Positive association between plasma antioxidant capacity and n-3 PUFA in red blood cells from women.

2.50
Hdl Handle:
http://hdl.handle.net/2336/20857
Title:
Positive association between plasma antioxidant capacity and n-3 PUFA in red blood cells from women.
Authors:
Thorlaksdottir, A Y; Skuladottir, G V; Petursdottir, A L; Tryggvadottir, L; Ogmundsdottir, H M; Eyfjord, J E; Jonsson, J J; Hardardottir, I
Citation:
Lipids 2006, 41 (2):119-25
Issue Date:
1-Feb-2006
Abstract:
PUFA are susceptible to oxidation. However, the chain-reaction of lipid peroxidation can be interrupted by antioxidants. Whether an increased concentration of PUFA in the body leads to decreased antioxidant capacity and/or increased consumption of antioxidants is not known. To elucidate the relationship between plasma total antioxidant capacity (TAC), the concentration of antioxidant vitamins, and the proportion of PUFA in red blood cells (RBC), plasma TAC was measured by a Trolox equivalent antioxidant capacity assay in blood samples from 99 Icelandic women. Concentrations of tocopherols and carotenoids in the plasma were determined by HPLC, and the FA composition of RBC total lipids was analyzed by GC. Plasma TAC and the plasma concentration of alpha-tocopherol correlated positively with the proportion of total n-3 PUFA, 20:5n-3, and 22:6n-3 in RBC, whereas the plasma lycopene concentration correlated negatively with the proportion of total n-3 PUFA and 20:5n-3. On the other hand, plasma TAC correlated negatively with the proportion of n-6 PUFA in RBC. Plasma TAC also correlated positively with the plasma concentration of alpha-tocopherol, alcohol consumption, and age. Both the plasma concentration of alpha-tocopherol and age correlated positively with the proportion of n-3 PUFA in RBC; however, n-3 PUFA contributed independently to the correlation with plasma TAC. Because the proportion of n-3 PUFA in RBC reflects the consumption of n-3 PUFA, these results suggest that dietary n-3 PUFA do not have adverse effects on plasma TAC or the plasma concentration of most antioxidant vitamins.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
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Full metadata record

DC FieldValue Language
dc.contributor.authorThorlaksdottir, A Y-
dc.contributor.authorSkuladottir, G V-
dc.contributor.authorPetursdottir, A L-
dc.contributor.authorTryggvadottir, L-
dc.contributor.authorOgmundsdottir, H M-
dc.contributor.authorEyfjord, J E-
dc.contributor.authorJonsson, J J-
dc.contributor.authorHardardottir, I-
dc.date.accessioned2008-03-17T14:21:41Z-
dc.date.available2008-03-17T14:21:41Z-
dc.date.issued2006-02-01-
dc.date.submitted2008-03-17-
dc.identifier.citationLipids 2006, 41 (2):119-25en
dc.identifier.issn0024-4201-
dc.identifier.pmid17707977-
dc.identifier.urihttp://hdl.handle.net/2336/20857-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPUFA are susceptible to oxidation. However, the chain-reaction of lipid peroxidation can be interrupted by antioxidants. Whether an increased concentration of PUFA in the body leads to decreased antioxidant capacity and/or increased consumption of antioxidants is not known. To elucidate the relationship between plasma total antioxidant capacity (TAC), the concentration of antioxidant vitamins, and the proportion of PUFA in red blood cells (RBC), plasma TAC was measured by a Trolox equivalent antioxidant capacity assay in blood samples from 99 Icelandic women. Concentrations of tocopherols and carotenoids in the plasma were determined by HPLC, and the FA composition of RBC total lipids was analyzed by GC. Plasma TAC and the plasma concentration of alpha-tocopherol correlated positively with the proportion of total n-3 PUFA, 20:5n-3, and 22:6n-3 in RBC, whereas the plasma lycopene concentration correlated negatively with the proportion of total n-3 PUFA and 20:5n-3. On the other hand, plasma TAC correlated negatively with the proportion of n-6 PUFA in RBC. Plasma TAC also correlated positively with the plasma concentration of alpha-tocopherol, alcohol consumption, and age. Both the plasma concentration of alpha-tocopherol and age correlated positively with the proportion of n-3 PUFA in RBC; however, n-3 PUFA contributed independently to the correlation with plasma TAC. Because the proportion of n-3 PUFA in RBC reflects the consumption of n-3 PUFA, these results suggest that dietary n-3 PUFA do not have adverse effects on plasma TAC or the plasma concentration of most antioxidant vitamins.en
dc.language.isoenen
dc.publisherAmerican Oil Chemists Societyen
dc.relation.urlhttp://proquest.umi.com/pqdweb?did=1019629211&sid=3&Fmt=2&clientId=58120&RQT=309&VName=PQDen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAntioxidantsen
dc.subject.meshErythrocytesen
dc.subject.meshFatty Acids, Omega-3en
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMiddle Ageden
dc.titlePositive association between plasma antioxidant capacity and n-3 PUFA in red blood cells from women.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.en
dc.identifier.journalLipidsen

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