Oral biopsies from patients with orofacial granulomatosis with histology resembling Crohn's disease have a prominent Th1 environment.

2.50
Hdl Handle:
http://hdl.handle.net/2336/18352
Title:
Oral biopsies from patients with orofacial granulomatosis with histology resembling Crohn's disease have a prominent Th1 environment.
Authors:
Freysdottir, Jona; Zhang, Sha; Tilakaratne, Wanninayake M; Fortune, Farida
Citation:
Inflamm. Bowel Dis. 2007, 13(4):439-45
Issue Date:
1-Apr-2007
Abstract:
BACKGROUND: Orofacial granulomatosis (OFG) is an idiopathic inflammatory disorder of children and young adults whose clinical symptoms include swelling of the lips or face, mucosal nodularity (cobblestoning), mucosal tags, hyperplasia of the gingivae, and aphthous oral ulcers. Whether some OFG patients with clinical and histological characteristics resembling Crohn's disease (CD) are a special group (oral CD) or true CD patients with symptoms reaching all the way to the oral mucosa remains to be determined. METHODS: In this study oral biopsies from 10 patients with OFG were analyzed for the presence of T cells, T-cell subsets, B cells, and macrophages, as well as cytokines (IL-4, IL-10, IFN-gamma, IL-12, and TNF-alpha), chemokines (RANTES and MIP-1alpha), and chemokine receptors (CCR3, CCR5, and CXCR3). For comparison, oral tissues from 7 patients with other granulomatous diseases were included. RESULTS: Compared with the non-OFG group, the OFG group had raised levels of CD4(+) T cells, IFN-gamma, IL-10, and RANTES but reduced levels of CD68(+) macrophages outside the granulomas, whereas within the granulomas the levels of CD3(+) and CD4(+) T cells and of IFN-gamma were raised, but the levels of IL-4 were decreased. These data are indicative of a Th1 environment within the oral OFG tissues, which resembles that already observed in gut CD tissues. CONCLUSIONS: Therefore, it can be concluded that some OFG patients have both histopathological and immunopathological features that resemble those observed in CD patients.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1002/ibd.20023

Full metadata record

DC FieldValue Language
dc.contributor.authorFreysdottir, Jona-
dc.contributor.authorZhang, Sha-
dc.contributor.authorTilakaratne, Wanninayake M-
dc.contributor.authorFortune, Farida-
dc.date.accessioned2008-02-14T15:32:33Z-
dc.date.available2008-02-14T15:32:33Z-
dc.date.issued2007-04-01-
dc.date.submitted2007-12-01-
dc.identifier.citationInflamm. Bowel Dis. 2007, 13(4):439-45en
dc.identifier.issn1078-0998-
dc.identifier.pmid17206709-
dc.identifier.doi10.1002/ibd.20023-
dc.identifier.urihttp://hdl.handle.net/2336/18352-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Orofacial granulomatosis (OFG) is an idiopathic inflammatory disorder of children and young adults whose clinical symptoms include swelling of the lips or face, mucosal nodularity (cobblestoning), mucosal tags, hyperplasia of the gingivae, and aphthous oral ulcers. Whether some OFG patients with clinical and histological characteristics resembling Crohn's disease (CD) are a special group (oral CD) or true CD patients with symptoms reaching all the way to the oral mucosa remains to be determined. METHODS: In this study oral biopsies from 10 patients with OFG were analyzed for the presence of T cells, T-cell subsets, B cells, and macrophages, as well as cytokines (IL-4, IL-10, IFN-gamma, IL-12, and TNF-alpha), chemokines (RANTES and MIP-1alpha), and chemokine receptors (CCR3, CCR5, and CXCR3). For comparison, oral tissues from 7 patients with other granulomatous diseases were included. RESULTS: Compared with the non-OFG group, the OFG group had raised levels of CD4(+) T cells, IFN-gamma, IL-10, and RANTES but reduced levels of CD68(+) macrophages outside the granulomas, whereas within the granulomas the levels of CD3(+) and CD4(+) T cells and of IFN-gamma were raised, but the levels of IL-4 were decreased. These data are indicative of a Th1 environment within the oral OFG tissues, which resembles that already observed in gut CD tissues. CONCLUSIONS: Therefore, it can be concluded that some OFG patients have both histopathological and immunopathological features that resemble those observed in CD patients.en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Incen
dc.relation.urlhttp://dx.doi.org/10.1002/ibd.20023en
dc.subject.meshCase-Control Studiesen
dc.subject.meshChemokinesen
dc.subject.meshCrohn Diseaseen
dc.subject.meshCytokinesen
dc.subject.meshGranulomatosis, Orofacialen
dc.subject.meshHumansen
dc.subject.meshImmunohistochemistryen
dc.subject.meshReceptors, Chemokineen
dc.subject.meshTh1 Cellsen
dc.titleOral biopsies from patients with orofacial granulomatosis with histology resembling Crohn's disease have a prominent Th1 environment.en
dc.typeArticleen
dc.identifier.eissn1536-4844-
dc.contributor.departmentDepartment of Oral Medicine, Leeds Dental Institute, Leeds, United Kingdom.en
dc.identifier.journalInflammatory bowel diseasesen

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