Mucosal Tolerance to KLH Reduces BSA-Induced Arthritis in Rats-An Indication of Bystander Suppression.

2.50
Hdl Handle:
http://hdl.handle.net/2336/12473
Title:
Mucosal Tolerance to KLH Reduces BSA-Induced Arthritis in Rats-An Indication of Bystander Suppression.
Authors:
Freysdottir, Jona; Hardardottir, Ingibjorg; Gizurarson, Sveinbjorn; Vikingsson, Arnor
Citation:
J. Clin. Immunol. 2007, 27(3):284-93
Issue Date:
1-May-2007
Abstract:
Mucosal tolerance has been shown to reduce disease severity in animal models mimicking human autoimmune diseases. The objective of this study was to examine whether mucosal tolerance against keyhole limpet haemocyanin (KLH) could be used to reduce bovine serum albumin (BSA)-induced arthritis in rats and whether anti-inflammatory drugs or passive cigarette smoke affected tolerance induction. Arthritis was induced by immunizing rats with BSA and then injecting BSA into one knee and saline into the other knee for comparison. Prior to BSA immunization, the rats were treated intranasally with KLH or saline and KLH then injected in the knee joints at the time of BSA injection, or the rats were treated with or without anti-inflammatory drugs or subjected to cigarette smoke prior to and during intranasal treatment with BSA. The rats that received intranasal treatment with KLH had a significantly less inflammation in their left knee joint compared to rats that received intranasal saline treatment. Beclamethasone increased the tolerance effect of BSA, whereas passive cigarette smoke abrogated the mucosal tolerance. This data suggests that bystander suppression can be used to treat arthritis and other autoimmune diseases, even when the autoantigen is not known.
Description:
To access Publisher full text version of this article. Please click on the hyperlink in Additional Link
Additional Links:
http://www.springerlink.com/content/5p56pp8q00823423/

Full metadata record

DC FieldValue Language
dc.contributor.authorFreysdottir, Jona-
dc.contributor.authorHardardottir, Ingibjorg-
dc.contributor.authorGizurarson, Sveinbjorn-
dc.contributor.authorVikingsson, Arnor-
dc.date.accessioned2007-07-03T08:42:05Z-
dc.date.available2007-07-03T08:42:05Z-
dc.date.issued2007-05-01-
dc.date.submitted2007-07-03-
dc.identifier.citationJ. Clin. Immunol. 2007, 27(3):284-93en
dc.identifier.issn0271-9142-
dc.identifier.pmid17356923-
dc.identifier.doi10.1007/s10875-007-9081-3-
dc.identifier.urihttp://hdl.handle.net/2336/12473-
dc.descriptionTo access Publisher full text version of this article. Please click on the hyperlink in Additional Linken
dc.description.abstractMucosal tolerance has been shown to reduce disease severity in animal models mimicking human autoimmune diseases. The objective of this study was to examine whether mucosal tolerance against keyhole limpet haemocyanin (KLH) could be used to reduce bovine serum albumin (BSA)-induced arthritis in rats and whether anti-inflammatory drugs or passive cigarette smoke affected tolerance induction. Arthritis was induced by immunizing rats with BSA and then injecting BSA into one knee and saline into the other knee for comparison. Prior to BSA immunization, the rats were treated intranasally with KLH or saline and KLH then injected in the knee joints at the time of BSA injection, or the rats were treated with or without anti-inflammatory drugs or subjected to cigarette smoke prior to and during intranasal treatment with BSA. The rats that received intranasal treatment with KLH had a significantly less inflammation in their left knee joint compared to rats that received intranasal saline treatment. Beclamethasone increased the tolerance effect of BSA, whereas passive cigarette smoke abrogated the mucosal tolerance. This data suggests that bystander suppression can be used to treat arthritis and other autoimmune diseases, even when the autoantigen is not known.en
dc.language.isoenen
dc.publisherKluwer Academic/Plenum Publishersen
dc.relation.urlhttp://www.springerlink.com/content/5p56pp8q00823423/en
dc.subject.meshPubMed - in processen
dc.titleMucosal Tolerance to KLH Reduces BSA-Induced Arthritis in Rats-An Indication of Bystander Suppression.en
dc.typeArticleen
dc.format.digYES-

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