Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study.

2.50
Hdl Handle:
http://hdl.handle.net/2336/15495
Title:
Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study.
Authors:
Sigmundsson, Thordur; Maier, Michael; Toone, Brian K; Williams, Steven C R; Simmons, Andrew; Greenwood, Kathryn; Ron, Maria A
Citation:
Schizophr Res. 2003, 64(1):63-71
Issue Date:
1-Nov-2003
Abstract:
INTRODUCTION: Clinical, neuropsychological and functional neuroimaging studies in schizophrenia suggest impaired frontal lobe function, especially of the dorsolateral prefrontal region (DLPFR). This dysfunction has in particular been associated with negative or "deficit" symptoms. Despite these findings, morphological studies have failed to show consistent structural abnormalities in the frontal lobe. This may be because existing techniques are not sensitive enough to detect structural abnormalities or that dysfunction in the frontal lobe is caused by lesions elsewhere. We used volume-localised proton magnetic resonance spectroscopy (1H-MRS) to measure N-acetylaspartate (NAA), a neuronal marker, to evaluate the neuronal integrity of the dorsolateral prefrontal region in schizophrenic patients with persistent negative symptoms and in healthy comparison subjects. METHOD: Twenty-five patients who fulfilled DSM-IV criteria for schizophrenia and met the criteria for the Deficit syndrome were compared to 26 healthy controls matched for age and gender. Bilateral proton MR spectra were collected from a 2-cm(3) volume in the dorsolateral prefrontal region and the absolute concentrations of N-acetylaspartate, choline (Cho) and creatine+phosphocreatine (Cr+PCr) were measured. RESULTS: There was a significant negative correlation between severity of symptoms and NAA concentration in the schizophrenic patients. This was more marked for positive symptoms and for general psychopathology than for negative symptoms. There was also a significant correlation between NAA concentration and social functioning within the schizophrenic group. There were no significant differences between the two groups for the three metabolites. CONCLUSIONS: The negative association between severity of symptoms and NAA in schizophrenic patients and an association of NAA with social functioning suggest that NAA may be an indicator of disease severity. The lack of significant mean difference in NAA between the two groups suggests that there is no marked neuronal loss in the dorsolateral prefrontal region in schizophrenia.
Description:
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Additional Links:
http://www.sciencedirect.com/science/article/B6TC2-485V12D-B/2/901912a88c1e35750b90e7e5f9f70efd

Full metadata record

DC FieldValue Language
dc.contributor.authorSigmundsson, Thordur-
dc.contributor.authorMaier, Michael-
dc.contributor.authorToone, Brian K-
dc.contributor.authorWilliams, Steven C R-
dc.contributor.authorSimmons, Andrew-
dc.contributor.authorGreenwood, Kathryn-
dc.contributor.authorRon, Maria A-
dc.date.accessioned2007-12-21T14:21:03Z-
dc.date.available2007-12-21T14:21:03Z-
dc.date.issued2003-11-01-
dc.date.submitted2007-12-21-
dc.identifier.citationSchizophr Res. 2003, 64(1):63-71en
dc.identifier.issn0920-9964-
dc.identifier.pmid14511802-
dc.identifier.doi10.1016/S0920-9964(02)00533-9-
dc.identifier.urihttp://hdl.handle.net/2336/15495-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractINTRODUCTION: Clinical, neuropsychological and functional neuroimaging studies in schizophrenia suggest impaired frontal lobe function, especially of the dorsolateral prefrontal region (DLPFR). This dysfunction has in particular been associated with negative or "deficit" symptoms. Despite these findings, morphological studies have failed to show consistent structural abnormalities in the frontal lobe. This may be because existing techniques are not sensitive enough to detect structural abnormalities or that dysfunction in the frontal lobe is caused by lesions elsewhere. We used volume-localised proton magnetic resonance spectroscopy (1H-MRS) to measure N-acetylaspartate (NAA), a neuronal marker, to evaluate the neuronal integrity of the dorsolateral prefrontal region in schizophrenic patients with persistent negative symptoms and in healthy comparison subjects. METHOD: Twenty-five patients who fulfilled DSM-IV criteria for schizophrenia and met the criteria for the Deficit syndrome were compared to 26 healthy controls matched for age and gender. Bilateral proton MR spectra were collected from a 2-cm(3) volume in the dorsolateral prefrontal region and the absolute concentrations of N-acetylaspartate, choline (Cho) and creatine+phosphocreatine (Cr+PCr) were measured. RESULTS: There was a significant negative correlation between severity of symptoms and NAA concentration in the schizophrenic patients. This was more marked for positive symptoms and for general psychopathology than for negative symptoms. There was also a significant correlation between NAA concentration and social functioning within the schizophrenic group. There were no significant differences between the two groups for the three metabolites. CONCLUSIONS: The negative association between severity of symptoms and NAA in schizophrenic patients and an association of NAA with social functioning suggest that NAA may be an indicator of disease severity. The lack of significant mean difference in NAA between the two groups suggests that there is no marked neuronal loss in the dorsolateral prefrontal region in schizophrenia.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6TC2-485V12D-B/2/901912a88c1e35750b90e7e5f9f70efden
dc.subject.meshAdulten
dc.subject.meshAspartic Aciden
dc.subject.meshBrain Mappingen
dc.subject.meshCholineen
dc.subject.meshCreatineen
dc.subject.meshDominance, Cerebralen
dc.subject.meshEnergy Metabolismen
dc.subject.meshFemaleen
dc.subject.meshFrontal Lobeen
dc.subject.meshHumansen
dc.subject.meshImage Processing, Computer-Assisteden
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMagnetic Resonance Spectroscopyen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPhosphocreatineen
dc.subject.meshPrefrontal Cortexen
dc.subject.meshPsychiatric Status Rating Scalesen
dc.subject.meshReference Valuesen
dc.subject.meshSchizophreniaen
dc.subject.meshSchizophrenic Psychologyen
dc.titleFrontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychological Medicine, Institute of Psychiatry, King's College, De Crespigny Park, London SE5 8AF, UK., Department of Psychiatry, Landspitalinn, University Hospital, 101 Reykjavik, Icelanden
dc.identifier.journalSchizophrenia researchen

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