2.50
Hdl Handle:
http://hdl.handle.net/2336/21052
Title:
Maturation of mucosal immune responses and influence of maternal antibodies
Authors:
Jonsdottir, I
Citation:
J. Comp. Pathol. 2007, 137 Suppl 1:S20-6
Issue Date:
1-Jul-2007
Abstract:
The mucosae represent the primary point of contact between the major respiratory and enteric pathogens and the innate and adaptive immune response. The microanatomy and function of the mucosal immune system is now well-characterized, in particular the major effector mechanism that involves the production and translocation of secretory immunoglobulin A (IgA). Mucosal delivery of antigen has the potential to induce potent local and systemic immunity, although such responses may differ between neonatal, infant and adult mice. In younger animals mucosal immune responses are Th2 biased, whereas in adults there is a broader Th1 and Th2 responsiveness. There is much interest in the development of mucosally delivered vaccines which can be tailored to enhance Th1 immunity or to avoid potential interference from maternally derived antibodies (MDA). Accordingly, a range of mucosal adjuvants (particularly those derived from bacteria) has been tested, and live recombinant vectored vaccines may also be effectively delivered by this route.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WHW-4NX8RN7-1/2/14179706d79a7a6ecfce6e9115a6f408

Full metadata record

DC FieldValue Language
dc.contributor.authorJonsdottir, I-
dc.date.accessioned2008-03-18T15:00:59Z-
dc.date.available2008-03-18T15:00:59Z-
dc.date.issued2007-07-01-
dc.date.submitted2008-03-18-
dc.identifier.citationJ. Comp. Pathol. 2007, 137 Suppl 1:S20-6en
dc.identifier.issn0021-9975-
dc.identifier.pmid17559864-
dc.identifier.doi10.1016/j.jcpa.2007.04.007-
dc.identifier.urihttp://hdl.handle.net/2336/21052-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe mucosae represent the primary point of contact between the major respiratory and enteric pathogens and the innate and adaptive immune response. The microanatomy and function of the mucosal immune system is now well-characterized, in particular the major effector mechanism that involves the production and translocation of secretory immunoglobulin A (IgA). Mucosal delivery of antigen has the potential to induce potent local and systemic immunity, although such responses may differ between neonatal, infant and adult mice. In younger animals mucosal immune responses are Th2 biased, whereas in adults there is a broader Th1 and Th2 responsiveness. There is much interest in the development of mucosally delivered vaccines which can be tailored to enhance Th1 immunity or to avoid potential interference from maternally derived antibodies (MDA). Accordingly, a range of mucosal adjuvants (particularly those derived from bacteria) has been tested, and live recombinant vectored vaccines may also be effectively delivered by this route.en
dc.language.isoenen
dc.publisherAcademic Pressen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WHW-4NX8RN7-1/2/14179706d79a7a6ecfce6e9115a6f408en
dc.subject.meshAdjuvants, Immunologicen
dc.subject.meshAdministration, Intranasalen
dc.subject.meshAnimalsen
dc.subject.meshAnimals, Newbornen
dc.subject.meshAntibody Formationen
dc.subject.meshHumansen
dc.subject.meshImmune Systemen
dc.subject.meshImmunity, Maternally-Acquireden
dc.subject.meshImmunity, Mucosalen
dc.subject.meshInfant, Newbornen
dc.subject.meshMiceen
dc.subject.meshVaccinationen
dc.titleMaturation of mucosal immune responses and influence of maternal antibodiesen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Landspitali University Hospital, University of Iceland and de CODE genetics, Hringbraut, 101 Reykjavík, Iceland. ingileif@landspitalis.isen
dc.identifier.journalJournal of comparative pathologyen

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