Increasing glucose levels and BMI predict future heart failure Experience from the Reykjavík Study

2.50
Hdl Handle:
http://hdl.handle.net/2336/14497
Title:
Increasing glucose levels and BMI predict future heart failure Experience from the Reykjavík Study
Authors:
Thrainsdottir, I S; Aspelund, T; Gudnason, V; Malmberg, K; Sigurdsson, G; Thorgeirsson, G; Hardarson, T; Rydén, L
Citation:
Eur. J. Heart Fail. 2007, 9(10):1051-7
Issue Date:
1-Oct-2007
Abstract:
BACKGROUND: Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS: 7060 subjects with two or more visits in the Reykjavík Study were followed-during 30 years from 1967. All underwent oral glucose tolerance tests. Disease status was defined according to the glycaemic level and presence of heart failure. The incidence and predictive factors for these diseases were determined. FINDINGS: Age and sex standardized incidence of heart failure was 5.3/1000/year, of diabetes 4.6/1000/year and abnormal glucose regulation 12.6/1000/year. Body mass index (BMI) and fasting glucose predicted the development of these conditions (p<0.001). Increasing fasting glucose by 1 mmol/l increased the risk for heart failure by 14% (p=0.04) after adjusting for IHD, BMI and other risk factors for CVD. There was a strong association between diabetes and heart failure, OR 3.0 (2.3-4.0), and abnormal glucose regulation and heart failure, OR 1.8 (1.5-2.3). Diabetes and heart failure were, however, not independent predictors of each other. INTERPRETATION: There was an independent relationship between increases in fasting glucose and development of heart failure. BMI was a strong predictor of heart failure. Although fasting glucose and BMI were significant risk factors for glucose disturbances and heart failure the conditions themselves did not independently predict each other.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://eurjhf.oxfordjournals.org/content/9/10/1051.abstract

Full metadata record

DC FieldValue Language
dc.contributor.authorThrainsdottir, I S-
dc.contributor.authorAspelund, T-
dc.contributor.authorGudnason, V-
dc.contributor.authorMalmberg, K-
dc.contributor.authorSigurdsson, G-
dc.contributor.authorThorgeirsson, G-
dc.contributor.authorHardarson, T-
dc.contributor.authorRydén, L-
dc.date.accessioned2007-11-07T11:24:17Z-
dc.date.available2007-11-07T11:24:17Z-
dc.date.issued2007-10-01-
dc.date.submitted2007-11-07-
dc.identifier.citationEur. J. Heart Fail. 2007, 9(10):1051-7en
dc.identifier.issn1388-9842-
dc.identifier.pmid17765010-
dc.identifier.doi10.1016/j.ejheart.2007.07.017-
dc.identifier.urihttp://hdl.handle.net/2336/14497-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractBACKGROUND: Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS: 7060 subjects with two or more visits in the Reykjavík Study were followed-during 30 years from 1967. All underwent oral glucose tolerance tests. Disease status was defined according to the glycaemic level and presence of heart failure. The incidence and predictive factors for these diseases were determined. FINDINGS: Age and sex standardized incidence of heart failure was 5.3/1000/year, of diabetes 4.6/1000/year and abnormal glucose regulation 12.6/1000/year. Body mass index (BMI) and fasting glucose predicted the development of these conditions (p<0.001). Increasing fasting glucose by 1 mmol/l increased the risk for heart failure by 14% (p=0.04) after adjusting for IHD, BMI and other risk factors for CVD. There was a strong association between diabetes and heart failure, OR 3.0 (2.3-4.0), and abnormal glucose regulation and heart failure, OR 1.8 (1.5-2.3). Diabetes and heart failure were, however, not independent predictors of each other. INTERPRETATION: There was an independent relationship between increases in fasting glucose and development of heart failure. BMI was a strong predictor of heart failure. Although fasting glucose and BMI were significant risk factors for glucose disturbances and heart failure the conditions themselves did not independently predict each other.en
dc.language.isoenen
dc.publisherElsevier Scienceen
dc.relation.urlhttp://eurjhf.oxfordjournals.org/content/9/10/1051.abstracten
dc.subject.meshBody Mass Indexen
dc.subject.meshCardiovascular Diseasesen
dc.subject.meshHeart Failureen
dc.titleIncreasing glucose levels and BMI predict future heart failure Experience from the Reykjavík Studyen
dc.typeArticleen
dc.identifier.journalEuropean journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiologyen
dc.format.digYES-

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