2.50
Hdl Handle:
http://hdl.handle.net/2336/13045
Title:
Monoclonal gammopathy: natural history studied with a retrospective approach
Authors:
Steingrimsdottir, Hlif; Haraldsdottir, Vilhelmina; Olafsson, Isleifur; Gudnason, Vilmundur; Ogmundsdottir, Helga M
Citation:
Haematologica 2007, 92(8):1131-4
Issue Date:
1-Aug-2007
Abstract:
The aim of this study was to examine the natural history of monoclonal gammopathy using a retrospective approach and a long observation period. Protein electrophoresis (PE) and immunofixation (IF) was performed on frozen prediagnosis serum samples from 65 multiple myeloma (MM) and 10 Waldenström's macroglobulinemia (WM) cases. Paraprotein was found in 28% and 46% of the samples from cases using PE and IF respectively. The type of paraprotein was IgA in 33.4% of cases, IgG in 57%, and IgM in 8.5%. Excluding light chain or non-secretory disease, 72 % of MM cases had a prodromal MGUS phase within 10 years of diagnosis MM and WM were preceded by MGUS in at least half of the cases, confirming the premalignant nature of this condition.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://www.haematologica.org/cgi/content/abstract/92/8/1131

Full metadata record

DC FieldValue Language
dc.contributor.authorSteingrimsdottir, Hlif-
dc.contributor.authorHaraldsdottir, Vilhelmina-
dc.contributor.authorOlafsson, Isleifur-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorOgmundsdottir, Helga M-
dc.date.accessioned2007-07-31T12:48:17Z-
dc.date.available2007-07-31T12:48:17Z-
dc.date.issued2007-08-01-
dc.date.submitted2007-07-31-
dc.identifier.citationHaematologica 2007, 92(8):1131-4en
dc.identifier.issn1592-8721-
dc.identifier.pmid17650445-
dc.identifier.urihttp://hdl.handle.net/2336/13045-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractThe aim of this study was to examine the natural history of monoclonal gammopathy using a retrospective approach and a long observation period. Protein electrophoresis (PE) and immunofixation (IF) was performed on frozen prediagnosis serum samples from 65 multiple myeloma (MM) and 10 Waldenström's macroglobulinemia (WM) cases. Paraprotein was found in 28% and 46% of the samples from cases using PE and IF respectively. The type of paraprotein was IgA in 33.4% of cases, IgG in 57%, and IgM in 8.5%. Excluding light chain or non-secretory disease, 72 % of MM cases had a prodromal MGUS phase within 10 years of diagnosis MM and WM were preceded by MGUS in at least half of the cases, confirming the premalignant nature of this condition.en
dc.language.isoenen
dc.publisherFerrata Storti Foundationen
dc.relation.urlhttp://www.haematologica.org/cgi/content/abstract/92/8/1131en
dc.subject.classificationMultiple Myelomaen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshDisease Progressionen
dc.subject.meshWaldenstrom Macroglobulinemiaen
dc.subject.meshPrecancerous Conditionsen
dc.titleMonoclonal gammopathy: natural history studied with a retrospective approachen
dc.typeArticleen
dc.contributor.departmentLandspitali University Hospital, Department of Clinical Hematology, Reykjavik, Iceland.en
dc.identifier.journalHaematologicaen
dc.format.digYES-

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