2.50
Hdl Handle:
http://hdl.handle.net/2336/14508
Title:
Proteome analysis of vernix caseosa
Authors:
Tollin, Maria; Jägerbrink, Theres; Haraldsson, Asgeir; Agerberth, Birgitta; Jörnvall, Hans
Citation:
Pediatr. Res. 2006, 60(4):430-4
Issue Date:
1-Oct-2006
Abstract:
Vernix caseosa (vernix) is a white creamy substance covering the skin of the fetus during the last trimester of pregnancy. The function of vernix has long been debated but no consensus has been reached. We here report a proteome analysis of vernix using two-dimensional gel electrophoresis, matrix-assisted laser desorption/ionization mass spectrometry and liquid chromatography coupled to tandem mass spectrometry. We have identified 41 proteins, of which 25 are novel to vernix. Notably, 39% of the identified vernix proteins are components of innate immunity, and 29% have direct antimicrobial properties. These results form a substantial contribution to the knowledge of vernix composition and demonstrate that antimicrobial protection of the fetus and the newborn child is a major and important function of vernix.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1203/01.pdr.0000238253.51224.d7

Full metadata record

DC FieldValue Language
dc.contributor.authorTollin, Maria-
dc.contributor.authorJägerbrink, Theres-
dc.contributor.authorHaraldsson, Asgeir-
dc.contributor.authorAgerberth, Birgitta-
dc.contributor.authorJörnvall, Hans-
dc.date.accessioned2007-11-08T14:45:58Z-
dc.date.available2007-11-08T14:45:58Z-
dc.date.issued2006-10-01-
dc.date.submitted2007-11-08-
dc.identifier.citationPediatr. Res. 2006, 60(4):430-4en
dc.identifier.issn0031-3998-
dc.identifier.pmid16940245-
dc.identifier.doi10.1203/01.pdr.0000238253.51224.d7-
dc.identifier.urihttp://hdl.handle.net/2336/14508-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractVernix caseosa (vernix) is a white creamy substance covering the skin of the fetus during the last trimester of pregnancy. The function of vernix has long been debated but no consensus has been reached. We here report a proteome analysis of vernix using two-dimensional gel electrophoresis, matrix-assisted laser desorption/ionization mass spectrometry and liquid chromatography coupled to tandem mass spectrometry. We have identified 41 proteins, of which 25 are novel to vernix. Notably, 39% of the identified vernix proteins are components of innate immunity, and 29% have direct antimicrobial properties. These results form a substantial contribution to the knowledge of vernix composition and demonstrate that antimicrobial protection of the fetus and the newborn child is a major and important function of vernix.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://dx.doi.org/10.1203/01.pdr.0000238253.51224.d7en
dc.subject.meshChromatography, Liquiden
dc.subject.meshElectrophoresis, Gel, Two-Dimensionalen
dc.subject.meshInfant, Newbornen
dc.subject.meshProteinsen
dc.subject.meshProteomeen
dc.subject.meshSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationen
dc.subject.meshVernix Caseosaen
dc.titleProteome analysis of vernix caseosaen
dc.typeArticleen
dc.identifier.journalPediatric researchen
dc.format.digYES-

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