2.50
Hdl Handle:
http://hdl.handle.net/2336/13083
Title:
Sulphasalazine inhibits human antigen-specific immune responses in vivo
Authors:
Trollmo, Christina; Gudmundsson, Sveinn; Feltelius, Nils; Rogberg, Siv; Smedegård, Göran; Klareskog, Lars
Citation:
Ann. Rheum. Dis. 2007, 66(4):481-5
Issue Date:
1-Apr-2007
Abstract:
OBJECTIVE: To study the effects of the antirheumatic drug sulphasalazine (SASP) on the immune system by analysing systemic and gut-associated immune responses. METHODS: A total of 23 healthy volunteers were treated with either SASP or placebo for 5 weeks in a double-blind fashion and immunised 2 weeks after the initiation of treatment. Specific immune responses were triggered by subcutaneous immunisation with tetanus toxoid and by peroral immunisation with inactivated influenza vaccine. The effects of treatment on specific immunity to tetanus and influenza were evaluated by enzyme-linked immunospot assay quantifying the number of circulating specific and total antibody-producing cells (spot-forming cells (SFC)) at 6, 8 and 10 days after immunisation. RESULTS: An immunosuppressive effect of SASP on systemic immune response was observed with a decrease in the total number of IgG-SFC, IgG anti-tetanus SFC and IgG anti-tetanus antibody levels in serum. SASP also exerted an immunosuppressive effect on the mucosa-associated immune system as seen from its down-regulating effect on the total number of circulating IgA SFC. CONCLUSIONS: These data show firstly that SASP exerts an immunosuppressive effect on defined immune responses to immunisation in vivo, and secondly that both mucosa-associated and systemic immunity are affected by SASP treatment.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ard.bmj.com/cgi/content/full/66/4/481?eaf

Full metadata record

DC FieldValue Language
dc.contributor.authorTrollmo, Christina-
dc.contributor.authorGudmundsson, Sveinn-
dc.contributor.authorFeltelius, Nils-
dc.contributor.authorRogberg, Siv-
dc.contributor.authorSmedegård, Göran-
dc.contributor.authorKlareskog, Lars-
dc.date.accessioned2007-08-02T09:16:07Z-
dc.date.available2007-08-02T09:16:07Z-
dc.date.issued2007-04-01-
dc.date.submitted2007-08-02-
dc.identifier.citationAnn. Rheum. Dis. 2007, 66(4):481-5en
dc.identifier.issn0003-4967-
dc.identifier.pmid16984937-
dc.identifier.doi10.1136/ard.2006.059881-
dc.identifier.otherBAB12-
dc.identifier.urihttp://hdl.handle.net/2336/13083-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To study the effects of the antirheumatic drug sulphasalazine (SASP) on the immune system by analysing systemic and gut-associated immune responses. METHODS: A total of 23 healthy volunteers were treated with either SASP or placebo for 5 weeks in a double-blind fashion and immunised 2 weeks after the initiation of treatment. Specific immune responses were triggered by subcutaneous immunisation with tetanus toxoid and by peroral immunisation with inactivated influenza vaccine. The effects of treatment on specific immunity to tetanus and influenza were evaluated by enzyme-linked immunospot assay quantifying the number of circulating specific and total antibody-producing cells (spot-forming cells (SFC)) at 6, 8 and 10 days after immunisation. RESULTS: An immunosuppressive effect of SASP on systemic immune response was observed with a decrease in the total number of IgG-SFC, IgG anti-tetanus SFC and IgG anti-tetanus antibody levels in serum. SASP also exerted an immunosuppressive effect on the mucosa-associated immune system as seen from its down-regulating effect on the total number of circulating IgA SFC. CONCLUSIONS: These data show firstly that SASP exerts an immunosuppressive effect on defined immune responses to immunisation in vivo, and secondly that both mucosa-associated and systemic immunity are affected by SASP treatment.en
dc.language.isoenen
dc.publisherBmj Publishing Groupen
dc.relation.urlhttp://ard.bmj.com/cgi/content/full/66/4/481?eafen
dc.subject.meshAntibodies, Bacterialen
dc.subject.meshAntibodies, Viralen
dc.subject.meshAntibody-Producing Cellsen
dc.subject.meshDouble-Blind Methoden
dc.subject.meshEnzyme-Linked Immunosorbent Assayen
dc.subject.meshImmunity, Mucosalen
dc.subject.meshImmunoglobulin Aen
dc.subject.meshImmunoglobulin Gen
dc.subject.meshInfluenza Vaccinesen
dc.subject.meshSulfasalazineen
dc.titleSulphasalazine inhibits human antigen-specific immune responses in vivoen
dc.typeArticleen
dc.format.digYES-
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