Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study

2.50
Hdl Handle:
http://hdl.handle.net/2336/11324
Title:
Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study
Authors:
Hanly, J G; Urowitz, M B; Sanchez-Guerrero, J; Bae, S C; Gordon, C; Wallace, D J; Isenberg, D; Alarcón, G S; Clarke, A; Bernatsky, S; Merrill, J T; Petri, M; Dooley, M A; Gladman, D; Fortin, P R; Steinsson, K; Bruce, I; Manzi, S; Khamashta, M; Zoma, A; Aranow, C; Ginzler, E; Van Vollenhoven, R; Font, J; Sturfelt, G; Nived, O; Ramsey-Goldman, R; Kalunian, K; Douglas, J; Thompson, K; Farewell, V
Citation:
Arthritis Rheum. 2007, 56(1):265-73
Issue Date:
1-Jan-2007
Abstract:
OBJECTIVE: To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. METHODS: The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI). RESULTS: A total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events. CONCLUSION: Twenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1002/art.22305

Full metadata record

DC FieldValue Language
dc.contributor.authorHanly, J G-
dc.contributor.authorUrowitz, M B-
dc.contributor.authorSanchez-Guerrero, J-
dc.contributor.authorBae, S C-
dc.contributor.authorGordon, C-
dc.contributor.authorWallace, D J-
dc.contributor.authorIsenberg, D-
dc.contributor.authorAlarcón, G S-
dc.contributor.authorClarke, A-
dc.contributor.authorBernatsky, S-
dc.contributor.authorMerrill, J T-
dc.contributor.authorPetri, M-
dc.contributor.authorDooley, M A-
dc.contributor.authorGladman, D-
dc.contributor.authorFortin, P R-
dc.contributor.authorSteinsson, K-
dc.contributor.authorBruce, I-
dc.contributor.authorManzi, S-
dc.contributor.authorKhamashta, M-
dc.contributor.authorZoma, A-
dc.contributor.authorAranow, C-
dc.contributor.authorGinzler, E-
dc.contributor.authorVan Vollenhoven, R-
dc.contributor.authorFont, J-
dc.contributor.authorSturfelt, G-
dc.contributor.authorNived, O-
dc.contributor.authorRamsey-Goldman, R-
dc.contributor.authorKalunian, K-
dc.contributor.authorDouglas, J-
dc.contributor.authorThompson, K-
dc.contributor.authorFarewell, V-
dc.date.accessioned2007-04-23T15:33:14Z-
dc.date.available2007-04-23T15:33:14Z-
dc.date.issued2007-01-01-
dc.date.submitted2007-04-23-
dc.identifier.citationArthritis Rheum. 2007, 56(1):265-73en
dc.identifier.issn0004-3591-
dc.identifier.pmid17195230-
dc.identifier.doi10.1002/art.22305-
dc.identifier.urihttp://hdl.handle.net/2336/11324-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. METHODS: The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatology (ACR) SLE classification criteria. All NP events within a predefined enrollment window were identified using the ACR case definitions of 19 NP syndromes. Decision rules were derived to determine the proportion of NP disease attributable to SLE. Clinical significance was determined using the Short Form 36 (SF-36) Health Survey and the SLICC/ACR Damage Index (SDI). RESULTS: A total of 572 patients (88% female) were recruited, with a mean +/- SD age of 35 +/- 14 years. The mean +/- SD disease duration was 5.2 +/- 4.2 months. Within the enrollment window, 158 of 572 patients (28%) had at least 1 NP event. In total, there were 242 NP events that encompassed 15 of 19 NP syndromes. The proportion of NP events attributed to SLE varied from 19% to 38% using alternate attribution models and occurred in 6.1-11.7% of patients. Those with NP events, regardless of attribution, had lower scores on the SF-36 and higher SDI scores compared with patients with no NP events. CONCLUSION: Twenty-eight percent of SLE patients experienced at least 1 NP event around the time of diagnosis of SLE, of which only a minority were attributed to SLE. Regardless of attribution, the occurrence of NP events was associated with reduced quality of life and increased organ damage.en
dc.language.isoenen
dc.publisherWiley-Liss, Inc.en
dc.relation.urlhttp://dx.doi.org/10.1002/art.22305en
dc.subject.meshAdulten
dc.subject.meshCentral Nervous System Diseasesen
dc.subject.meshCohort Studiesen
dc.subject.meshComorbidityen
dc.subject.meshFemaleen
dc.subject.meshHealth Statusen
dc.subject.meshHumansen
dc.subject.meshInternational Cooperationen
dc.subject.meshLupus Erythematosus, Systemicen
dc.subject.meshMaleen
dc.subject.meshNeuropsychological Testsen
dc.subject.meshQuality of Lifeen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshTime Factorsen
dc.subject.meshWorld Healthen
dc.titleNeuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort studyen
dc.typeArticleen
dc.format.digYES-

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