Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

2.50
Hdl Handle:
http://hdl.handle.net/2336/14444
Title:
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
Authors:
Gudmundsson, Julius; Sulem, Patrick; Steinthorsdottir, Valgerdur; Bergthorsson, Jon T; Thorleifsson, Gudmar; Manolescu, Andrei; Rafnar, Thorunn; Gudbjartsson, Daniel; Agnarsson, Bjarni A; Baker, Adam; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Jakobsdottir, Margret; Blondal, Thorarinn; Stacey, Simon N; Helgason, Agnar; Gunnarsdottir, Steinunn; Olafsdottir, Adalheidur; Kristinsson, Kari T; Birgisdottir, Birgitta; Ghosh, Shyamali; Thorlacius, Steinunn; Magnusdottir, Dana; Stefansdottir, Gerdur; Kristjansson, Kristleifur; Bagger, Yu; Wilensky, Robert L; Reilly, Muredach P; Morris, Andrew D; Kimber, Charlotte H; Adeyemo, Adebowale; Chen, Yuanxiu; Zhou, Jie; So, Wing-Yee; Tong, Peter C Y; Ng, Maggie C Y; Hansen, Torben; Andersen, Gitte; Borch-Johnsen, Knut; Jorgensen, Torben; Tres, Alejandro; Fuertes, Fernando; Ruiz-Echarri, Manuel; Asin, Laura; Saez, Berta; van Boven, Erica; Klaver, Siem; Swinkels, Dorine W; Aben, Katja K; Graif, Theresa; Cashy, John; Suarez, Brian K; van Vierssen Trip, Onco; Frigge, Michael L; Ober, Carole; Hofker, Marten H; Wijmenga, Cisca; Christiansen, Claus; Rader, Daniel J; Palmer, Colin N A; Rotimi, Charles; Chan, Juliana C N; Pedersen, Oluf; Sigurdsson, Gunnar; Benediktsson, Rafn; Jonsson, Eirikur; Einarsson, Gudmundur V; Mayordomo, Jose I; Catalona, William J; Kiemeney, Lambertus A; Barkardottir, Rosa B; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
Citation:
Nat. Genet. 2007, 39(8):977-83
Issue Date:
1-Aug-2007
Abstract:
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng2062

Full metadata record

DC FieldValue Language
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorSteinthorsdottir, Valgerdur-
dc.contributor.authorBergthorsson, Jon T-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorAgnarsson, Bjarni A-
dc.contributor.authorBaker, Adam-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorBenediktsdottir, Kristrun R-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorStacey, Simon N-
dc.contributor.authorHelgason, Agnar-
dc.contributor.authorGunnarsdottir, Steinunn-
dc.contributor.authorOlafsdottir, Adalheidur-
dc.contributor.authorKristinsson, Kari T-
dc.contributor.authorBirgisdottir, Birgitta-
dc.contributor.authorGhosh, Shyamali-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorMagnusdottir, Dana-
dc.contributor.authorStefansdottir, Gerdur-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorBagger, Yu-
dc.contributor.authorWilensky, Robert L-
dc.contributor.authorReilly, Muredach P-
dc.contributor.authorMorris, Andrew D-
dc.contributor.authorKimber, Charlotte H-
dc.contributor.authorAdeyemo, Adebowale-
dc.contributor.authorChen, Yuanxiu-
dc.contributor.authorZhou, Jie-
dc.contributor.authorSo, Wing-Yee-
dc.contributor.authorTong, Peter C Y-
dc.contributor.authorNg, Maggie C Y-
dc.contributor.authorHansen, Torben-
dc.contributor.authorAndersen, Gitte-
dc.contributor.authorBorch-Johnsen, Knut-
dc.contributor.authorJorgensen, Torben-
dc.contributor.authorTres, Alejandro-
dc.contributor.authorFuertes, Fernando-
dc.contributor.authorRuiz-Echarri, Manuel-
dc.contributor.authorAsin, Laura-
dc.contributor.authorSaez, Berta-
dc.contributor.authorvan Boven, Erica-
dc.contributor.authorKlaver, Siem-
dc.contributor.authorSwinkels, Dorine W-
dc.contributor.authorAben, Katja K-
dc.contributor.authorGraif, Theresa-
dc.contributor.authorCashy, John-
dc.contributor.authorSuarez, Brian K-
dc.contributor.authorvan Vierssen Trip, Onco-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorOber, Carole-
dc.contributor.authorHofker, Marten H-
dc.contributor.authorWijmenga, Cisca-
dc.contributor.authorChristiansen, Claus-
dc.contributor.authorRader, Daniel J-
dc.contributor.authorPalmer, Colin N A-
dc.contributor.authorRotimi, Charles-
dc.contributor.authorChan, Juliana C N-
dc.contributor.authorPedersen, Oluf-
dc.contributor.authorSigurdsson, Gunnar-
dc.contributor.authorBenediktsson, Rafn-
dc.contributor.authorJonsson, Eirikur-
dc.contributor.authorEinarsson, Gudmundur V-
dc.contributor.authorMayordomo, Jose I-
dc.contributor.authorCatalona, William J-
dc.contributor.authorKiemeney, Lambertus A-
dc.contributor.authorBarkardottir, Rosa B-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2007-11-05T08:37:30Z-
dc.date.available2007-11-05T08:37:30Z-
dc.date.issued2007-08-01-
dc.date.submitted2007-11-05-
dc.identifier.citationNat. Genet. 2007, 39(8):977-83en
dc.identifier.issn1061-4036-
dc.identifier.pmid17603485-
dc.identifier.doi10.1038/ng2062-
dc.identifier.urihttp://hdl.handle.net/2336/14444-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng2062en
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromosomes, Human, Pair 17en
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHaplotypesen
dc.subject.meshHepatocyte Nuclear Factor 1-betaen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshProstatic Neoplasmsen
dc.titleTwo variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesen
dc.typeArticleen
dc.identifier.journalNature geneticsen
dc.format.digYES-

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