Relationships between vitamin D status and cardio-metabolic risk factors in young European adults.

2.50
Hdl Handle:
http://hdl.handle.net/2336/227536
Title:
Relationships between vitamin D status and cardio-metabolic risk factors in young European adults.
Authors:
Muldowney, S; Lucey, A J; Paschos, G; Martinez, J A; Bandarra, N; Thorsdottir, I; Cashman, K D; Kiely, M
Citation:
Ann. Nutr. Metab. 2011, 58(2):85-93
Issue Date:
2011
Abstract:
BACKGROUND/AIMS: To explore associations between vitamin D and cardiovascular disease risk factors in young European adults. METHODS: This was a cross-sectional analysis of serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone (iPTH) and biomarkers of cardiovascular disease risk in 195 healthy 20- to 40-year-olds (109 women) with a BMI between 27.5 and 32.5 from Iceland (64° N; n = 82), Ireland (51° N; n = 37) and Spain (42° N; n = 76) during mid-late winter. RESULTS: The median s25(OH)D was 52.8 nmol/l (IQR 38.1-69.9) or 21.1 ng/ml (IQR 15.2-28.0) with a latitude-dependent gradient (p ≤ 0.0001): Iceland, 41.7 nmol/l (IQR 32.7-54.2) or 16.7 ng/ml (IQR 13.1-21.7); Ireland, 52.9 nmol/l (IQR 35.3-68.6) or 21.2 ng/ml (IQR 14.1-27.4), and Spain, 67.1 nmol/l (IQR 47.1-87.1) or 26.8 ng/ml (IQR 18.8-34.8). Eleven percent of Icelandic participants had s25(OH)D concentrations <25 nmol/l (10 ng/ml) and 66% of Icelandic, 43% of Irish, and 30% of Spanish volunteers had concentrations <50 nmol/l (20 ng/ml), respectively. Overall, 17% met 3 or more of the NCEP/ATP III criteria for cardio-metabolic syndrome (MetS). Participants in the lowest third of s25(OH)D [≤ 42.5 nmol/l (17 ng/ml)] were more likely to have MetS (OR 2.49, p = 0.045) and elevated TAG (OR 3.46, p = 0.019). Individuals with iPTH concentrations in the lowest third [2.34 pmol/l (22.2 pg/ml)] were more likely to have elevated fasting TAG (OR 4.17, p = 0.039), insulin (OR 3.15, p = 0.029) and HOMA-IR (OR 2.15, p = 0.031), and they were less likely to have elevated IL-6 (OR 0.24, p = 0.003). CONCLUSION: There were interactions between s25(OH)D, iPTH and cardio-metabolic risk factors which, given the increasing prevalence of overweight and obesity and a low vitamin D status among adults, require randomised controlled vitamin D intervention studies in overweight persons.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links:
http://dx.doi.org/10.1159/000324600
Rights:
Archived with thanks to Annals of nutrition & metabolism

Full metadata record

DC FieldValue Language
dc.contributor.authorMuldowney, Sen_GB
dc.contributor.authorLucey, A Jen_GB
dc.contributor.authorPaschos, Gen_GB
dc.contributor.authorMartinez, J Aen_GB
dc.contributor.authorBandarra, Nen_GB
dc.contributor.authorThorsdottir, Ien_GB
dc.contributor.authorCashman, K Den_GB
dc.contributor.authorKiely, Men_GB
dc.date.accessioned2012-06-05T11:09:16Z-
dc.date.available2012-06-05T11:09:16Z-
dc.date.issued2011-
dc.date.submitted2012-06-05-
dc.identifier.citationAnn. Nutr. Metab. 2011, 58(2):85-93en_GB
dc.identifier.issn1421-9697-
dc.identifier.pmid21474925-
dc.identifier.doi10.1159/000324600-
dc.identifier.urihttp://hdl.handle.net/2336/227536-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractBACKGROUND/AIMS: To explore associations between vitamin D and cardiovascular disease risk factors in young European adults. METHODS: This was a cross-sectional analysis of serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone (iPTH) and biomarkers of cardiovascular disease risk in 195 healthy 20- to 40-year-olds (109 women) with a BMI between 27.5 and 32.5 from Iceland (64° N; n = 82), Ireland (51° N; n = 37) and Spain (42° N; n = 76) during mid-late winter. RESULTS: The median s25(OH)D was 52.8 nmol/l (IQR 38.1-69.9) or 21.1 ng/ml (IQR 15.2-28.0) with a latitude-dependent gradient (p ≤ 0.0001): Iceland, 41.7 nmol/l (IQR 32.7-54.2) or 16.7 ng/ml (IQR 13.1-21.7); Ireland, 52.9 nmol/l (IQR 35.3-68.6) or 21.2 ng/ml (IQR 14.1-27.4), and Spain, 67.1 nmol/l (IQR 47.1-87.1) or 26.8 ng/ml (IQR 18.8-34.8). Eleven percent of Icelandic participants had s25(OH)D concentrations <25 nmol/l (10 ng/ml) and 66% of Icelandic, 43% of Irish, and 30% of Spanish volunteers had concentrations <50 nmol/l (20 ng/ml), respectively. Overall, 17% met 3 or more of the NCEP/ATP III criteria for cardio-metabolic syndrome (MetS). Participants in the lowest third of s25(OH)D [≤ 42.5 nmol/l (17 ng/ml)] were more likely to have MetS (OR 2.49, p = 0.045) and elevated TAG (OR 3.46, p = 0.019). Individuals with iPTH concentrations in the lowest third [2.34 pmol/l (22.2 pg/ml)] were more likely to have elevated fasting TAG (OR 4.17, p = 0.039), insulin (OR 3.15, p = 0.029) and HOMA-IR (OR 2.15, p = 0.031), and they were less likely to have elevated IL-6 (OR 0.24, p = 0.003). CONCLUSION: There were interactions between s25(OH)D, iPTH and cardio-metabolic risk factors which, given the increasing prevalence of overweight and obesity and a low vitamin D status among adults, require randomised controlled vitamin D intervention studies in overweight persons.en_GB
dc.description.sponsorshipEuropean Commission EC2004-506359en_GB
dc.language.isoenen
dc.publisherKargeren_GB
dc.relation.urlhttp://dx.doi.org/10.1159/000324600en_GB
dc.rightsArchived with thanks to Annals of nutrition & metabolismen_GB
dc.subject.mesh25-Hydroxyvitamin D 2en_GB
dc.subject.meshAdulten_GB
dc.subject.meshCalcifediolen_GB
dc.subject.meshCardiovascular Diseasesen_GB
dc.subject.meshCross-Sectional Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypertriglyceridemiaen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshInsulin Resistanceen_GB
dc.subject.meshInterleukin-6en_GB
dc.subject.meshIrelanden_GB
dc.subject.meshMaleen_GB
dc.subject.meshMetabolic Syndrome Xen_GB
dc.subject.meshNutritional Statusen_GB
dc.subject.meshOverweighten_GB
dc.subject.meshParathyroid Hormoneen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSeasonsen_GB
dc.subject.meshSpainen_GB
dc.subject.meshVitamin D Deficiencyen_GB
dc.subject.meshYoung Adulten_GB
dc.titleRelationships between vitamin D status and cardio-metabolic risk factors in young European adults.en
dc.typeArticleen
dc.contributor.departmentVitamin D Research Group, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.en_GB
dc.identifier.journalAnnals of nutrition & metabolismen_GB

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