2.50
Hdl Handle:
http://hdl.handle.net/2336/12498
Title:
Mouse models of psoriasis
Authors:
Gudjonsson, Johann E; Johnston, Andrew; Dyson, Melissa; Valdimarsson, Helgi; Elder, James T
Citation:
J. Invest. Dermatol. 2007, 127(6):1292-308
Issue Date:
1-Jun-2007
Abstract:
Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of autoimmune nature that can be triggered or worsened by streptococcal throat infections. In addition to conventional chronic inflammatory changes, psoriasis is characterized by complex and striking alterations in epidermal growth and differentiation. Psoriasis is generally not observed in animals other than man, and this lack of a suitable animal model has greatly hindered research into the pathogenesis of psoriasis. Multiple transgenic, knockout, and reconstituted models of psoriasis have been developed over the past two decades. Despite their limitations, these models have demonstrated that keratinocyte hyperplasia, vascular hyperplasia, and cell-mediated immunity in the skin are closely interrelated. Xenograft models, in which involved and uninvolved psoriatic skin are transplanted onto immunodeficient mice, are the only models that come close to incorporating the complete genetic, immunologic, and phenotypic changes of the disease. They have shown conclusively that psoriasis is a T-cell-mediated disease, and have been used to elucidate novel pathogenic pathways. In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.nature.com/jid/journal/v127/n6/full/5700807a.html

Full metadata record

DC FieldValue Language
dc.contributor.authorGudjonsson, Johann E-
dc.contributor.authorJohnston, Andrew-
dc.contributor.authorDyson, Melissa-
dc.contributor.authorValdimarsson, Helgi-
dc.contributor.authorElder, James T-
dc.date.accessioned2007-07-02T11:00:44Z-
dc.date.available2007-07-02T11:00:44Z-
dc.date.issued2007-06-01-
dc.date.submitted2007-07-02-
dc.identifier.citationJ. Invest. Dermatol. 2007, 127(6):1292-308en
dc.identifier.issn1523-1747-
dc.identifier.pmid17429444-
dc.identifier.doi10.1038/sj.jid.5700807-
dc.identifier.urihttp://hdl.handle.net/2336/12498-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPsoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of autoimmune nature that can be triggered or worsened by streptococcal throat infections. In addition to conventional chronic inflammatory changes, psoriasis is characterized by complex and striking alterations in epidermal growth and differentiation. Psoriasis is generally not observed in animals other than man, and this lack of a suitable animal model has greatly hindered research into the pathogenesis of psoriasis. Multiple transgenic, knockout, and reconstituted models of psoriasis have been developed over the past two decades. Despite their limitations, these models have demonstrated that keratinocyte hyperplasia, vascular hyperplasia, and cell-mediated immunity in the skin are closely interrelated. Xenograft models, in which involved and uninvolved psoriatic skin are transplanted onto immunodeficient mice, are the only models that come close to incorporating the complete genetic, immunologic, and phenotypic changes of the disease. They have shown conclusively that psoriasis is a T-cell-mediated disease, and have been used to elucidate novel pathogenic pathways. In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/jid/journal/v127/n6/full/5700807a.htmlen
dc.subject.meshAnimalsen
dc.subject.meshDisease Models, Animalen
dc.subject.meshMiceen
dc.subject.meshMice, Knockouten
dc.subject.meshMice, Mutant Strainsen
dc.subject.meshPsoriasisen
dc.titleMouse models of psoriasisen
dc.typeArticleen
dc.format.digYES-

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