2.50
Hdl Handle:
http://hdl.handle.net/2336/15592
Title:
Development of immunoglobulin A in infancy and childhood.
Authors:
Weemaes, C; Klasen, I; Göertz, J; Beldhuis-Valkis, M; Olafsson, O; Haraldsson, A
Citation:
Scand. J. Immunol 2003, 58(6):642-8
Issue Date:
1-Dec-2003
Abstract:
Serum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P < 0.001) during childhood. The salivary IgA1/IgA2 ratio tended to decrease during the same period; this trend is less apparent when omitting the youngest children. The salivary IgA1 and IgA2 output could be high, even in children with low levels of serum IgA. Only polymeric IgA was found in whole saliva. Interestingly, in serum, most IgA1 and IgA2 were polymeric during infancy. The proportion of polymeric IgA decreased, when the concentration of IgA increased. The polymeric form of IgA might provide the infant with better protection against invading microorganisms by activation of the innate immune mechanisms.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-3083.2003.01344.x

Full metadata record

DC FieldValue Language
dc.contributor.authorWeemaes, C-
dc.contributor.authorKlasen, I-
dc.contributor.authorGöertz, J-
dc.contributor.authorBeldhuis-Valkis, M-
dc.contributor.authorOlafsson, O-
dc.contributor.authorHaraldsson, A-
dc.date.accessioned2008-01-02T09:52:33Z-
dc.date.available2008-01-02T09:52:33Z-
dc.date.issued2003-12-01-
dc.date.submitted2008-01-02-
dc.identifier.citationScand. J. Immunol 2003, 58(6):642-8en
dc.identifier.issn0300-9475-
dc.identifier.pmid14636420-
dc.identifier.doi10.1111/j.1365-3083.2003.01344.x-
dc.identifier.urihttp://hdl.handle.net/2336/15592-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSerum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P < 0.001) during childhood. The salivary IgA1/IgA2 ratio tended to decrease during the same period; this trend is less apparent when omitting the youngest children. The salivary IgA1 and IgA2 output could be high, even in children with low levels of serum IgA. Only polymeric IgA was found in whole saliva. Interestingly, in serum, most IgA1 and IgA2 were polymeric during infancy. The proportion of polymeric IgA decreased, when the concentration of IgA increased. The polymeric form of IgA might provide the infant with better protection against invading microorganisms by activation of the innate immune mechanisms.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-3083.2003.01344.xen
dc.subject.meshAge Factorsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshHumansen
dc.subject.meshImmunoglobulin Aen
dc.subject.meshImmunoglobulin A, Secretoryen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshSalivaen
dc.titleDevelopment of immunoglobulin A in infancy and childhood.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands. c.weemaes@cukz.umcn.nlen
dc.identifier.journalScandinavian journal of immunologyen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.