The effect of dietary fish oil on survival after infection with Klebsiella pneumoniae or Streptococcus pneumoniae.

2.50
Hdl Handle:
http://hdl.handle.net/2336/15914
Title:
The effect of dietary fish oil on survival after infection with Klebsiella pneumoniae or Streptococcus pneumoniae.
Authors:
Thors, Valtyr Stefansson; Thorisdottir, Audur; Erlendsdóttir, Helga; Einarsson, Ingolfur; Gudmundsson, Sigurdur; Gunnarsson, Eggert; Haraldsson, Asgeir
Citation:
Scand. J. Infect. Dis. 2004, 36(2):102-5
Issue Date:
1-Feb-2004
Abstract:
Dietary fish oil is believed to have a beneficial effect in various infections and in autoimmune disorders. This effect may correspond to an altered immune response. In order to discover whether the effect of dietary fish oil is different in various infections, we studied the survival of mice fed fish oil or corn oil supplemented diets and infected in the lungs with either Klebsiella pneumoniae or Streptococcus pneumoniae. 120 NMRI mice were divided into 4 groups, of which 2 groups were fed a fish oil supplemented diet and 2 a corn oil supplemented diet. After 6 weeks the mice were infected in the lungs with Klebsiella pneumoniae (fish oil groups and corn oil groups) or with Streptococcus pneumoniae serotype 3 (both groups). The survival rate was monitored. The experiment was performed twice. The survival of the mice fed fish oil enriched diet and infected with Klebsiella pneumoniae was significantly better compared with the mice fed corn oil enriched diet (p = 0.0001 and p = 0.0013). No difference was found between the mice fed corn oil enriched diet or fish oil enriched diet and infected with Streptococcus pneumoniae serotype 3 (p = 0.74 and p = 0.15). Our results indicate that dietary fish oil has a beneficial effect on survival of mice after experimental pneumoniae when infected with Klebsiella pneumoniae, but not after infection with Streptococcus pneumoniae serotype 3.
Description:
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Full metadata record

DC FieldValue Language
dc.contributor.authorThors, Valtyr Stefansson-
dc.contributor.authorThorisdottir, Audur-
dc.contributor.authorErlendsdóttir, Helga-
dc.contributor.authorEinarsson, Ingolfur-
dc.contributor.authorGudmundsson, Sigurdur-
dc.contributor.authorGunnarsson, Eggert-
dc.contributor.authorHaraldsson, Asgeir-
dc.date.accessioned2008-01-10T09:53:51Z-
dc.date.available2008-01-10T09:53:51Z-
dc.date.issued2004-02-01-
dc.date.submitted2007-01-10-
dc.identifier.citationScand. J. Infect. Dis. 2004, 36(2):102-5en
dc.identifier.issn0036-5548-
dc.identifier.pmid15061662-
dc.identifier.doi10.1080/00365540310018914-
dc.identifier.urihttp://hdl.handle.net/2336/15914-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractDietary fish oil is believed to have a beneficial effect in various infections and in autoimmune disorders. This effect may correspond to an altered immune response. In order to discover whether the effect of dietary fish oil is different in various infections, we studied the survival of mice fed fish oil or corn oil supplemented diets and infected in the lungs with either Klebsiella pneumoniae or Streptococcus pneumoniae. 120 NMRI mice were divided into 4 groups, of which 2 groups were fed a fish oil supplemented diet and 2 a corn oil supplemented diet. After 6 weeks the mice were infected in the lungs with Klebsiella pneumoniae (fish oil groups and corn oil groups) or with Streptococcus pneumoniae serotype 3 (both groups). The survival rate was monitored. The experiment was performed twice. The survival of the mice fed fish oil enriched diet and infected with Klebsiella pneumoniae was significantly better compared with the mice fed corn oil enriched diet (p = 0.0001 and p = 0.0013). No difference was found between the mice fed corn oil enriched diet or fish oil enriched diet and infected with Streptococcus pneumoniae serotype 3 (p = 0.74 and p = 0.15). Our results indicate that dietary fish oil has a beneficial effect on survival of mice after experimental pneumoniae when infected with Klebsiella pneumoniae, but not after infection with Streptococcus pneumoniae serotype 3.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12453943&site=ehost-liveen
dc.subject.meshAnimalsen
dc.subject.meshDietary Supplementsen
dc.subject.meshDisease Models, Animalen
dc.subject.meshFemaleen
dc.subject.meshFish Oilsen
dc.subject.meshKlebsiella Infectionsen
dc.subject.meshKlebsiella pneumoniaeen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred Strainsen
dc.subject.meshPneumococcal Infectionsen
dc.subject.meshProbabilityen
dc.subject.meshRandom Allocationen
dc.subject.meshReference Valuesen
dc.subject.meshRisk Assessmenten
dc.subject.meshSensitivity and Specificityen
dc.subject.meshStreptococcus pneumoniaeen
dc.subject.meshSurvival Analysisen
dc.titleThe effect of dietary fish oil on survival after infection with Klebsiella pneumoniae or Streptococcus pneumoniae.en
dc.typeArticleen
dc.identifier.journalScandinavian journal of infectious diseasesen

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