Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study.

2.50
Hdl Handle:
http://hdl.handle.net/2336/21450
Title:
Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study.
Authors:
van Straaten, Elisabeth C W; Scheltens, Philip; Knol, Dirk L; van Buchem, Mark A; van Dijk, Ewout J; Hofman, Paul A M; Karas, Giorgos; Kjartansson, Olafur; de Leeuw, Frank-Erik; Prins, Niels D; Schmidt, Reinhold; Visser, Marieke C; Weinstein, Henry C; Barkhof, Frederik
Citation:
Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study. 2003, 34 (8):1907-12 Stroke
Issue Date:
1-Aug-2003
Abstract:
BACKGROUND AND PURPOSE: Vascular dementia (VaD) is thought to be the most common cause of dementia after Alzheimer's disease. The commonly used International Workshop of the National Institute of Neurological Disorders and Stroke (NINDS) and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (AIREN) criteria for VaD necessitate evidence of vascular disease on CT or MRI of the brain. The purposes of our study were to operationalize the radiological part of the NINDS-AIREN criteria and to assess the effect of this operationalization on interobserver agreement. METHODS: Six experienced and 4 inexperienced observers rated a set of 40 MRI studies of patients with clinically suspected VaD twice using the NINDS-AIREN set of radiological criteria. After the first reading session, operational definitions were conceived, which were subsequently used in the second reading session. Interobserver reproducibility was measured by Cohen's kappa. RESULTS: Overall agreement at the first reading session was poor (kappa=0.29) and improved slightly after application of the additional definitions (kappa=0.38). Raters in the experienced group improved their agreement from almost moderate (kappa=0.39) to good (0.62). The inexperienced group started out with poor agreement (kappa=0.17) and did not improve (kappa=0.18). The experienced group improved in both the large- and small-vessel categories, whereas the inexperienced group improved generally in the extensive white matter hyperintensities categories. CONCLUSIONS: Considerable interobserver variability exists for the assessment of the radiological part of the NINDS-AIREN criteria. Use of operational definitions improves agreement but only for already experienced observers.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://stroke.ahajournals.org/cgi/content/abstract/34/8/1907

Full metadata record

DC FieldValue Language
dc.contributor.authorvan Straaten, Elisabeth C W-
dc.contributor.authorScheltens, Philip-
dc.contributor.authorKnol, Dirk L-
dc.contributor.authorvan Buchem, Mark A-
dc.contributor.authorvan Dijk, Ewout J-
dc.contributor.authorHofman, Paul A M-
dc.contributor.authorKaras, Giorgos-
dc.contributor.authorKjartansson, Olafur-
dc.contributor.authorde Leeuw, Frank-Erik-
dc.contributor.authorPrins, Niels D-
dc.contributor.authorSchmidt, Reinhold-
dc.contributor.authorVisser, Marieke C-
dc.contributor.authorWeinstein, Henry C-
dc.contributor.authorBarkhof, Frederik-
dc.date.accessioned2008-03-25T15:14:57Z-
dc.date.available2008-03-25T15:14:57Z-
dc.date.issued2003-08-01-
dc.date.submitted2008-03-25-
dc.identifier.citationOperational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study. 2003, 34 (8):1907-12 Strokeen
dc.identifier.issn0039-2499-
dc.identifier.pmid12855825-
dc.identifier.doi10.1161/01.STR.0000083050.44441.10-
dc.identifier.urihttp://hdl.handle.net/2336/21450-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND AND PURPOSE: Vascular dementia (VaD) is thought to be the most common cause of dementia after Alzheimer's disease. The commonly used International Workshop of the National Institute of Neurological Disorders and Stroke (NINDS) and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (AIREN) criteria for VaD necessitate evidence of vascular disease on CT or MRI of the brain. The purposes of our study were to operationalize the radiological part of the NINDS-AIREN criteria and to assess the effect of this operationalization on interobserver agreement. METHODS: Six experienced and 4 inexperienced observers rated a set of 40 MRI studies of patients with clinically suspected VaD twice using the NINDS-AIREN set of radiological criteria. After the first reading session, operational definitions were conceived, which were subsequently used in the second reading session. Interobserver reproducibility was measured by Cohen's kappa. RESULTS: Overall agreement at the first reading session was poor (kappa=0.29) and improved slightly after application of the additional definitions (kappa=0.38). Raters in the experienced group improved their agreement from almost moderate (kappa=0.39) to good (0.62). The inexperienced group started out with poor agreement (kappa=0.17) and did not improve (kappa=0.18). The experienced group improved in both the large- and small-vessel categories, whereas the inexperienced group improved generally in the extensive white matter hyperintensities categories. CONCLUSIONS: Considerable interobserver variability exists for the assessment of the radiological part of the NINDS-AIREN criteria. Use of operational definitions improves agreement but only for already experienced observers.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://stroke.ahajournals.org/cgi/content/abstract/34/8/1907en
dc.subject.meshBrainen
dc.subject.meshDementia, Vascularen
dc.subject.meshHumansen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshNetherlandsen
dc.subject.meshObserver Variationen
dc.subject.meshReproducibility of Resultsen
dc.titleOperational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study.en
dc.typeArticleen
dc.identifier.eissn1524-4628-
dc.contributor.departmentDepartment of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, Netherlands. i.vanstraaten@vumc.nlen
dc.identifier.journalStroke; a journal of cerebral circulationen

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