2.50
Hdl Handle:
http://hdl.handle.net/2336/14466
Title:
Psoriasis: a complex clinical and genetic disorder
Authors:
Valdimarsson, Helgi; Karason, Ari; Gudjonsson, Johann E
Citation:
Curr Rheumatol Rep 2004, 6(4):314-6
Issue Date:
1-Aug-2004
Abstract:
Psoriasis is associated with arthritis in approximately 10% of patients. The skin disease and arthritis have a strong but complex genetic component. Several susceptibility loci have been reported including one major locus that maps very close to the human leukocyte antigen-C gene on chromosome 6p. No causative gene has so far been conclusively identified. A recent genetic analysis that only included patients with psoriatic arthritis revealed a highly significant susceptibility locus on chromosome 16q approximately 20 cM from the NOD2 gene that has been associated with Crohn's disease. This locus was barely detectable when the entire cohort of psoriasis patients was analyzed as a homogeneous entity. A further clinical stratification of psoriasis patients has revealed novel strongly suggestive loci and also increased the logarithm of the odds scores of some previously reported loci. It is concluded that a careful documentation of clinical features and phenotypic stratification may help to analyze complex genetic disorders.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.springerlink.com/content/t8733754r4047512

Full metadata record

DC FieldValue Language
dc.contributor.authorValdimarsson, Helgi-
dc.contributor.authorKarason, Ari-
dc.contributor.authorGudjonsson, Johann E-
dc.date.accessioned2007-11-05T13:19:45Z-
dc.date.available2007-11-05T13:19:45Z-
dc.date.issued2004-08-01-
dc.date.submitted2007-11-05-
dc.identifier.citationCurr Rheumatol Rep 2004, 6(4):314-6en
dc.identifier.issn1523-3774-
dc.identifier.pmid15251084-
dc.identifier.doi10.1007/s11926-004-0044-x-
dc.identifier.urihttp://hdl.handle.net/2336/14466-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPsoriasis is associated with arthritis in approximately 10% of patients. The skin disease and arthritis have a strong but complex genetic component. Several susceptibility loci have been reported including one major locus that maps very close to the human leukocyte antigen-C gene on chromosome 6p. No causative gene has so far been conclusively identified. A recent genetic analysis that only included patients with psoriatic arthritis revealed a highly significant susceptibility locus on chromosome 16q approximately 20 cM from the NOD2 gene that has been associated with Crohn's disease. This locus was barely detectable when the entire cohort of psoriasis patients was analyzed as a homogeneous entity. A further clinical stratification of psoriasis patients has revealed novel strongly suggestive loci and also increased the logarithm of the odds scores of some previously reported loci. It is concluded that a careful documentation of clinical features and phenotypic stratification may help to analyze complex genetic disorders.en
dc.language.isoenen
dc.publisherCurrent Scienceen
dc.relation.urlhttp://www.springerlink.com/content/t8733754r4047512-
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshLinkage (Genetics)en
dc.subject.meshLod Scoreen
dc.subject.meshPsoriasisen
dc.titlePsoriasis: a complex clinical and genetic disorderen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Landspitali University Hospital, Eiriksgata, 101 Reykjavik, Iceland. helgiv@landspitali.isen
dc.identifier.journalCurrent rheumatology reportsen
dc.format.digYES-

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