There was no significant difference in pre-albumin, albumin, triglycerides and glucose concentrations. CONCLUSIONS: Smoking during pregnancy causes symmetrical fetal growth impairment, possibly due to decreased oxygen transport to the fetus and decreased concentrations of fetal insulin, insulin-like growth factor I and IGF binding protein 3.
Description:
To access Publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1651-2227.2007.00103.x

Full metadata record

DC FieldValue Language
dc.contributor.authorIngvarsson, Ragnar F-
dc.contributor.authorBjarnason, Anton O-
dc.contributor.authorDagbjartsson, Atli-
dc.contributor.authorHardardottir, Hildur-
dc.contributor.authorHaraldsson, Asgeir-
dc.contributor.authorThorkelsson, Thordur-
dc.date.accessioned2007-04-20T14:44:38Z-
dc.date.available2007-04-20T14:44:38Z-
dc.date.issued2007-03-01-
dc.date.submitted2007-04-20-
dc.identifier.citationActa Paediatr. 2007, 96(3):383-6en
dc.identifier.issn0803-5253-
dc.identifier.pmid17407461-
dc.identifier.doi10.1111/j.1651-2227.2007.00103.x-
dc.identifier.urihttp://hdl.handle.net/2336/11287-
dc.descriptionTo access Publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAIM: To evaluate the influence of maternal smoking during pregnancy on factors influencing fetal growth. METHODS: Thirty newborns of smoking mothers were prospectively compared with 60 newborns of non-smoking mothers. Pre-albumin, albumin, triglycerides, glucose, insulin, insulin-like growth factor I, IGF binding protein 3, pH, lactic acid, erythropoietin and hemoglobin concentrations were measured in umbilical cord blood. RESULTS: Infants of smoking mothers had a significantly lower birth weight (3418 +/- 533 vs. 3863 +/- 503 g; p < 0.001), length (50.5 +/- 2,6 vs. 52.3 +/- 1.9 cm; p < 0.001) and head circumference (34.6 +/- 1.8 vs. 35.8 +/- 1.1 cm; p < 0.001) than controls. They also had significantly lower insulin (3.2 (2.0-4.9) vs. 5.8 (4.6-7.1) mU/L; p = 0.008), insulin-like growth factor I (54.4 +/- 32.5 vs. 93.8 +/- 54.5 microg/L; p = 0.001) and IGF binding protein 3 (1664 +/- 432 vs. 1943 +/- 421 microg/L; p = 0.01) concentrations, than controls. Infants of smoking mothers also had significantly higher hemoglobin (167 +/- 14 vs. 157 +/- 13 g/L; p = 0.002) and erythropoietin (42.3 (25.1-72.4) vs. 26.3 (21.9-30.9) U/L; p = 0.03) than controls, but not pH or lactate concentrations. There was no significant difference in pre-albumin, albumin, triglycerides and glucose concentrations. CONCLUSIONS: Smoking during pregnancy causes symmetrical fetal growth impairment, possibly due to decreased oxygen transport to the fetus and decreased concentrations of fetal insulin, insulin-like growth factor I and IGF binding protein 3.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1111/j.1651-2227.2007.00103.xen
dc.subject.meshFetal Blooden
dc.subject.meshBirth Weighten
dc.subject.meshPregnancyen
dc.subject.meshFetal Developmenten
dc.subject.meshSmokingen
dc.subject.meshInsulin/analysisen
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3en
dc.subject.meshSmokingen
dc.titleThe effects of smoking in pregnancy on factors influencing fetal growthen
dc.typeArticleen
dc.identifier.journalActa paediatrica (Oslo, Norway : 1992)en
dc.format.digYES-
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