2.50
Hdl Handle:
http://hdl.handle.net/2336/14690
Title:
Anxiety with panic disorder linked to chromosome 9q in Iceland
Authors:
Thorgeirsson, Thorgeir E; Oskarsson, Högni; Desnica, Natasa; Kostic, Jelena Pop; Stefansson, Jon G; Kolbeinsson, Halldor; Lindal, Eirikur; Gagunashvili, Nikolai; Frigge, Michael L; Kong, Augustine; Stefansson, Kari; Gulcher, Jeffrey R
Citation:
Am. J. Hum. Genet. 2003, 72(5):1221-30
Issue Date:
1-May-2003
Abstract:
The results of a genomewide scan for genes conferring susceptibility to anxiety disorders in the Icelandic population are described. The aim of the study was to locate genes that predispose to anxiety by utilizing the extensive genealogical records and the relative homogeneity of the Icelandic population. Participants were recruited in two stages: (1) Initial case-identification by a population screening for anxiety disorders, using the Stamm Screening Questionnaire, was followed by aggregation into extended families, with the help of our genealogy database; and (2) those who fulfilled the diagnostic and family aggregation criteria underwent a more detailed diagnostic workup based on the Composite International Diagnostic Interview. Screening for anxiety in close relatives also identified additional affected members within the families. After genotyping was performed with 976 microsatellite markers, affected-only linkage analysis was done, and allele-sharing LOD scores were calculated using the program Allegro. Linkage analysis of 25 extended families, in each of which at least one affected individual had panic disorder (PD), resulted in a LOD score of 4.18 at D9S271, on chromosome 9q31. The intermarker distance was 4.4 cM on average, whereas it was 1.5 cM in the linked region as additional markers were added to increase the information content. The linkage results may be relevant not only to PD but also to anxiety in general, since our linkage study included patients with other forms of anxiety.
Description:
To access publisher version of this article. Please click on the hyperlink in Additional Links field; To access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this page
Additional Links:
http://www.journals.uchicago.edu/doi/abs/10.1086/375141

Full metadata record

DC FieldValue Language
dc.contributor.authorThorgeirsson, Thorgeir E-
dc.contributor.authorOskarsson, Högni-
dc.contributor.authorDesnica, Natasa-
dc.contributor.authorKostic, Jelena Pop-
dc.contributor.authorStefansson, Jon G-
dc.contributor.authorKolbeinsson, Halldor-
dc.contributor.authorLindal, Eirikur-
dc.contributor.authorGagunashvili, Nikolai-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorGulcher, Jeffrey R-
dc.date.accessioned2007-11-22T10:25:32Z-
dc.date.available2007-11-22T10:25:32Z-
dc.date.issued2003-05-01-
dc.date.submitted2007-11-22-
dc.identifier.citationAm. J. Hum. Genet. 2003, 72(5):1221-30en
dc.identifier.issn0002-9297-
dc.identifier.pmid12679899-
dc.identifier.doi10.1086/375141-
dc.identifier.urihttp://hdl.handle.net/2336/14690-
dc.descriptionTo access publisher version of this article. Please click on the hyperlink in Additional Links fielden
dc.descriptionTo access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this pageen
dc.description.abstractThe results of a genomewide scan for genes conferring susceptibility to anxiety disorders in the Icelandic population are described. The aim of the study was to locate genes that predispose to anxiety by utilizing the extensive genealogical records and the relative homogeneity of the Icelandic population. Participants were recruited in two stages: (1) Initial case-identification by a population screening for anxiety disorders, using the Stamm Screening Questionnaire, was followed by aggregation into extended families, with the help of our genealogy database; and (2) those who fulfilled the diagnostic and family aggregation criteria underwent a more detailed diagnostic workup based on the Composite International Diagnostic Interview. Screening for anxiety in close relatives also identified additional affected members within the families. After genotyping was performed with 976 microsatellite markers, affected-only linkage analysis was done, and allele-sharing LOD scores were calculated using the program Allegro. Linkage analysis of 25 extended families, in each of which at least one affected individual had panic disorder (PD), resulted in a LOD score of 4.18 at D9S271, on chromosome 9q31. The intermarker distance was 4.4 cM on average, whereas it was 1.5 cM in the linked region as additional markers were added to increase the information content. The linkage results may be relevant not only to PD but also to anxiety in general, since our linkage study included patients with other forms of anxiety.en
dc.language.isoenen
dc.publisherUniversity of Chicago Pressen
dc.relation.urlhttp://www.journals.uchicago.edu/doi/abs/10.1086/375141en
dc.subject.meshAnxietyen
dc.subject.meshChromosomes, Human, Pair 9en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshIcelanden
dc.subject.meshLinkage (Genetics)en
dc.subject.meshPanic Disorderen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshQuestionnairesen
dc.titleAnxiety with panic disorder linked to chromosome 9q in Icelanden
dc.typeArticleen
dc.contributor.departmentdeCode Genetics, Reykjavík, Iceland. thorgeir@decode.isen
dc.identifier.journalAmerican journal of human geneticsen
dc.format.digYES-

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