Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study.

2.50
Hdl Handle:
http://hdl.handle.net/2336/240172
Title:
Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study.
Authors:
Knevel, Rachel; Gröndal, Gerður; Huizinga, Tom W J; Visser, A Willemien; Jónsson, Helgi; Víkingsson, Arnór; Geirsson, Arni Jón; Steinsson, Kristján; van der Helm-van Mil, Annette H M
Citation:
Ann. Rheum. Dis. 2012, 71(5):707-9
Issue Date:
May-2012
Abstract:
The susceptibility to rheumatoid arthritis (RA) is partly heritable, but whether the severity of RA is also influenced by genetics has not been determined. The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable. Iceland has an unique comprehensive genealogy database covering today's population and stretching back to ≥1000 years ago, as well as genome-wide single nucleotide polymorphism data for a large part of the population. Hand and feet x-rays of 325 Icelandic patients with RA were scored according to the Sharp-van der Heijde method. The degree of relatedness between patients was estimated in two ways: (1) kinship coefficients (KC) on the genealogical data were expressed; and (2) the identical-by-descent (IBD) was estimated applying long-range phasing of the genetic profile of the patients. The degree of relatedness was tested against the similarity in joint destruction rates by linear regression analysis and the heritability of joint destruction was calculated. Significant associations between degree of relatedness and similarity in joint destruction rates were observed for both methods of determining relatedness (p(KC)=0.018, p(IBD)=0.003). The estimated heritability was 45% using KC and 58% using the estimated IBD data. The severity of joint destruction in RA is influenced by genetic factors.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links:
http://dx.doi.org/10.1136/annrheumdis-2011-200627

Full metadata record

DC FieldValueLanguage
dc.contributor.authorKnevel, Rachelen_GB
dc.contributor.authorGröndal, Gerðuren_GB
dc.contributor.authorHuizinga, Tom W Jen_GB
dc.contributor.authorVisser, A Willemienen_GB
dc.contributor.authorJónsson, Helgien_GB
dc.contributor.authorVíkingsson, Arnóren_GB
dc.contributor.authorGeirsson, Arni Jónen_GB
dc.contributor.authorSteinsson, Kristjánen_GB
dc.contributor.authorvan der Helm-van Mil, Annette H Men_GB
dc.date.accessioned2012-08-28T09:01:19Z-
dc.date.available2012-08-28T09:01:19Z-
dc.date.issued2012-05-
dc.date.submitted2012-08-28-
dc.identifier.citationAnn. Rheum. Dis. 2012, 71(5):707-9en_GB
dc.identifier.issn1468-2060-
dc.identifier.pmid22219137-
dc.identifier.doi10.1136/annrheumdis-2011-200627-
dc.identifier.urihttp://hdl.handle.net/2336/240172-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractThe susceptibility to rheumatoid arthritis (RA) is partly heritable, but whether the severity of RA is also influenced by genetics has not been determined. The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable. Iceland has an unique comprehensive genealogy database covering today's population and stretching back to ≥1000 years ago, as well as genome-wide single nucleotide polymorphism data for a large part of the population. Hand and feet x-rays of 325 Icelandic patients with RA were scored according to the Sharp-van der Heijde method. The degree of relatedness between patients was estimated in two ways: (1) kinship coefficients (KC) on the genealogical data were expressed; and (2) the identical-by-descent (IBD) was estimated applying long-range phasing of the genetic profile of the patients. The degree of relatedness was tested against the similarity in joint destruction rates by linear regression analysis and the heritability of joint destruction was calculated. Significant associations between degree of relatedness and similarity in joint destruction rates were observed for both methods of determining relatedness (p(KC)=0.018, p(IBD)=0.003). The estimated heritability was 45% using KC and 58% using the estimated IBD data. The severity of joint destruction in RA is influenced by genetic factors.en_GB
dc.description.sponsorshipDutch Arthritis Foundation, Reumafonds Netherlands Organisation of Health Research and Development (ZonMw)en_GB
dc.language.isoenen
dc.publisherBMJ Publishing Groupen_GB
dc.relation.urlhttp://dx.doi.org/10.1136/annrheumdis-2011-200627en_GB
dc.rightsArchived with thanks to Annals of the rheumatic diseasesen_GB
dc.subject.meshArthritis, Rheumatoiden_GB
dc.subject.meshConsanguinityen_GB
dc.subject.meshDatabases, Factualen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGenetic Predisposition to Diseaseen_GB
dc.subject.meshGenome-Wide Association Studyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshJointsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPolymorphism, Single Nucleotideen_GB
dc.subject.meshPopulation Surveillanceen_GB
dc.titleGenetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study.en
dc.typeArticleen
dc.contributor.departmentLandspitali The National University Hospital, Reykjavík, Iceland. Leiden University Medical Center, The Netherlands.en_GB
dc.identifier.journalAnnals of the rheumatic diseasesen_GB
dc.rights.accessLandspitali Access - LSH-aðganguren
dc.type.categoryGigtlæknisfræðien_GB

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