Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/2336/18698
Title:
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
Authors:
Grant, Struan F A; Thorleifsson, Gudmar; Reynisdottir, Inga; Benediktsson, Rafn; Manolescu, Andrei; Sainz, Jesus; Helgason, Agnar; Stefansson, Hreinn; Emilsson, Valur; Helgadottir, Anna; Styrkarsdottir, Unnur; Magnusson, Kristinn P; Walters, G Bragi; Palsdottir, Ebba; Jonsdottir, Thorbjorg; Gudmundsdottir, Thorunn; Gylfason, Arnaldur; Saemundsdottir, Jona; Wilensky, Robert L; Reilly, Muredach P; Rader, Daniel J; Bagger, Yu; Christiansen, Claus; Gudnason, Vilmundur; Sigurdsson, Gunnar; Thorsteinsdottir, Unnur; Gulcher, Jeffrey R; Kong, Augustine; Stefansson, Kari
Citation:
Nat. Genet. 2006, 38(3):320-3
Issue Date:
1-Mar-2006
Abstract:
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 x 10(-9)). This was replicated in a Danish cohort (P = 4.8 x 10(-3)) and in a US cohort (P = 3.3 x 10(-9)). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The TCF7L2 gene product is a high mobility group box-containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng1732

Full metadata record

DC FieldValue Language
dc.contributor.authorGrant, Struan F A-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorReynisdottir, Inga-
dc.contributor.authorBenediktsson, Rafn-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorSainz, Jesus-
dc.contributor.authorHelgason, Agnar-
dc.contributor.authorStefansson, Hreinn-
dc.contributor.authorEmilsson, Valur-
dc.contributor.authorHelgadottir, Anna-
dc.contributor.authorStyrkarsdottir, Unnur-
dc.contributor.authorMagnusson, Kristinn P-
dc.contributor.authorWalters, G Bragi-
dc.contributor.authorPalsdottir, Ebba-
dc.contributor.authorJonsdottir, Thorbjorg-
dc.contributor.authorGudmundsdottir, Thorunn-
dc.contributor.authorGylfason, Arnaldur-
dc.contributor.authorSaemundsdottir, Jona-
dc.contributor.authorWilensky, Robert L-
dc.contributor.authorReilly, Muredach P-
dc.contributor.authorRader, Daniel J-
dc.contributor.authorBagger, Yu-
dc.contributor.authorChristiansen, Claus-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorSigurdsson, Gunnar-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-02-20T11:14:06Z-
dc.date.available2008-02-20T11:14:06Z-
dc.date.issued2006-03-01-
dc.identifier.citationNat. Genet. 2006, 38(3):320-3en
dc.identifier.issn1061-4036-
dc.identifier.pmid16415884-
dc.identifier.doi10.1038/ng1732-
dc.identifier.urihttp://hdl.handle.net/2336/18698-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes (P = 2.1 x 10(-9)). This was replicated in a Danish cohort (P = 4.8 x 10(-3)) and in a US cohort (P = 3.3 x 10(-9)). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The TCF7L2 gene product is a high mobility group box-containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng1732en
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 10en
dc.subject.meshCohort Studiesen
dc.subject.meshDenmarken
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshGene Frequencyen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHeterozygote Detectionen
dc.subject.meshHumansen
dc.subject.meshIntronsen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshReference Valuesen
dc.subject.meshTCF Transcription Factorsen
dc.titleVariant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.en
dc.typeArticleen
dc.identifier.eissn1546-1718-
dc.contributor.departmentdeCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland. struan.grant@decode.isen
dc.identifier.journalNature geneticsen

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