2.50
Hdl Handle:
http://hdl.handle.net/2336/14470
Title:
The contraceptive vaginal ring (NuvaRing) and hemostasis: a comparative study
Authors:
Magnusdottir, E M; Bjarnadottir, R I; Onundarson, P T; Gudmundsdottir, B R; Geirsson, R T; Magnusdottir, S D; Dieben, Th O M
Citation:
Contraception 2004, 69(6):461-7
Issue Date:
1-Jun-2004
Abstract:
This open-label, nonrandomized study compared changes in hemostatic variables during NuvaRing and oral levonorgestrel 150 microg/ethinylestradiol 30 microg (LNG/EE) use for six cycles. Eighty-seven women started the study, 44 with NuvaRing and 43 with the LNG/EE oral contraceptive. For most procoagulation variables, there was no difference between NuvaRing and oral LNG/EE; only Factor VII levels increased in the NuvaRing group and decreased in the LNG/EE group. The majority of assessed variables show that anticoagulation and fibrinolytic activity was comparable between the NuvaRing and oral LNG/EE groups. Antithrombin activity and protein C activity both tended to be higher with NuvaRing. Levels of tissue plasminogen activator decreased in both groups but the reduction was smaller with NuvaRing. There were no significant differences in fibrin turnover between the treatment groups. The data show that both NuvaRing and oral LNG/EE are associated with a minimal effect on hemostatic variables.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6T5P-4CDFJRK-7/2/77edc070ca23335e593cb8197419e969

Full metadata record

DC FieldValue Language
dc.contributor.authorMagnusdottir, E M-
dc.contributor.authorBjarnadottir, R I-
dc.contributor.authorOnundarson, P T-
dc.contributor.authorGudmundsdottir, B R-
dc.contributor.authorGeirsson, R T-
dc.contributor.authorMagnusdottir, S D-
dc.contributor.authorDieben, Th O M-
dc.date.accessioned2007-11-05T15:26:14Z-
dc.date.available2007-11-05T15:26:14Z-
dc.date.issued2004-06-01-
dc.date.submitted2007-11-05-
dc.identifier.citationContraception 2004, 69(6):461-7en
dc.identifier.issn0010-7824-
dc.identifier.pmid15157790-
dc.identifier.doi10.1016/j.contraception.2003.12.010-
dc.identifier.otherHEM12-
dc.identifier.otherGYN12-
dc.identifier.urihttp://hdl.handle.net/2336/14470-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThis open-label, nonrandomized study compared changes in hemostatic variables during NuvaRing and oral levonorgestrel 150 microg/ethinylestradiol 30 microg (LNG/EE) use for six cycles. Eighty-seven women started the study, 44 with NuvaRing and 43 with the LNG/EE oral contraceptive. For most procoagulation variables, there was no difference between NuvaRing and oral LNG/EE; only Factor VII levels increased in the NuvaRing group and decreased in the LNG/EE group. The majority of assessed variables show that anticoagulation and fibrinolytic activity was comparable between the NuvaRing and oral LNG/EE groups. Antithrombin activity and protein C activity both tended to be higher with NuvaRing. Levels of tissue plasminogen activator decreased in both groups but the reduction was smaller with NuvaRing. There were no significant differences in fibrin turnover between the treatment groups. The data show that both NuvaRing and oral LNG/EE are associated with a minimal effect on hemostatic variables.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6T5P-4CDFJRK-7/2/77edc070ca23335e593cb8197419e969en
dc.subject.meshAdministration, Oralen
dc.subject.meshBlood Coagulationen
dc.subject.meshContraceptive Devices, Femaleen
dc.subject.meshContraceptives, Oral, Combineden
dc.subject.meshEthinyl Estradiolen
dc.subject.meshFemaleen
dc.subject.meshFactor VIIen
dc.subject.meshHemostasisen
dc.subject.meshLevonorgestrelen
dc.titleThe contraceptive vaginal ring (NuvaRing) and hemostasis: a comparative studyen
dc.typeArticleen
dc.identifier.journalContraceptionen
dc.format.digYES-
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