The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the Icelandic Sleep Apnea Cohort.

2.50
Hdl Handle:
http://hdl.handle.net/2336/253294
Title:
The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the Icelandic Sleep Apnea Cohort.
Authors:
Arnardottir, Erna S; Maislin, Greg; Schwab, Richard J; Staley, Bethany; Benediktsdottir, Bryndis; Olafsson, Isleifur; Juliusson, Sigurdur; Romer, Micah; Gislason, Thorarinn; Pack, Allan I
Citation:
Sleep 2012, 35(7):921-32
Issue Date:
1-Jul-2012
Abstract:
STUDY OBJECTIVES: To assess the relative roles and interaction of obstructive sleep apnea (OSA) severity and obesity on interleukin-6 (IL-6) and C-reactive protein (CRP) levels. DESIGN: Cross-sectional cohort. SETTING: The Icelandic Sleep Apnea Cohort. PARTICIPANTS: 454 untreated OSA patients (380 males and 74 females), mean ± standard deviation age 54.4 ± 10.6 yr. MEASUREMENTS AND RESULTS: Participants underwent a sleep study, abdominal magnetic resonance imaging to measure total abdominal and visceral fat volume, and had fasting morning IL-6 and CRP levels measured in serum. A significantly higher correlation was found for BMI than visceral fat volume with CRP and IL-6 levels. Oxygen desaturation index, hypoxia time, and minimum oxygen saturation (SaO₂) significantly correlated with IL-6 and CRP levels, but apnea-hypopnea index did not. When stratified by body mass index (BMI) category, OSA severity was associated with IL-6 levels in obese participants only (BMI > 30 kg/m²). A multiple linear regression model with interaction terms showed an independent association of OSA severity with IL-6 levels and an interaction between OSA severity and BMI, i.e., degree of obesity altered the relationship between OSA and IL-6 levels. An independent association of OSA severity with CRP levels was found for minimum SaO₂ only. A similar interaction of OSA severity and BMI on CRP levels was found for males and postmenopausal women. CONCLUSIONS: OSA severity is an independent predictor of levels of IL-6 and CRP but interacts with obesity such that this association is found only in obese patients.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.
Additional Links:
http://dx.doi.org/10.5665/sleep.1952

Full metadata record

DC FieldValue Language
dc.contributor.authorArnardottir, Erna Sen_GB
dc.contributor.authorMaislin, Gregen_GB
dc.contributor.authorSchwab, Richard Jen_GB
dc.contributor.authorStaley, Bethanyen_GB
dc.contributor.authorBenediktsdottir, Bryndisen_GB
dc.contributor.authorOlafsson, Isleifuren_GB
dc.contributor.authorJuliusson, Sigurduren_GB
dc.contributor.authorRomer, Micahen_GB
dc.contributor.authorGislason, Thorarinnen_GB
dc.contributor.authorPack, Allan Ien_GB
dc.date.accessioned2012-11-26T09:26:30Z-
dc.date.available2012-11-26T09:26:30Z-
dc.date.issued2012-07-01-
dc.identifier.citationSleep 2012, 35(7):921-32en_GB
dc.identifier.issn1550-9109-
dc.identifier.pmid22754038-
dc.identifier.doi10.5665/sleep.1952-
dc.identifier.urihttp://hdl.handle.net/2336/253294-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field.en_GB
dc.description.abstractSTUDY OBJECTIVES: To assess the relative roles and interaction of obstructive sleep apnea (OSA) severity and obesity on interleukin-6 (IL-6) and C-reactive protein (CRP) levels. DESIGN: Cross-sectional cohort. SETTING: The Icelandic Sleep Apnea Cohort. PARTICIPANTS: 454 untreated OSA patients (380 males and 74 females), mean ± standard deviation age 54.4 ± 10.6 yr. MEASUREMENTS AND RESULTS: Participants underwent a sleep study, abdominal magnetic resonance imaging to measure total abdominal and visceral fat volume, and had fasting morning IL-6 and CRP levels measured in serum. A significantly higher correlation was found for BMI than visceral fat volume with CRP and IL-6 levels. Oxygen desaturation index, hypoxia time, and minimum oxygen saturation (SaO₂) significantly correlated with IL-6 and CRP levels, but apnea-hypopnea index did not. When stratified by body mass index (BMI) category, OSA severity was associated with IL-6 levels in obese participants only (BMI > 30 kg/m²). A multiple linear regression model with interaction terms showed an independent association of OSA severity with IL-6 levels and an interaction between OSA severity and BMI, i.e., degree of obesity altered the relationship between OSA and IL-6 levels. An independent association of OSA severity with CRP levels was found for minimum SaO₂ only. A similar interaction of OSA severity and BMI on CRP levels was found for males and postmenopausal women. CONCLUSIONS: OSA severity is an independent predictor of levels of IL-6 and CRP but interacts with obesity such that this association is found only in obese patients.en_GB
dc.description.sponsorshipNIH HL072067 HL094307 University of Iceland Landspitali University Hospitalen_GB
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.5665/sleep.1952en_GB
dc.rightsArchived with thanks to Sleepen_GB
dc.subject.meshAbdominal Faten_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshBody Mass Indexen_GB
dc.subject.meshC-Reactive Proteinen_GB
dc.subject.meshCross-Sectional Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInterleukin-6en_GB
dc.subject.meshIntra-Abdominal Faten_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshObesityen_GB
dc.subject.meshSleep Apnea, Obstructiveen_GB
dc.titleThe interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the Icelandic Sleep Apnea Cohort.en
dc.typeArticleen
dc.contributor.departmentDepartment of Respiratory Medicine and Sleep, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.en_GB
dc.identifier.journalSleepen_GB
dc.rights.accessOpen Access - Opinn aðganguren
dc.type.categoryLungnasjúkdómar, JJJen_GB

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