The improved survival of experimental animals fed with fish oil is suppressed by a leukotriene inhibitor

2.50
Hdl Handle:
http://hdl.handle.net/2336/13594
Title:
The improved survival of experimental animals fed with fish oil is suppressed by a leukotriene inhibitor
Authors:
Thors, V S; Erlendsdottir, H; Olafsson, O; Gunnarsson, E; Haraldsson, A
Citation:
Scand. J. Immunol. 2004, 60(4):351-5
Issue Date:
1-Oct-2004
Abstract:
Fish oil is believed to alter the immune response and improve survival after infections in experimental animals. This effect may be due to altered production of the leukotrienes (LT). We, therefore, performed a study in order to evaluate whether the effect of fish oil on the immune response of experimental animals is mediated through altered production of the LT. Female NMRI mice in four groups were fed with fish oil, fish oil with 5-lipoxygenase (5-LO) inhibitor (Zileuton, Abbott Laboratories, Chicago, IL, USA), corn oil or corn oil with 5-LO inhibitor. After 6 weeks, the mice were infected with Klebsiella pneumoniae and the survival was monitored. The experiment was performed twice. Analysis was performed mainly on data pooled from both experiments. The survival of the groups fed with fish oil was increased, compared to that of all the other groups and when compared to the groups fed with fish oil with 5-LO inhibitor (log-rank test) the difference was significant (P = 0.007). It has been postulated that the effect of fish oil on the immune system is mediated through altered production of LT. In our study, blocking of the production of the LT eliminated the beneficial effects of fish oil. Our results are in concord with the hypothesis that the effect of fish oil is, at least partly, mediated through altered production of LT.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.blackwell-synergy.com/doi/abs/10.1111/j.0300-9475.2004.01488.x

Full metadata record

DC FieldValue Language
dc.contributor.authorThors, V S-
dc.contributor.authorErlendsdottir, H-
dc.contributor.authorOlafsson, O-
dc.contributor.authorGunnarsson, E-
dc.contributor.authorHaraldsson, A-
dc.date.accessioned2007-09-12T11:37:26Z-
dc.date.available2007-09-12T11:37:26Z-
dc.date.issued2004-10-01-
dc.date.submitted2007-09-12-
dc.identifier.citationScand. J. Immunol. 2004, 60(4):351-5en
dc.identifier.issn0300-9475-
dc.identifier.pmid15379859-
dc.identifier.doi10.1111/j.0300-9475.2004.01488.x-
dc.identifier.urihttp://hdl.handle.net/2336/13594-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractFish oil is believed to alter the immune response and improve survival after infections in experimental animals. This effect may be due to altered production of the leukotrienes (LT). We, therefore, performed a study in order to evaluate whether the effect of fish oil on the immune response of experimental animals is mediated through altered production of the LT. Female NMRI mice in four groups were fed with fish oil, fish oil with 5-lipoxygenase (5-LO) inhibitor (Zileuton, Abbott Laboratories, Chicago, IL, USA), corn oil or corn oil with 5-LO inhibitor. After 6 weeks, the mice were infected with Klebsiella pneumoniae and the survival was monitored. The experiment was performed twice. Analysis was performed mainly on data pooled from both experiments. The survival of the groups fed with fish oil was increased, compared to that of all the other groups and when compared to the groups fed with fish oil with 5-LO inhibitor (log-rank test) the difference was significant (P = 0.007). It has been postulated that the effect of fish oil on the immune system is mediated through altered production of LT. In our study, blocking of the production of the LT eliminated the beneficial effects of fish oil. Our results are in concord with the hypothesis that the effect of fish oil is, at least partly, mediated through altered production of LT.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1111/j.0300-9475.2004.01488.xen
dc.subject.meshDietary Fats, Unsaturateden
dc.subject.meshFish Oilsen
dc.subject.meshHydroxyureaen
dc.subject.meshKlebsiella Infectionsen
dc.subject.meshKlebsiella pneumoniaeen
dc.subject.meshLeukotriene Antagonistsen
dc.subject.meshLeukotrienesen
dc.subject.meshLipoxygenase Inhibitorsen
dc.titleThe improved survival of experimental animals fed with fish oil is suppressed by a leukotriene inhibitoren
dc.typeArticleen
dc.identifier.journalScandinavian journal of immunologyen
dc.format.digYES-

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