2.50
Hdl Handle:
http://hdl.handle.net/2336/14665
Title:
Mortality in systemic lupus erythematosus
Authors:
Bernatsky, S; Boivin, J-F; Joseph, L; Manzi, S; Ginzler, E; Gladman, D D; Urowitz, M; Fortin, P R; Petri, M; Barr, S; Gordon, C; Bae, S-C; Isenberg, D; Zoma, A; Aranow, C; Dooley, M-A; Nived, O; Sturfelt, G; Steinsson, K; Alarcón, G; Senécal, J-L; Zummer, M; Hanly, J; Ensworth, S; Pope, J; Edworthy, S; Rahman, A; Sibley, J; El-Gabalawy, H; McCarthy, T; St Pierre, Y; Clarke, A; Ramsey-Goldman, R
Citation:
Arthritis Rheum. 2006, 54(8):2550-7
Issue Date:
1-Aug-2006
Abstract:
OBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration <1 year, or black/African American race. There was a dramatic decrease in total SMR estimates across calendar-year periods, which was demonstrable for specific causes including death due to infections and death due to renal disorders. However, the SMR due to circulatory diseases tended to increase slightly from the 1970s to the year 2001. CONCLUSION: Our data from a very large multicenter international cohort emphasize what has been demonstrated previously in smaller samples. These results highlight the increased mortality rate in SLE patients compared with the general population, and they suggest particular risk associated with female sex, younger age, shorter SLE duration, and black/African American race. The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished.
Description:
To access Publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://dx.doi.org/10.1002/art.21955

Full metadata record

DC FieldValue Language
dc.contributor.authorBernatsky, S-
dc.contributor.authorBoivin, J-F-
dc.contributor.authorJoseph, L-
dc.contributor.authorManzi, S-
dc.contributor.authorGinzler, E-
dc.contributor.authorGladman, D D-
dc.contributor.authorUrowitz, M-
dc.contributor.authorFortin, P R-
dc.contributor.authorPetri, M-
dc.contributor.authorBarr, S-
dc.contributor.authorGordon, C-
dc.contributor.authorBae, S-C-
dc.contributor.authorIsenberg, D-
dc.contributor.authorZoma, A-
dc.contributor.authorAranow, C-
dc.contributor.authorDooley, M-A-
dc.contributor.authorNived, O-
dc.contributor.authorSturfelt, G-
dc.contributor.authorSteinsson, K-
dc.contributor.authorAlarcón, G-
dc.contributor.authorSenécal, J-L-
dc.contributor.authorZummer, M-
dc.contributor.authorHanly, J-
dc.contributor.authorEnsworth, S-
dc.contributor.authorPope, J-
dc.contributor.authorEdworthy, S-
dc.contributor.authorRahman, A-
dc.contributor.authorSibley, J-
dc.contributor.authorEl-Gabalawy, H-
dc.contributor.authorMcCarthy, T-
dc.contributor.authorSt Pierre, Y-
dc.contributor.authorClarke, A-
dc.contributor.authorRamsey-Goldman, R-
dc.date.accessioned2007-11-22T09:05:26Z-
dc.date.available2007-11-22T09:05:26Z-
dc.date.issued2006-08-01-
dc.date.submitted2007-11-22-
dc.identifier.citationArthritis Rheum. 2006, 54(8):2550-7en
dc.identifier.issn0004-3591-
dc.identifier.pmid16868977-
dc.identifier.doi10.1002/art.21955-
dc.identifier.urihttp://hdl.handle.net/2336/14665-
dc.descriptionTo access Publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractOBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration <1 year, or black/African American race. There was a dramatic decrease in total SMR estimates across calendar-year periods, which was demonstrable for specific causes including death due to infections and death due to renal disorders. However, the SMR due to circulatory diseases tended to increase slightly from the 1970s to the year 2001. CONCLUSION: Our data from a very large multicenter international cohort emphasize what has been demonstrated previously in smaller samples. These results highlight the increased mortality rate in SLE patients compared with the general population, and they suggest particular risk associated with female sex, younger age, shorter SLE duration, and black/African American race. The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished.en
dc.language.isoenen
dc.publisherWiley-Liss, Inc.en
dc.relation.urlhttp://dx.doi.org/10.1002/art.21955en
dc.subject.meshCause of Deathen
dc.subject.meshIcelanden
dc.subject.meshInternational Cooperationen
dc.subject.meshLupus Erythematosus, Systemicen
dc.subject.meshRegistriesen
dc.subject.meshSurvival Rateen
dc.titleMortality in systemic lupus erythematosusen
dc.typeArticleen
dc.format.digYES-

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