2.50
Hdl Handle:
http://hdl.handle.net/2336/15740
Title:
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
Authors:
Gretarsdottir, Solveig; Thorleifsson, Gudmar; Reynisdottir, Sigridur Th; Manolescu, Andrei; Jonsdottir, Sif; Jonsdottir, Thorbjorg; Gudmundsdottir, Thorunn; Bjarnadottir, Sigrun M; Einarsson, Olafur B; Gudjonsdottir, Herdis M; Hawkins, Malcolm; Gudmundsson, Gudmundur; Gudmundsdottir, Hrefna; Andrason, Hjalti; Gudmundsdottir, Asta S; Sigurdardottir, Matthildur; Chou, Thomas T; Nahmias, Joseph; Goss, Shyamali; Sveinbjornsdottir, Sigurlaug; Valdimarsson, Einar M; Jakobsson, Finnbogi; Agnarsson, Uggi; Gudnason, Vilmundur; Thorgeirsson, Gudmundur; Fingerle, Jurgen; Gurney, Mark; Gudbjartsson, Daniel; Frigge, Michael L; Kong, Augustine; Stefansson, Kari; Gulcher, Jeffrey R
Citation:
Nat. Genet. 2003, 35(2):131-8
Issue Date:
1-Oct-2003
Abstract:
We previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped this locus and tested it for association with stroke. We found the strongest association in the gene encoding phosphodiesterase 4D (PDE4D), especially for carotid and cardiogenic stroke, the forms of stroke related to atherosclerosis. Notably, we found that haplotypes can be classified into three distinct groups: wild-type, at-risk and protective. We also observed a substantial disregulation of multiple PDE4D isoforms in affected individuals. We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng1245

Full metadata record

DC FieldValue Language
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorReynisdottir, Sigridur Th-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorJonsdottir, Sif-
dc.contributor.authorJonsdottir, Thorbjorg-
dc.contributor.authorGudmundsdottir, Thorunn-
dc.contributor.authorBjarnadottir, Sigrun M-
dc.contributor.authorEinarsson, Olafur B-
dc.contributor.authorGudjonsdottir, Herdis M-
dc.contributor.authorHawkins, Malcolm-
dc.contributor.authorGudmundsson, Gudmundur-
dc.contributor.authorGudmundsdottir, Hrefna-
dc.contributor.authorAndrason, Hjalti-
dc.contributor.authorGudmundsdottir, Asta S-
dc.contributor.authorSigurdardottir, Matthildur-
dc.contributor.authorChou, Thomas T-
dc.contributor.authorNahmias, Joseph-
dc.contributor.authorGoss, Shyamali-
dc.contributor.authorSveinbjornsdottir, Sigurlaug-
dc.contributor.authorValdimarsson, Einar M-
dc.contributor.authorJakobsson, Finnbogi-
dc.contributor.authorAgnarsson, Uggi-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorThorgeirsson, Gudmundur-
dc.contributor.authorFingerle, Jurgen-
dc.contributor.authorGurney, Mark-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorGulcher, Jeffrey R-
dc.date.accessioned2008-01-07T13:21:04Z-
dc.date.available2008-01-07T13:21:04Z-
dc.date.issued2003-10-01-
dc.date.submitted2007-01-07-
dc.identifier.citationNat. Genet. 2003, 35(2):131-8en
dc.identifier.issn1061-4036-
dc.identifier.pmid14517540-
dc.identifier.doi10.1038/ng1245-
dc.identifier.urihttp://hdl.handle.net/2336/15740-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe previously mapped susceptibility to stroke to chromosome 5q12. Here we finely mapped this locus and tested it for association with stroke. We found the strongest association in the gene encoding phosphodiesterase 4D (PDE4D), especially for carotid and cardiogenic stroke, the forms of stroke related to atherosclerosis. Notably, we found that haplotypes can be classified into three distinct groups: wild-type, at-risk and protective. We also observed a substantial disregulation of multiple PDE4D isoforms in affected individuals. We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke.en
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1038/ng1245en
dc.subject.mesh3',5'-Cyclic-AMP Phosphodiesterasesen
dc.subject.mesh5' Untranslated Regionsen
dc.subject.meshBase Sequenceen
dc.subject.meshBrain Ischemiaen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 5en
dc.subject.meshCyclic Nucleotide Phosphodiesterases, Type 3en
dc.subject.meshCyclic Nucleotide Phosphodiesterases, Type 4en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIsoenzymesen
dc.subject.meshLinkage Disequilibriumen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.titleThe gene encoding phosphodiesterase 4D confers risk of ischemic stroke.en
dc.typeArticleen

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