Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

2.50
Hdl Handle:
http://hdl.handle.net/2336/14522
Title:
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
Authors:
Gudmundsson, Julius; Sulem, Patrick; Manolescu, Andrei; Amundadottir, Laufey T; Gudbjartsson, Daniel; Helgason, Agnar; Rafnar, Thorunn; Bergthorsson, Jon T; Agnarsson, Bjarni A; Baker, Adam; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Jakobsdottir, Margret; Xu, Jianfeng; Blondal, Thorarinn; Kostic, Jelena; Sun, Jielin; Ghosh, Shyamali; Stacey, Simon N; Mouy, Magali; Saemundsdottir, Jona; Backman, Valgerdur M; Kristjansson, Kristleifur; Tres, Alejandro; Partin, Alan W; Albers-Akkers, Marjo T; Godino-Ivan Marcos, Javier; Walsh, Patrick C; Swinkels, Dorine W; Navarrete, Sebastian; Isaacs, Sarah D; Aben, Katja K; Graif, Theresa; Cashy, John; Ruiz-Echarri, Manuel; Wiley, Kathleen E; Suarez, Brian K; Witjes, J Alfred; Frigge, Mike; Ober, Carole; Jonsson, Eirikur; Einarsson, Gudmundur V; Mayordomo, Jose I; Kiemeney, Lambertus A; Isaacs, William B; Catalona, William J; Barkardottir, Rosa B; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
Citation:
Nat. Genet. 2007, 39(5):631-7
Issue Date:
1-May-2007
Abstract:
Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://dx.doi.org/10.1038/ng1999

Full metadata record

DC FieldValue Language
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorAmundadottir, Laufey T-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorHelgason, Agnar-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorBergthorsson, Jon T-
dc.contributor.authorAgnarsson, Bjarni A-
dc.contributor.authorBaker, Adam-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorBenediktsdottir, Kristrun R-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorXu, Jianfeng-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorKostic, Jelena-
dc.contributor.authorSun, Jielin-
dc.contributor.authorGhosh, Shyamali-
dc.contributor.authorStacey, Simon N-
dc.contributor.authorMouy, Magali-
dc.contributor.authorSaemundsdottir, Jona-
dc.contributor.authorBackman, Valgerdur M-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorTres, Alejandro-
dc.contributor.authorPartin, Alan W-
dc.contributor.authorAlbers-Akkers, Marjo T-
dc.contributor.authorGodino-Ivan Marcos, Javier-
dc.contributor.authorWalsh, Patrick C-
dc.contributor.authorSwinkels, Dorine W-
dc.contributor.authorNavarrete, Sebastian-
dc.contributor.authorIsaacs, Sarah D-
dc.contributor.authorAben, Katja K-
dc.contributor.authorGraif, Theresa-
dc.contributor.authorCashy, John-
dc.contributor.authorRuiz-Echarri, Manuel-
dc.contributor.authorWiley, Kathleen E-
dc.contributor.authorSuarez, Brian K-
dc.contributor.authorWitjes, J Alfred-
dc.contributor.authorFrigge, Mike-
dc.contributor.authorOber, Carole-
dc.contributor.authorJonsson, Eirikur-
dc.contributor.authorEinarsson, Gudmundur V-
dc.contributor.authorMayordomo, Jose I-
dc.contributor.authorKiemeney, Lambertus A-
dc.contributor.authorIsaacs, William B-
dc.contributor.authorCatalona, William J-
dc.contributor.authorBarkardottir, Rosa B-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2007-11-08T09:00:44Z-
dc.date.available2007-11-08T09:00:44Z-
dc.date.issued2007-05-01-
dc.date.submitted2007-11-08-
dc.identifier.citationNat. Genet. 2007, 39(5):631-7en
dc.identifier.issn1061-4036-
dc.identifier.pmid17401366-
dc.identifier.doi10.1038/ng1999-
dc.identifier.urihttp://hdl.handle.net/2336/14522-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractProstate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng1999en
dc.subject.meshPubMed - in processen
dc.titleGenome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.en
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.