Cosmic radiation increases the risk of nuclear cataract in airline pilots: a population-based case-control study.

2.50
Hdl Handle:
http://hdl.handle.net/2336/15852
Title:
Cosmic radiation increases the risk of nuclear cataract in airline pilots: a population-based case-control study.
Authors:
Rafnsson, Vilhjalmur; Olafsdottir, Eydis; Hrafnkelsson, Jon; Sasaki, Hiroshi; Arnarsson, Arsaell; Jonasson, Fridbert
Citation:
Arch. Ophthalmol. 2005, 123(8):1102-5
Issue Date:
1-Aug-2005
Abstract:
BACKGROUND: Aviation involves exposure to ionizing radiation of cosmic origin. The association between lesions of the ocular lens and ionizing radiation is well-known. OBJECTIVE: To investigate whether employment as a commercial airline pilot and the resulting exposure to cosmic radiation is associated with lens opacification. METHODS: This is a population-based case-control study of 445 men. Lens opacification was classified into 4 types using the World Health Organization simplified grading system. These 4 types, serving as cases, included 71 persons with nuclear cataracts, 102 with cortical lens opacification, 69 with central optical zone involvement, and 32 with posterior subcapsular lens opacification. Control subjects are those with a different type of lens opacification or without lens opacification. Exposure was assessed based on employment time as pilots, annual number of hours flown on each aircraft type, time tables, flight profiles, and individual cumulative radiation doses (in millisieverts) calculated by a software program. Odds ratios were calculated using logistic regression. RESULTS: The odds ratio for nuclear cataract risk among cases and controls was 3.02 (95% confidence interval, 1.44-6.35) for pilots compared with nonpilots, adjusted for age, smoking status, and sunbathing habits. The odds ratio for nuclear cataract associated with estimation of cumulative radiation dose (in millisieverts) to the age of 40 years was 1.06 (95% confidence interval, 1.02-1.10), adjusted for age, smoking status, and sunbathing habits. CONCLUSION: The association between the cosmic radiation exposure of pilots and the risk of nuclear cataracts, adjusted for age, smoking status, and sunbathing habits, indicates that cosmic radiation may be a causative factor in nuclear cataracts among commercial airline pilots.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://archopht.ama-assn.org/cgi/content/abstract/123/8/1102

Full metadata record

DC FieldValue Language
dc.contributor.authorRafnsson, Vilhjalmur-
dc.contributor.authorOlafsdottir, Eydis-
dc.contributor.authorHrafnkelsson, Jon-
dc.contributor.authorSasaki, Hiroshi-
dc.contributor.authorArnarsson, Arsaell-
dc.contributor.authorJonasson, Fridbert-
dc.date.accessioned2008-01-09T08:40:26Z-
dc.date.available2008-01-09T08:40:26Z-
dc.date.issued2005-08-01-
dc.date.submitted2007-01-09-
dc.identifier.citationArch. Ophthalmol. 2005, 123(8):1102-5en
dc.identifier.issn0003-9950-
dc.identifier.pmid16087845-
dc.identifier.doi10.1001/archopht.123.8.1102-
dc.identifier.urihttp://hdl.handle.net/2336/15852-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Aviation involves exposure to ionizing radiation of cosmic origin. The association between lesions of the ocular lens and ionizing radiation is well-known. OBJECTIVE: To investigate whether employment as a commercial airline pilot and the resulting exposure to cosmic radiation is associated with lens opacification. METHODS: This is a population-based case-control study of 445 men. Lens opacification was classified into 4 types using the World Health Organization simplified grading system. These 4 types, serving as cases, included 71 persons with nuclear cataracts, 102 with cortical lens opacification, 69 with central optical zone involvement, and 32 with posterior subcapsular lens opacification. Control subjects are those with a different type of lens opacification or without lens opacification. Exposure was assessed based on employment time as pilots, annual number of hours flown on each aircraft type, time tables, flight profiles, and individual cumulative radiation doses (in millisieverts) calculated by a software program. Odds ratios were calculated using logistic regression. RESULTS: The odds ratio for nuclear cataract risk among cases and controls was 3.02 (95% confidence interval, 1.44-6.35) for pilots compared with nonpilots, adjusted for age, smoking status, and sunbathing habits. The odds ratio for nuclear cataract associated with estimation of cumulative radiation dose (in millisieverts) to the age of 40 years was 1.06 (95% confidence interval, 1.02-1.10), adjusted for age, smoking status, and sunbathing habits. CONCLUSION: The association between the cosmic radiation exposure of pilots and the risk of nuclear cataracts, adjusted for age, smoking status, and sunbathing habits, indicates that cosmic radiation may be a causative factor in nuclear cataracts among commercial airline pilots.en
dc.language.isoenen
dc.publisherAmerican Medical Associationen
dc.relation.urlhttp://archopht.ama-assn.org/cgi/content/abstract/123/8/1102en
dc.subject.meshAerospace Medicineen
dc.subject.meshAgeden
dc.subject.meshAircraften
dc.subject.meshCase-Control Studiesen
dc.subject.meshCataracten
dc.subject.meshCosmic Radiationen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLens Nucleus, Crystallineen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOccupational Exposureen
dc.subject.meshOdds Ratioen
dc.subject.meshRadiation Dosageen
dc.subject.meshRadiation Injuriesen
dc.subject.meshRadiation, Ionizingen
dc.subject.meshRisk Factorsen
dc.titleCosmic radiation increases the risk of nuclear cataract in airline pilots: a population-based case-control study.en
dc.typeArticleen
dc.identifier.eissn1538-3601-
dc.contributor.departmentDepartment of Preventive Medicine, University of Iceland, Neshagi 16, 107 Reykjavik, Iceland. vilraf@hi.isen
dc.identifier.journalArchives of ophthalmologyen

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