2.50
Hdl Handle:
http://hdl.handle.net/2336/13048
Title:
Variants conferring risk of atrial fibrillation on chromosome 4q25.
Authors:
Gudbjartsson, Daniel F; Arnar, David O; Helgadottir, Anna; Gretarsdottir, Solveig; Holm, Hilma; Sigurdsson, Asgeir; Jonasdottir, Adalbjorg; Baker, Adam; Thorleifsson, Gudmar; Kristjansson, Kristleifur; Palsson, Arnar; Blondal, Thorarinn; Sulem, Patrick; Backman, Valgerdur M; Hardarson, Gudmundur A; Palsdottir, Ebba; Helgason, Agnar; Sigurjonsdottir, Runa; Sverrisson, Jon T; Kostulas, Konstantinos; Ng, Maggie C Y; Baum, Larry; So, Wing Yee; Wong, Ka Sing; Chan, Juliana C N; Furie, Karen L; Greenberg, Steven M; Sale, Michelle; Kelly, Peter; MacRae, Calum A; Smith, Eric E; Rosand, Jonathan; Hillert, Jan; Ma, Ronald C W; Ellinor, Patrick T; Thorgeirsson, Gudmundur; Gulcher, Jeffrey R; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nature 2007, 448(7151):353-7
Issue Date:
19-Jul-2007
Abstract:
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. Recent studies have provided evidence of a genetic contribution to AF. Mutations in potassium-channel genes have been associated with familial AF but account for only a small fraction of all cases of AF. We have performed a genome-wide association scan, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and find a strong association between two sequence variants on chromosome 4q25 and AF. Here we show that about 35% of individuals of European descent have at least one of the variants and that the risk of AF increases by 1.72 and 1.39 per copy. The association with the stronger variant is replicated in the Chinese population, where it is carried by 75% of individuals and the risk of AF is increased by 1.42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://www.nature.com/nature/journal/v448/n7151/abs/nature06007.html

Full metadata record

DC FieldValue Language
dc.contributor.authorGudbjartsson, Daniel F-
dc.contributor.authorArnar, David O-
dc.contributor.authorHelgadottir, Anna-
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorHolm, Hilma-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorJonasdottir, Adalbjorg-
dc.contributor.authorBaker, Adam-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorPalsson, Arnar-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorBackman, Valgerdur M-
dc.contributor.authorHardarson, Gudmundur A-
dc.contributor.authorPalsdottir, Ebba-
dc.contributor.authorHelgason, Agnar-
dc.contributor.authorSigurjonsdottir, Runa-
dc.contributor.authorSverrisson, Jon T-
dc.contributor.authorKostulas, Konstantinos-
dc.contributor.authorNg, Maggie C Y-
dc.contributor.authorBaum, Larry-
dc.contributor.authorSo, Wing Yee-
dc.contributor.authorWong, Ka Sing-
dc.contributor.authorChan, Juliana C N-
dc.contributor.authorFurie, Karen L-
dc.contributor.authorGreenberg, Steven M-
dc.contributor.authorSale, Michelle-
dc.contributor.authorKelly, Peter-
dc.contributor.authorMacRae, Calum A-
dc.contributor.authorSmith, Eric E-
dc.contributor.authorRosand, Jonathan-
dc.contributor.authorHillert, Jan-
dc.contributor.authorMa, Ronald C W-
dc.contributor.authorEllinor, Patrick T-
dc.contributor.authorThorgeirsson, Gudmundur-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorKong, Augustine-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2007-07-31T13:32:31Z-
dc.date.available2007-07-31T13:32:31Z-
dc.date.issued2007-07-19-
dc.date.submitted2007-07-31-
dc.identifier.citationNature 2007, 448(7151):353-7en
dc.identifier.issn1476-4687-
dc.identifier.pmid17603472-
dc.identifier.doi10.1038/nature06007-
dc.identifier.urihttp://hdl.handle.net/2336/13048-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. Recent studies have provided evidence of a genetic contribution to AF. Mutations in potassium-channel genes have been associated with familial AF but account for only a small fraction of all cases of AF. We have performed a genome-wide association scan, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and find a strong association between two sequence variants on chromosome 4q25 and AF. Here we show that about 35% of individuals of European descent have at least one of the variants and that the risk of AF increases by 1.72 and 1.39 per copy. The association with the stronger variant is replicated in the Chinese population, where it is carried by 75% of individuals and the risk of AF is increased by 1.42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/nature/journal/v448/n7151/abs/nature06007.htmlen
dc.subject.meshPubMed - in processen
dc.titleVariants conferring risk of atrial fibrillation on chromosome 4q25.en
dc.typeArticleen
dc.format.digYES-

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