Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland

2.50
Hdl Handle:
http://hdl.handle.net/2336/15854
Title:
Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland
Authors:
Halldórsdóttir, Anna Margrét; Sigurdardóttrir, Margrét; Jónasson, Jón Gunnlaugur; Oddsdóttir, Margrét; Magnússon, Jónas; Lee, Jeffrey R; Goldenring, James R
Citation:
Dig. Dis. Sci. 2003, 48(3):431-41
Issue Date:
1-Mar-2003
Abstract:
Recent studies have described a spasmolytic polypeptide-expressing metaplastic cell lineage (SPEM) in the gastric fundic mucosa associated with both chronic H. pylori infection and gastric adenocarcinoma. We investigated the association of SPEM both with early gastric adenocarcinoma and in biopsies taken from patients prior to diagnosis of cancer. Two cohorts were examined. First, gastric resections from 29 patients with early gastric cancer were examined. Second, biopsies taken from 18 patients prior to the diagnosis of gastric cancer were compared with their respective resection specimens as well as with control biopsies from a cohort of 19 patients diagnosed with gastritis without subsequent development of cancer. The presence of SPEM and intestinal metaplasia (IM) adjacent to and distant from the cancer was compared and spasmolytic polypeptide (SP) immunostaining within dysplastic/cancerous cells was identified. SPEM was present adjacent to cancer in all early cancer cases where the tumor was located in the body or at the body/antrum junction, and was present in the body mucosa distant from the cancer in 76% of cases. Intestinal metaplasia was found adjacent to the tumor in 76% of cases and in body sections in 52% of resections. SP immunostaining was noted within cancer cells in 62% of tumors, and within dysplastic cells in 76% of resections where dysplasia was present. SPEM was present in 82% of the biopsies obtained prior to the diagnosis of cancer, compared with only 37% in the gastritis cohort. IM was present in only 57% of biopsies. In conclusion, SPEM is strongly associated with early gastric cancers and is observed in gastric biopsies prior to the development of cancer. In addition, early gastric cancers demonstrated a high incidence of SP expression. These results suggest that SPEM merits consideration as an important pre-neoplastic gastric lesion.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.springerlink.com/content/q8u0550730hj3234

Full metadata record

DC FieldValue Language
dc.contributor.authorHalldórsdóttir, Anna Margrét-
dc.contributor.authorSigurdardóttrir, Margrét-
dc.contributor.authorJónasson, Jón Gunnlaugur-
dc.contributor.authorOddsdóttir, Margrét-
dc.contributor.authorMagnússon, Jónas-
dc.contributor.authorLee, Jeffrey R-
dc.contributor.authorGoldenring, James R-
dc.date.accessioned2008-01-09T09:43:27Z-
dc.date.available2008-01-09T09:43:27Z-
dc.date.issued2003-03-01-
dc.date.submitted2008-01-09-
dc.identifier.citationDig. Dis. Sci. 2003, 48(3):431-41en
dc.identifier.issn0163-2116-
dc.identifier.pmid12757153-
dc.identifier.doi10.1023/A:1022564027468-
dc.identifier.urihttp://hdl.handle.net/2336/15854-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractRecent studies have described a spasmolytic polypeptide-expressing metaplastic cell lineage (SPEM) in the gastric fundic mucosa associated with both chronic H. pylori infection and gastric adenocarcinoma. We investigated the association of SPEM both with early gastric adenocarcinoma and in biopsies taken from patients prior to diagnosis of cancer. Two cohorts were examined. First, gastric resections from 29 patients with early gastric cancer were examined. Second, biopsies taken from 18 patients prior to the diagnosis of gastric cancer were compared with their respective resection specimens as well as with control biopsies from a cohort of 19 patients diagnosed with gastritis without subsequent development of cancer. The presence of SPEM and intestinal metaplasia (IM) adjacent to and distant from the cancer was compared and spasmolytic polypeptide (SP) immunostaining within dysplastic/cancerous cells was identified. SPEM was present adjacent to cancer in all early cancer cases where the tumor was located in the body or at the body/antrum junction, and was present in the body mucosa distant from the cancer in 76% of cases. Intestinal metaplasia was found adjacent to the tumor in 76% of cases and in body sections in 52% of resections. SP immunostaining was noted within cancer cells in 62% of tumors, and within dysplastic cells in 76% of resections where dysplasia was present. SPEM was present in 82% of the biopsies obtained prior to the diagnosis of cancer, compared with only 37% in the gastritis cohort. IM was present in only 57% of biopsies. In conclusion, SPEM is strongly associated with early gastric cancers and is observed in gastric biopsies prior to the development of cancer. In addition, early gastric cancers demonstrated a high incidence of SP expression. These results suggest that SPEM merits consideration as an important pre-neoplastic gastric lesion.en
dc.language.isoenen
dc.publisherSpringer Science + Business Mediaen
dc.relation.urlhttp://www.springerlink.com/content/q8u0550730hj3234en
dc.subject.meshAdenocarcinomaen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAntibodies, Monoclonalen
dc.subject.meshCase-Control Studiesen
dc.subject.meshFemaleen
dc.subject.meshGastric Mucosaen
dc.subject.meshHelicobacter Infectionsen
dc.subject.meshHelicobacter pylorien
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshImmunohistochemistryen
dc.subject.meshMaleen
dc.subject.meshMetaplasiaen
dc.subject.meshMiddle Ageden
dc.subject.meshPeptidesen
dc.subject.meshPrecancerous Conditionsen
dc.subject.meshStomach Neoplasmsen
dc.titleSpasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Icelanden
dc.typeArticleen
dc.identifier.eissn1573-2568-
dc.contributor.departmentDepartment of Pathology, University Hospital of Iceland, Reykjavík.en
dc.identifier.journalDigestive diseases and sciencesen

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