Scopolamine for prevention of postoperative nausea in gynecologic laparoscopy, a randomized trial

2.50
Hdl Handle:
http://hdl.handle.net/2336/21175
Title:
Scopolamine for prevention of postoperative nausea in gynecologic laparoscopy, a randomized trial
Authors:
Einarsson, Jon I; Audbergsson, Bjarki O; Thorsteinsson, Adalbjorn
Citation:
J Minim Invasive Gynecol 15 (1):26-31
Issue Date:
1-Jan-2008
Abstract:
STUDY OBJECTIVE: We sought to estimate effectiveness of transdermal scopolamine to prevent postoperative nausea and vomiting after gynecologic laparoscopy. DESIGN: Patients were randomized to receive preoperative transdermal scopolamine or placebo. Main outcome measure was incidence of nausea during the first 24 hours postoperatively. Wilcoxon rank sum, Student t, chi(2), and Fischer exact tests were used for data analysis (Canadian Task Force classification IA). SETTING: Academic teaching hospital. PATIENTS: A total of 48 patients undergoing gynecologic laparoscopy were studied. INTERVENTIONS: Randomized administration of transdermal Scopolamine or placebo in patients having gynecologic laparoscopic surgery. MEASUREMENTS AND MAIN RESULTS: Patients in the scopolamine group had significantly less incidence of nausea (20.8% vs 62.5%, p = .003) and vomiting (8.3% vs 37.5%, p = .016) during the first 24 hours after surgery. Number needed to treat was 3 (95% CI 1.5, 6.1) for nausea and 4 (95% CI 1.9, 14.6) for vomiting. Symptoms of visual disturbance and dry mouth were more common in the scopolamine group. CONCLUSION: Scopolamine patch significantly reduces incidence and severity of nausea and vomiting in the first 24 hours after gynecologic laparoscopic surgery.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B7MDF-4RSJ552-F/2/e76201c581d45c2ed9dce36d360e4a42

Full metadata record

DC FieldValue Language
dc.contributor.authorEinarsson, Jon I-
dc.contributor.authorAudbergsson, Bjarki O-
dc.contributor.authorThorsteinsson, Adalbjorn-
dc.date.accessioned2008-03-19T14:35:06Z-
dc.date.available2008-03-19T14:35:06Z-
dc.date.issued2008-01-01-
dc.date.submitted2008-03-19-
dc.identifier.citationJ Minim Invasive Gynecol 15 (1):26-31en
dc.identifier.issn1553-4650-
dc.identifier.pmid18262140-
dc.identifier.doi10.1016/j.jmig.2007.08.616-
dc.identifier.urihttp://hdl.handle.net/2336/21175-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSTUDY OBJECTIVE: We sought to estimate effectiveness of transdermal scopolamine to prevent postoperative nausea and vomiting after gynecologic laparoscopy. DESIGN: Patients were randomized to receive preoperative transdermal scopolamine or placebo. Main outcome measure was incidence of nausea during the first 24 hours postoperatively. Wilcoxon rank sum, Student t, chi(2), and Fischer exact tests were used for data analysis (Canadian Task Force classification IA). SETTING: Academic teaching hospital. PATIENTS: A total of 48 patients undergoing gynecologic laparoscopy were studied. INTERVENTIONS: Randomized administration of transdermal Scopolamine or placebo in patients having gynecologic laparoscopic surgery. MEASUREMENTS AND MAIN RESULTS: Patients in the scopolamine group had significantly less incidence of nausea (20.8% vs 62.5%, p = .003) and vomiting (8.3% vs 37.5%, p = .016) during the first 24 hours after surgery. Number needed to treat was 3 (95% CI 1.5, 6.1) for nausea and 4 (95% CI 1.9, 14.6) for vomiting. Symptoms of visual disturbance and dry mouth were more common in the scopolamine group. CONCLUSION: Scopolamine patch significantly reduces incidence and severity of nausea and vomiting in the first 24 hours after gynecologic laparoscopic surgery.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/B7MDF-4RSJ552-F/2/e76201c581d45c2ed9dce36d360e4a42en
dc.subject.meshPubMed - in processen
dc.titleScopolamine for prevention of postoperative nausea in gynecologic laparoscopy, a randomized trialen
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Landspitali-University Hospital, Reykjavik, Iceland.en
dc.identifier.journalJournal of minimally invasive gynecologyen
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