2.50
Hdl Handle:
http://hdl.handle.net/2336/15866
Title:
Support for involvement of the AHI1 locus in schizophrenia
Authors:
Ingason, Andres; Sigmundsson, Thordur; Steinberg, Stacy; Sigurdsson, Engilbert; Haraldsson, Magnus; Magnusdottir, Brynja B; Frigge, Michael L; Kong, Augustine; Gulcher, Jeffrey; Thorsteinsdottir, Unnur; Stefansson, Kari; Petursson, Hannes; Stefansson, Hreinn
Citation:
Eur. J. Hum. Genet. 2007, 15(9):988-91
Issue Date:
1-Sep-2007
Abstract:
Recently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/sj.ejhg.5201848

Full metadata record

DC FieldValue Language
dc.contributor.authorIngason, Andres-
dc.contributor.authorSigmundsson, Thordur-
dc.contributor.authorSteinberg, Stacy-
dc.contributor.authorSigurdsson, Engilbert-
dc.contributor.authorHaraldsson, Magnus-
dc.contributor.authorMagnusdottir, Brynja B-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorGulcher, Jeffrey-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorPetursson, Hannes-
dc.contributor.authorStefansson, Hreinn-
dc.date.accessioned2008-01-09T13:30:46Z-
dc.date.available2008-01-09T13:30:46Z-
dc.date.issued2007-09-01-
dc.date.submitted2007-01-09-
dc.identifier.citationEur. J. Hum. Genet. 2007, 15(9):988-91en
dc.identifier.issn1018-4813-
dc.identifier.pmid17473831-
dc.identifier.doi10.1038/sj.ejhg.5201848-
dc.identifier.urihttp://hdl.handle.net/2336/15866-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractRecently, markers in the Abelson Helper Integration Site 1 (AHI1) region were shown to be associated with schizophrenia in a family sample of Israeli-Arabs. Here, we report a study evaluating the relevance of the AHI1 region to schizophrenia in an Icelandic sample. Seven markers shown to confer risk in the previous report were typed in 608 patients diagnosed with broad schizophrenia and 1,504 controls. Odds ratios for the overtransmitted alleles in the Israeli-Arab families ranged from 1.15 to 1.29 in the Icelandic sample. After Bonferroni correction for the seven markers tested, two markers were significantly associated with schizophrenia. Thus, our results are in general agreement with the previous report, with the strongest association signal observed in a region upstream of the AHI1 gene.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/sj.ejhg.5201848en
dc.subject.meshAdaptor Proteins, Signal Transducingen
dc.subject.meshCase-Control Studiesen
dc.subject.meshGenetic Markersen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshSchizophreniaen
dc.titleSupport for involvement of the AHI1 locus in schizophreniaen
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, Reykjavik, Iceland.en
dc.identifier.journalEuropean journal of human geneticsen

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