Hyperphagia modifies FA profiles of plasma phospholipids, plasma FFA, and adipose tissue TAG

2.50
Hdl Handle:
http://hdl.handle.net/2336/15573
Title:
Hyperphagia modifies FA profiles of plasma phospholipids, plasma FFA, and adipose tissue TAG
Authors:
Skuladottir, Gudrun V; Olason, Pall I; Jonsson, Logi; Skarphedinsson, Jon O; Eriksdottir, Vedis H; Atlason, Palmi Th; Franzson, Leifur; Schiöth, Helgi B
Citation:
Lipids 2003, 38(11):1127-32
Issue Date:
1-Nov-2003
Abstract:
Hyperphagia was achieved by continuous intracerebroventricular infusion of a melanocortin receptor antagonist (HS024; Neosystem, Strasbourg, France) in rats. The effects of hyperphagia on FA composition and concentration of plasma phospholipids (PL), plasma FFA, and adipose tissue TAG were studied in rats for 8 d [short-term hyperphagia (STH); n = 8], or 28 d [long-term hyperphagia (LTH); n = 9]. The control rats were treated with artificial cerebrospinal fluid for 8 d (n = 8) or 28 d (n = 10). The rats were fed the same regular diet. In STH rats the plasma PL and fasting plasma FFA contained higher concentrations of saturated FA (SFA) and monounsaturated FA (MUFA), and plasma FFA contained lower n-6 PUFA than in the control rats. In LTH rats the plasma PL contained higher concentrations of SFA, MUFA, and n-3 PUFA and higher proportions of 16:1n-7 and 18:1n-9 at the expense of 18:2n-6 than in the control rats. In LTH rats the abundant dietary intake of 18:2n-6 did not enrich 18:2n-6 of the plasma PL or adipose tissue TAG. In LTH rats the fasting plasma FFA contained more than twofold higher concentrations of SFA and MUFA, and higher proportions of 16:1n-7 and 18:1n-9 at the expense of 18:2n-6 than in the control rats. This animal obesity model shows that LTH affects the FA composition and concentration of plasma PL, plasma FFA, and adipose tissue TAG, a result consistent with changes associated with increased risk of various diseases in humans. These results also demonstrate that LTH alters the FA composition of plasma PL and adipose tissue TAG in a way that does not reflect the FA composition of dietary fat.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.springerlink.com/content/8077kh2606070w7x

Full metadata record

DC FieldValue Language
dc.contributor.authorSkuladottir, Gudrun V-
dc.contributor.authorOlason, Pall I-
dc.contributor.authorJonsson, Logi-
dc.contributor.authorSkarphedinsson, Jon O-
dc.contributor.authorEriksdottir, Vedis H-
dc.contributor.authorAtlason, Palmi Th-
dc.contributor.authorFranzson, Leifur-
dc.contributor.authorSchiöth, Helgi B-
dc.date.accessioned2008-01-02T10:53:32Z-
dc.date.available2008-01-02T10:53:32Z-
dc.date.issued2003-11-01-
dc.date.submitted2007-01-02-
dc.identifier.citationLipids 2003, 38(11):1127-32en
dc.identifier.issn0024-4201-
dc.identifier.pmid14733357-
dc.identifier.doi10.1007/s11745-003-1170-1-
dc.identifier.urihttp://hdl.handle.net/2336/15573-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractHyperphagia was achieved by continuous intracerebroventricular infusion of a melanocortin receptor antagonist (HS024; Neosystem, Strasbourg, France) in rats. The effects of hyperphagia on FA composition and concentration of plasma phospholipids (PL), plasma FFA, and adipose tissue TAG were studied in rats for 8 d [short-term hyperphagia (STH); n = 8], or 28 d [long-term hyperphagia (LTH); n = 9]. The control rats were treated with artificial cerebrospinal fluid for 8 d (n = 8) or 28 d (n = 10). The rats were fed the same regular diet. In STH rats the plasma PL and fasting plasma FFA contained higher concentrations of saturated FA (SFA) and monounsaturated FA (MUFA), and plasma FFA contained lower n-6 PUFA than in the control rats. In LTH rats the plasma PL contained higher concentrations of SFA, MUFA, and n-3 PUFA and higher proportions of 16:1n-7 and 18:1n-9 at the expense of 18:2n-6 than in the control rats. In LTH rats the abundant dietary intake of 18:2n-6 did not enrich 18:2n-6 of the plasma PL or adipose tissue TAG. In LTH rats the fasting plasma FFA contained more than twofold higher concentrations of SFA and MUFA, and higher proportions of 16:1n-7 and 18:1n-9 at the expense of 18:2n-6 than in the control rats. This animal obesity model shows that LTH affects the FA composition and concentration of plasma PL, plasma FFA, and adipose tissue TAG, a result consistent with changes associated with increased risk of various diseases in humans. These results also demonstrate that LTH alters the FA composition of plasma PL and adipose tissue TAG in a way that does not reflect the FA composition of dietary fat.en
dc.language.isoenen
dc.publisherAmerican Oil Chemists Societyen
dc.relation.urlhttp://www.springerlink.com/content/8077kh2606070w7xen
dc.subject.meshAdipose Tissueen
dc.subject.meshAnimalsen
dc.subject.meshEnergy Intakeen
dc.subject.meshFatty Acids, Nonesterifieden
dc.subject.meshHyperphagiaen
dc.subject.meshMaleen
dc.subject.meshPhospholipidsen
dc.subject.meshRatsen
dc.subject.meshTriglyceridesen
dc.titleHyperphagia modifies FA profiles of plasma phospholipids, plasma FFA, and adipose tissue TAGen
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Icelanden
dc.identifier.journalLipidsen

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