Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms

2.50
Hdl Handle:
http://hdl.handle.net/2336/14516
Title:
Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms
Authors:
Svendsen, Kristina B; Andersen, Steen; Arnason, Sigurdur; Arnér, Staffan; Breivik, Harald; Heiskanen, Tarja; Kalso, Eija; Kongsgaard, Ulf E; Sjogren, Per; Strang, Peter; Bach, Flemming W; Jensen, Troels S
Citation:
Eur J Pain 2005, 9(2):195-206
Issue Date:
1-Apr-2005
Abstract:
Breakthrough pain or transient worsening of pain in patients with an ongoing steady pain is a well known feature in cancer pain patients, but it is also seen in non-malignant pain conditions with involvement of nerves, muscles, bones or viscera. Continuous and intermittent pain seems to be a general feature of these different pain conditions, and this raises the possibility of one or several common mechanisms underlying breakthrough pain in malignant and non-malignant disorders. Although the mechanisms of spontaneous ongoing pain and intermittent flares of pain (BTP) may be difficult to separate, we suggest that peripheral and/or central sensitization (hyperexcitability) may play a major role in many causes of BTP. Mechanical stimuli (e.g. micro-fractures) changes in chemical environments and release of tumour growth factors may initiate sensitization both peripherally and centrally. It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WF3-4CP68R7-1/2/05224b60895cb4aa489a22cb8d79c708

Full metadata record

DC FieldValue Language
dc.contributor.authorSvendsen, Kristina B-
dc.contributor.authorAndersen, Steen-
dc.contributor.authorArnason, Sigurdur-
dc.contributor.authorArnér, Staffan-
dc.contributor.authorBreivik, Harald-
dc.contributor.authorHeiskanen, Tarja-
dc.contributor.authorKalso, Eija-
dc.contributor.authorKongsgaard, Ulf E-
dc.contributor.authorSjogren, Per-
dc.contributor.authorStrang, Peter-
dc.contributor.authorBach, Flemming W-
dc.contributor.authorJensen, Troels S-
dc.date.accessioned2007-11-12T15:02:57Z-
dc.date.available2007-11-12T15:02:57Z-
dc.date.issued2005-04-01-
dc.date.submitted2007-11-12-
dc.identifier.citationEur J Pain 2005, 9(2):195-206en
dc.identifier.issn1090-3801-
dc.identifier.pmid15737812-
dc.identifier.doi10.1016/j.ejpain.2004.06.001-
dc.identifier.urihttp://hdl.handle.net/2336/14516-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBreakthrough pain or transient worsening of pain in patients with an ongoing steady pain is a well known feature in cancer pain patients, but it is also seen in non-malignant pain conditions with involvement of nerves, muscles, bones or viscera. Continuous and intermittent pain seems to be a general feature of these different pain conditions, and this raises the possibility of one or several common mechanisms underlying breakthrough pain in malignant and non-malignant disorders. Although the mechanisms of spontaneous ongoing pain and intermittent flares of pain (BTP) may be difficult to separate, we suggest that peripheral and/or central sensitization (hyperexcitability) may play a major role in many causes of BTP. Mechanical stimuli (e.g. micro-fractures) changes in chemical environments and release of tumour growth factors may initiate sensitization both peripherally and centrally. It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain.en
dc.language.isoenen
dc.publisherSaundersen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WF3-4CP68R7-1/2/05224b60895cb4aa489a22cb8d79c708en
dc.subject.meshPainen
dc.subject.meshPain Measurementen
dc.subject.meshPrevalenceen
dc.subject.meshSomatosensory Disordersen
dc.titleBreakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanismsen
dc.typeArticleen
dc.identifier.eissn1532-2149-
dc.identifier.journalEuropean journal of pain (London, England)en
dc.format.digYES-

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