2.50
Hdl Handle:
http://hdl.handle.net/2336/12494
Title:
A common variant on chromosome 9p21 affects the risk of myocardial infarction
Authors:
Helgadottir, Anna; Thorleifsson, Gudmar; Manolescu, Andrei; Gretarsdottir, Solveig; Blondal, Thorarinn; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Sigurdsson, Asgeir; Baker, Adam; Palsson, Arnar; Masson, Gisli; Gudbjartsson, Daniel F; Magnusson, Kristinn P; Andersen, Karl; Levey, Allan I; Backman, Valgerdur M; Matthiasdottir, Sigurborg; Jonsdottir, Thorbjorg; Palsson, Stefan; Einarsdottir, Helga; Gunnarsdottir, Steinunn; Gylfason, Arnaldur; Vaccarino, Viola; Hooper, W Craig; Reilly, Muredach P; Granger, Christopher B; Austin, Harland; Rader, Daniel J; Shah, Svati H; Quyyumi, Arshed A; Gulcher, Jeffrey R; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
Citation:
Science 2007, 316(5830):1491-3
Issue Date:
8-Jun-2007
Abstract:
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencemag.org/cgi/content/full/316/5830/1491

Full metadata record

DC FieldValue Language
dc.contributor.authorHelgadottir, Anna-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorJonasdottir, Aslaug-
dc.contributor.authorJonasdottir, Adalbjorg-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorBaker, Adam-
dc.contributor.authorPalsson, Arnar-
dc.contributor.authorMasson, Gisli-
dc.contributor.authorGudbjartsson, Daniel F-
dc.contributor.authorMagnusson, Kristinn P-
dc.contributor.authorAndersen, Karl-
dc.contributor.authorLevey, Allan I-
dc.contributor.authorBackman, Valgerdur M-
dc.contributor.authorMatthiasdottir, Sigurborg-
dc.contributor.authorJonsdottir, Thorbjorg-
dc.contributor.authorPalsson, Stefan-
dc.contributor.authorEinarsdottir, Helga-
dc.contributor.authorGunnarsdottir, Steinunn-
dc.contributor.authorGylfason, Arnaldur-
dc.contributor.authorVaccarino, Viola-
dc.contributor.authorHooper, W Craig-
dc.contributor.authorReilly, Muredach P-
dc.contributor.authorGranger, Christopher B-
dc.contributor.authorAustin, Harland-
dc.contributor.authorRader, Daniel J-
dc.contributor.authorShah, Svati H-
dc.contributor.authorQuyyumi, Arshed A-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorThorgeirsson, Gudmundur-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2007-07-02T10:00:17Z-
dc.date.available2007-07-02T10:00:17Z-
dc.date.issued2007-06-08-
dc.date.submitted2007-07-02-
dc.identifier.citationScience 2007, 316(5830):1491-3en
dc.identifier.issn1095-9203-
dc.identifier.pmid17478679-
dc.identifier.doi10.1126/science.1142842-
dc.identifier.urihttp://hdl.handle.net/2336/12494-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.en
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.relation.urlhttp://www.sciencemag.org/cgi/content/full/316/5830/1491en
dc.subject.meshVariation (Genetics)en
dc.subject.meshRisk Factorsen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshMyocardial Infarctionen
dc.subject.meshMiddle Ageden
dc.subject.meshMaleen
dc.subject.meshLinkage Disequilibriumen
dc.subject.meshHumansen
dc.subject.meshHomozygoteen
dc.subject.meshHaplotypesen
dc.subject.meshGenotypeen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenes, p16en
dc.subject.meshCoronary Arteriosclerosisen
dc.subject.meshChromosomes, Human, Pair 9en
dc.subject.meshChromosome Mappingen
dc.subject.meshAge of Onseten
dc.titleA common variant on chromosome 9p21 affects the risk of myocardial infarctionen
dc.typeArticleen
dc.format.digYES-

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