2.50
Hdl Handle:
http://hdl.handle.net/2336/12492
Title:
Young maternal age at delivery is associated with asthma in adult offspring
Authors:
Laerum, Birger N; Svanes, Cecilie; Wentzel-Larsen, Tore; Gulsvik, Amund; Torén, Kjell; Norrman, Eva; Gislason, Thorarinn; Janson, Christer; Omenaas, Ernst
Citation:
Respir Med 2007, 101(7):1431-8
Issue Date:
1-Jul-2007
Abstract:
OBJECTIVE: Some studies have shown an association between lower maternal age at delivery and increased asthma in children and young adults. It is unclear whether this represents an effect of maternal ageing or a protective effect of siblings. In a North-European population based study, we investigated whether mother's age at delivery was associated with risk for asthma and hay fever in adult offspring, taking into account relevant confounders. METHODS: A total of 16,190 subjects (74%) aged 23-54yr answered a postal questionnaire in a follow-up of the European Community Respiratory Health Survey (ECRHS I). RESULTS: The associations of maternal age at delivery with hay fever, respiratory symptoms and diagnosed asthma were analysed using logistic regression, adjusting for household size, dwelling, parental education, centre, gender, adult hay fever, smoking, age and body mass index (BMI). The adjusted odds ratios (95% CI) for wheeze with breathlessness, wheeze without a cold and asthma in the offspring were 0.94 (0.90-0.99), 0.89 (0.86-0.94) and 0.92 (0.88-0.97), respectively, per 5yr increase in maternal age. No heterogeneity between centres was found (p=0.84). The estimates remained similar in sub-sample analyses when adjusting for siblings, maternal smoking (n=3109) and for birth weight (n=1686). Hay fever was more common among those with the youngest and oldest mothers. CONCLUSIONS: In this large North-European multi-centre study, asthma was less common with increasing maternal age. This effect was consistent between centres and persisted with adjustment for several potential confounders, suggesting that the association may possibly be explained by biological changes related to maternal ageing.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WWS-4N7RD47-1/2/1918d4d4e396bbbf0b9e810f8d8052e8

Full metadata record

DC FieldValue Language
dc.contributor.authorLaerum, Birger N-
dc.contributor.authorSvanes, Cecilie-
dc.contributor.authorWentzel-Larsen, Tore-
dc.contributor.authorGulsvik, Amund-
dc.contributor.authorTorén, Kjell-
dc.contributor.authorNorrman, Eva-
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorJanson, Christer-
dc.contributor.authorOmenaas, Ernst-
dc.date.accessioned2007-07-02T09:32:27Z-
dc.date.available2007-07-02T09:32:27Z-
dc.date.issued2007-07-01-
dc.date.submitted2007-07-02-
dc.identifier.citationRespir Med 2007, 101(7):1431-8en
dc.identifier.issn0954-6111-
dc.identifier.pmid17350816-
dc.identifier.doi10.1016/j.rmed.2007.01.020-
dc.identifier.urihttp://hdl.handle.net/2336/12492-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: Some studies have shown an association between lower maternal age at delivery and increased asthma in children and young adults. It is unclear whether this represents an effect of maternal ageing or a protective effect of siblings. In a North-European population based study, we investigated whether mother's age at delivery was associated with risk for asthma and hay fever in adult offspring, taking into account relevant confounders. METHODS: A total of 16,190 subjects (74%) aged 23-54yr answered a postal questionnaire in a follow-up of the European Community Respiratory Health Survey (ECRHS I). RESULTS: The associations of maternal age at delivery with hay fever, respiratory symptoms and diagnosed asthma were analysed using logistic regression, adjusting for household size, dwelling, parental education, centre, gender, adult hay fever, smoking, age and body mass index (BMI). The adjusted odds ratios (95% CI) for wheeze with breathlessness, wheeze without a cold and asthma in the offspring were 0.94 (0.90-0.99), 0.89 (0.86-0.94) and 0.92 (0.88-0.97), respectively, per 5yr increase in maternal age. No heterogeneity between centres was found (p=0.84). The estimates remained similar in sub-sample analyses when adjusting for siblings, maternal smoking (n=3109) and for birth weight (n=1686). Hay fever was more common among those with the youngest and oldest mothers. CONCLUSIONS: In this large North-European multi-centre study, asthma was less common with increasing maternal age. This effect was consistent between centres and persisted with adjustment for several potential confounders, suggesting that the association may possibly be explained by biological changes related to maternal ageing.en
dc.language.isoenen
dc.publisherW.B. Saundersen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WWS-4N7RD47-1/2/1918d4d4e396bbbf0b9e810f8d8052e8en
dc.subject.meshPubMed - in processen
dc.titleYoung maternal age at delivery is associated with asthma in adult offspringen
dc.typeArticleen
dc.identifier.journalRespiratory Medicineen
dc.format.digYES-

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