The role of atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies in Childhood Phase Two

2.50
Hdl Handle:
http://hdl.handle.net/2336/19118
Title:
The role of atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies in Childhood Phase Two
Authors:
Flohr, Carsten; Weiland, Stephan K; Weinmayr, Gudrun; Björkstén, Bengt; Bråbäck, Lennart; Brunekreef, Bert; Büchele, Gisela; Clausen, Michael; Cookson, William O C; von Mutius, Erika; Strachan, David P; Williams, Hywel C
Citation:
J. Allergy Clin. Immunol. 2008, 121(1):141-147.e4
Issue Date:
1-Jan-2008
Abstract:
BACKGROUND: The association between allergic sensitization and eczema has been debated for years. OBJECTIVE: We sought to determine and compare the strength of the association between allergen skin sensitization and eczema in both developing and industrialized countries. METHODS: Twenty-eight thousand five hundred ninety-one randomly selected 8- to 12-year-old schoolchildren in 20 countries were physically examined for flexural eczema and received skin prick testing to Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat hair, Alternaria tenuis, mixed tree and grass pollen, and allergens of local relevance. RESULTS: The age- and sex-adjusted odds ratios (ORs) for a positive association between flexural eczema and atopy ranged between 0.74 (95% CI, 0.31-1.81) and 4.53 (95% CI, 1.72-11.93), with a significantly stronger association in affluent compared with nonaffluent countries (combined age- and sex-adjusted OR(affluent) = 2.69 [95% CI, 2.31-3.13] and OR(nonaffluent) = 1.17 [95% CI, 0.81-1.70]). The combined population attributable fraction for atopy in flexural eczema was 27.9% for affluent and 1.2% for nonaffluent-country centers. Correlating gross national per-capita income with either ORs or population attributable fractions for atopy in flexural eczema confirmed a highly significant positive association (P = .006 and P < .001, respectively). CONCLUSIONS: The association between atopy and flexural eczema is weak and more variable than previously suggested, and the strength of this association is positively linked to gross national income.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WH4-4R2GRV6-7/2/5bf7b0dcbcf5e957d58cd93a94e92171

Full metadata record

DC FieldValue Language
dc.contributor.authorFlohr, Carsten-
dc.contributor.authorWeiland, Stephan K-
dc.contributor.authorWeinmayr, Gudrun-
dc.contributor.authorBjörkstén, Bengt-
dc.contributor.authorBråbäck, Lennart-
dc.contributor.authorBrunekreef, Bert-
dc.contributor.authorBüchele, Gisela-
dc.contributor.authorClausen, Michael-
dc.contributor.authorCookson, William O C-
dc.contributor.authorvon Mutius, Erika-
dc.contributor.authorStrachan, David P-
dc.contributor.authorWilliams, Hywel C-
dc.date.accessioned2008-02-25T13:27:52Z-
dc.date.available2008-02-25T13:27:52Z-
dc.date.issued2008-01-01-
dc.date.submitted2008-02-25-
dc.identifier.citationJ. Allergy Clin. Immunol. 2008, 121(1):141-147.e4en
dc.identifier.issn1097-6825-
dc.identifier.pmid17980410-
dc.identifier.doi10.1016/j.jaci.2007.08.066-
dc.identifier.urihttp://hdl.handle.net/2336/19118-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The association between allergic sensitization and eczema has been debated for years. OBJECTIVE: We sought to determine and compare the strength of the association between allergen skin sensitization and eczema in both developing and industrialized countries. METHODS: Twenty-eight thousand five hundred ninety-one randomly selected 8- to 12-year-old schoolchildren in 20 countries were physically examined for flexural eczema and received skin prick testing to Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat hair, Alternaria tenuis, mixed tree and grass pollen, and allergens of local relevance. RESULTS: The age- and sex-adjusted odds ratios (ORs) for a positive association between flexural eczema and atopy ranged between 0.74 (95% CI, 0.31-1.81) and 4.53 (95% CI, 1.72-11.93), with a significantly stronger association in affluent compared with nonaffluent countries (combined age- and sex-adjusted OR(affluent) = 2.69 [95% CI, 2.31-3.13] and OR(nonaffluent) = 1.17 [95% CI, 0.81-1.70]). The combined population attributable fraction for atopy in flexural eczema was 27.9% for affluent and 1.2% for nonaffluent-country centers. Correlating gross national per-capita income with either ORs or population attributable fractions for atopy in flexural eczema confirmed a highly significant positive association (P = .006 and P < .001, respectively). CONCLUSIONS: The association between atopy and flexural eczema is weak and more variable than previously suggested, and the strength of this association is positively linked to gross national income.en
dc.language.isoenen
dc.publisherMosbyen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WH4-4R2GRV6-7/2/5bf7b0dcbcf5e957d58cd93a94e92171en
dc.subject.meshPubMed - in processen
dc.titleThe role of atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies in Childhood Phase Twoen
dc.typeArticleen
dc.contributor.departmentCentre of Evidence Based Dermatology and the Centre for Population Sciences, Institute of Clinical Research, University of Nottingham, Nottingham, United Kingdom. carsten.flohr@nottingham.ac.uken
dc.identifier.journalJournal of allergy and clinical immunologyen

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