A synergic effect between lowered serotonin and novel situations on impulsivity measured by CPT.

2.50
Hdl Handle:
http://hdl.handle.net/2336/20092
Title:
A synergic effect between lowered serotonin and novel situations on impulsivity measured by CPT.
Authors:
Walderhaug, E; Landrø, NI; Magnusson, A
Citation:
J Clin Exp Neuropsychol. 2008, 30(2):204-211
Issue Date:
1-Feb-2008
Abstract:
Rapid tryptophan depletion studies investigate serotonin using amino acid precursor depletion, which transiently reduces the brain level of serotonin. This study compares the effects of serotonin reduction given on the first test day (when the situation is novel) with the effects of serotonin reduction given on the second test day (when the environment and test battery are familiar). A total of 24 healthy young males were given either active tryptophan depletion or placebo in this randomized cross-over design, while impulsivity was measured by a continuous performance test. The participants showed more impulsive responses and reduced attention during tryptophan depletion, but only when this was given on the first test day when the task was novel. This could be caused by a synergic effect between novel situations and reduced neurotransmission of serotonin.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://www.informaworld.com/10.1080/13803390701346311

Full metadata record

DC FieldValue Language
dc.contributor.authorWalderhaug, E-
dc.contributor.authorLandrø, NI-
dc.contributor.authorMagnusson, A-
dc.date.accessioned2008-03-07T13:04:56Z-
dc.date.available2008-03-07T13:04:56Z-
dc.date.issued2008-02-01-
dc.date.submitted2008-03-07-
dc.identifier.citationJ Clin Exp Neuropsychol. 2008, 30(2):204-211en
dc.identifier.issn1380-3395-
dc.identifier.pmid17852573-
dc.identifier.doi10.1080/13803390701346311-
dc.identifier.urihttp://hdl.handle.net/2336/20092-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractRapid tryptophan depletion studies investigate serotonin using amino acid precursor depletion, which transiently reduces the brain level of serotonin. This study compares the effects of serotonin reduction given on the first test day (when the situation is novel) with the effects of serotonin reduction given on the second test day (when the environment and test battery are familiar). A total of 24 healthy young males were given either active tryptophan depletion or placebo in this randomized cross-over design, while impulsivity was measured by a continuous performance test. The participants showed more impulsive responses and reduced attention during tryptophan depletion, but only when this was given on the first test day when the task was novel. This could be caused by a synergic effect between novel situations and reduced neurotransmission of serotonin.en
dc.languageENG-
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.informaworld.com/10.1080/13803390701346311en
dc.titleA synergic effect between lowered serotonin and novel situations on impulsivity measured by CPT.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, National University Hospital, Reykjavik, Icelanden
dc.identifier.journalJournal of clinical and experimental neuropsychologyen
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