Increasing incidence of late-onset neonatal invasive group B streptococcal infections in Iceland.

2.50
Hdl Handle:
http://hdl.handle.net/2336/227571
Title:
Increasing incidence of late-onset neonatal invasive group B streptococcal infections in Iceland.
Authors:
Óladóttir, Guđrún Lilja; Erlendsdóttir, Helga; Pálsson, Gestur; Björnsdóttir, Erla Soffía; Kristinsson, Karl G; Haraldsson, Ásgeir
Citation:
Pediatr. Infect. Dis. J. 2011, 30 (8):661-3
Issue Date:
Aug-2011
Abstract:
BACKGROUND: Group B streptococci (GBS) may cause life-threatening invasive infections in infants. The incidence of these infections has been increasing during the last decades. The aim of the study was to determine the epidemiology of neonatal GBS infections to be able to implement therapeutic and preventive measures more effectively. METHODS: A retrospective case study was conducted in Iceland that included all neonates with positive GBS cultures from blood or cerebrospinal fluid during the period 1975 to 2006. Serotyping of all available GBS isolates was performed. RESULTS: A total of 87 children with 89 infections were included in the study. In all, 53 infants had early-onset (EO) GBS infections (occurring <7 days after birth) and 34 had late-onset (LO) infections (occurring on days 7-90). EO infections increased during the first 3 quartiles of the study period but decreased during the last quartile. LO infections increased throughout the entire study period. GBS was cultured from cerebrospinal fluid in 21 patients; 9 with EO and 12 with LO infections. Premature infants comprised 15 with EO and 14 with LO infections. Eight children died of GBS infection, 7 with EO and 1 with LO infections; no correlation with serotypes was found. Serotype III was most common for both EO (34%) and LO infections (62%). CONCLUSION: The number of GBS infections increased during the study period. The decrease in EO infections in recent years could be attributed to intrapartum antibiotic treatment. The increasing number of LO infections is a concern.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links:
http://dx.doi.org/10.1097/INF.0b013e3182184fe4
Rights:
Archived with thanks to The Pediatric infectious disease journal

Full metadata record

DC FieldValue Language
dc.contributor.authorÓladóttir, Guđrún Liljaen_GB
dc.contributor.authorErlendsdóttir, Helgaen_GB
dc.contributor.authorPálsson, Gesturen_GB
dc.contributor.authorBjörnsdóttir, Erla Soffíaen_GB
dc.contributor.authorKristinsson, Karl Gen_GB
dc.contributor.authorHaraldsson, Ásgeiren_GB
dc.date.accessioned2012-06-05T14:16:49Z-
dc.date.available2012-06-05T14:16:49Z-
dc.date.issued2011-08-
dc.date.submitted2012-06-05-
dc.identifier.citationPediatr. Infect. Dis. J. 2011, 30 (8):661-3en_GB
dc.identifier.issn1532-0987-
dc.identifier.pmid21753260-
dc.identifier.doi10.1097/INF.0b013e3182184fe4-
dc.identifier.urihttp://hdl.handle.net/2336/227571-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractBACKGROUND: Group B streptococci (GBS) may cause life-threatening invasive infections in infants. The incidence of these infections has been increasing during the last decades. The aim of the study was to determine the epidemiology of neonatal GBS infections to be able to implement therapeutic and preventive measures more effectively. METHODS: A retrospective case study was conducted in Iceland that included all neonates with positive GBS cultures from blood or cerebrospinal fluid during the period 1975 to 2006. Serotyping of all available GBS isolates was performed. RESULTS: A total of 87 children with 89 infections were included in the study. In all, 53 infants had early-onset (EO) GBS infections (occurring <7 days after birth) and 34 had late-onset (LO) infections (occurring on days 7-90). EO infections increased during the first 3 quartiles of the study period but decreased during the last quartile. LO infections increased throughout the entire study period. GBS was cultured from cerebrospinal fluid in 21 patients; 9 with EO and 12 with LO infections. Premature infants comprised 15 with EO and 14 with LO infections. Eight children died of GBS infection, 7 with EO and 1 with LO infections; no correlation with serotypes was found. Serotype III was most common for both EO (34%) and LO infections (62%). CONCLUSION: The number of GBS infections increased during the study period. The decrease in EO infections in recent years could be attributed to intrapartum antibiotic treatment. The increasing number of LO infections is a concern.en_GB
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen_GB
dc.relation.urlhttp://dx.doi.org/10.1097/INF.0b013e3182184fe4en_GB
dc.rightsArchived with thanks to The Pediatric infectious disease journalen_GB
dc.subject.meshBlooden_GB
dc.subject.meshCerebrospinal Fluiden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIcelanden_GB
dc.subject.meshIncidenceen_GB
dc.subject.meshInfanten_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshMaleen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshSerotypingen_GB
dc.subject.meshStreptococcal Infectionsen_GB
dc.subject.meshStreptococcus agalactiaeen_GB
dc.titleIncreasing incidence of late-onset neonatal invasive group B streptococcal infections in Iceland.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, University of Iceland, Reykjavik, Iceland.en_GB
dc.identifier.journalPediatric infectious disease journalen_GB
All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.