2.50
Hdl Handle:
http://hdl.handle.net/2336/15334
Title:
The genetic basis of psoriasis
Authors:
Valdimarsson, Helgi
Citation:
The genetic basis of psoriasis 2007, 25(6):563-7
Issue Date:
1-Dec-2007
Abstract:
For a complex genetic disease, psoriasis has a high penetration within families and a concordance rate of up to 70% in identical twins. Despite this and the endeavors of many research groups for more than a decade, no susceptibility allele has so far been unequivocally identified, although about 20 genetic loci associated with psoriasis have been reported from linkage-based studies. Moreover, only 1 of these linkage-based loci, PSORS1, that includes the HLA-C gene on chromosome 6p21, has been universally confirmed. Very recent data strongly indicate that HLA-Cw*0602 is the susceptibility allele in this locus, a finding that is consistent with the notion that the pathogenesis of psoriasis involves autoantigen recognition by epidermal CD8+ T lymphocytes. Several candidate genes in some of the other 7 PSORS designated loci are currently being evaluated. The relative lack of success in elucidating the genetic basis of psoriasis highlights the formidable challenge of dissecting the genetic basis of diseases with a complex mode of inheritance.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link
Additional Links:
http://www.sciencedirect.com/science/article/B6T5G-4R4VVPN-D/2/b27ac106337d1ac836e2e157a840f23c

Full metadata record

DC FieldValue Language
dc.contributor.authorValdimarsson, Helgi-
dc.date.accessioned2007-12-17T11:36:20Z-
dc.date.available2007-12-17T11:36:20Z-
dc.date.issued2007-12-01-
dc.date.submitted2007-12-17-
dc.identifier.citationThe genetic basis of psoriasis 2007, 25(6):563-7en
dc.identifier.issn0738-081X-
dc.identifier.pmid18021893-
dc.identifier.doi10.1016/j.clindermatol.2007.08.010-
dc.identifier.urihttp://hdl.handle.net/2336/15334-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Linken
dc.description.abstractFor a complex genetic disease, psoriasis has a high penetration within families and a concordance rate of up to 70% in identical twins. Despite this and the endeavors of many research groups for more than a decade, no susceptibility allele has so far been unequivocally identified, although about 20 genetic loci associated with psoriasis have been reported from linkage-based studies. Moreover, only 1 of these linkage-based loci, PSORS1, that includes the HLA-C gene on chromosome 6p21, has been universally confirmed. Very recent data strongly indicate that HLA-Cw*0602 is the susceptibility allele in this locus, a finding that is consistent with the notion that the pathogenesis of psoriasis involves autoantigen recognition by epidermal CD8+ T lymphocytes. Several candidate genes in some of the other 7 PSORS designated loci are currently being evaluated. The relative lack of success in elucidating the genetic basis of psoriasis highlights the formidable challenge of dissecting the genetic basis of diseases with a complex mode of inheritance.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6T5G-4R4VVPN-D/2/b27ac106337d1ac836e2e157a840f23cen
dc.subject.meshPubMed - in processen
dc.subject.meshPsoriasisen
dc.subject.meshGeneticsen
dc.titleThe genetic basis of psoriasisen
dc.typeArticleen
dc.contributor.departmentLandspítali Háskólasjúkrahús, University Hospital, Hringbraut, 101 Reykjavík, Iceland. helgiv@landspitali.isen
dc.identifier.journalClinics in dermatologyen

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