2.50
Hdl Handle:
http://hdl.handle.net/2336/13599
Title:
A [17F]-fluoromethane PET/TMS study of effective connectivity
Authors:
Ferrarelli, Fabio; Haraldsson, H Magnus; Barnhart, Todd E; Roberts, Andy D; Oakes, Terrence R; Massimini, Marcello; Stone, Charles K; Kalin, Ned H; Tononi, Giulio
Citation:
Brain Res. Bull. 2004, 64(2):103-13
Issue Date:
30-Aug-2004
Abstract:
We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6SYT-4CXKPYM-1/2/35c3ec7db8ec8051936f96372a08e962

Full metadata record

DC FieldValue Language
dc.contributor.authorFerrarelli, Fabio-
dc.contributor.authorHaraldsson, H Magnus-
dc.contributor.authorBarnhart, Todd E-
dc.contributor.authorRoberts, Andy D-
dc.contributor.authorOakes, Terrence R-
dc.contributor.authorMassimini, Marcello-
dc.contributor.authorStone, Charles K-
dc.contributor.authorKalin, Ned H-
dc.contributor.authorTononi, Giulio-
dc.date.accessioned2007-09-12T14:49:42Z-
dc.date.available2007-09-12T14:49:42Z-
dc.date.issued2004-08-30-
dc.date.submitted2007-09-12-
dc.identifier.citationBrain Res. Bull. 2004, 64(2):103-13en
dc.identifier.issn0361-9230-
dc.identifier.pmid15342097-
dc.identifier.doi10.1016/j.brainresbull.2004.04.020-
dc.identifier.otherPSY12-
dc.identifier.urihttp://hdl.handle.net/2336/13599-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [17F]-[CH3F] ([17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [15O]-H2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits.en
dc.language.isoenen
dc.publisherElsevier Scienceen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6SYT-4CXKPYM-1/2/35c3ec7db8ec8051936f96372a08e962en
dc.subject.meshBrain Mappingen
dc.subject.meshCerebral Cortexen
dc.subject.meshElectric Stimulationen
dc.subject.meshHydrocarbons, Fluorinateden
dc.subject.meshImage Processing, Computer-Assisteden
dc.subject.meshMagneticsen
dc.subject.meshNeural Networks (Computer)en
dc.subject.meshPositron-Emission Tomographyen
dc.titleA [17F]-fluoromethane PET/TMS study of effective connectivityen
dc.typeArticleen
dc.identifier.journalBrain research bulletinen
dc.format.digYES-

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