C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study

2.50
Hdl Handle:
http://hdl.handle.net/2336/2657
Title:
C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study
Authors:
Olafsdottir, I S; Gislason, T; Thjodleifsson, B; Olafsson, I; Gislason, D; Jögi, R; Janson, C
Citation:
Thorax 2005, 60(6):451-4
Issue Date:
1-Jun-2005
Abstract:
BACKGROUND: High sensitivity C reactive protein (HsCRP) is an inflammatory marker known to be related to smoking, obesity, and cardiovascular disease. A study was undertaken to determine whether HsCRP is related to respiratory symptoms, asthma, atopy, and bronchial hyperresponsiveness in population samples from three countries. METHODS: HsCRP was measured in 1289 subjects from three centres in ECRHS II: Reykjavik, Uppsala and Tartu. The HsCRP values ranged from <0.01 mg/l to 70.0 mg/l and were divided into four equal groups (< or = 0.45, 0.46-0.96, 0.97-2.21, and >2.21 mg/l). RESULTS: HsCRP increased with increasing body mass index (r = 0.41; p<0.0001) and was higher in smokers than in never smokers (p = 0.02). A significant relationship was found between increased HsCRP levels and respiratory symptoms such as wheeze, attacks of breathlessness after effort, and nocturnal cough (p<0.0001). The crude odds ratio (95% CI) for the probability of non-allergic asthma was 3.57 (1.83 to 6.96) for subjects in the 4th quartile compared with the 1st quartile of HsCRP. This association remained significant after adjusting for study centre, age, sex, body weight, and smoking history (OR 2.19 (95% CI 1.04 to 4.63)). No significant relationship was observed between HsCRP and allergic asthma or bronchial responsiveness. CONCLUSIONS: Raised levels of HsCRP are significantly associated with respiratory symptoms and non-allergic asthma but not with allergic asthma.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://thorax.bmjjournals.com/cgi/reprint/60/6/451

Full metadata record

DC FieldValue Language
dc.contributor.authorOlafsdottir, I S-
dc.contributor.authorGislason, T-
dc.contributor.authorThjodleifsson, B-
dc.contributor.authorOlafsson, I-
dc.contributor.authorGislason, D-
dc.contributor.authorJögi, R-
dc.contributor.authorJanson, C-
dc.date.accessioned2006-05-15T15:02:55Z-
dc.date.available2006-05-15T15:02:55Z-
dc.date.issued2005-06-01-
dc.identifier.citationThorax 2005, 60(6):451-4en
dc.identifier.issn0040-6376-
dc.identifier.pmid15923243-
dc.identifier.doi10.1136/thx.2004.035774-
dc.identifier.urihttp://hdl.handle.net/2336/2657-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractBACKGROUND: High sensitivity C reactive protein (HsCRP) is an inflammatory marker known to be related to smoking, obesity, and cardiovascular disease. A study was undertaken to determine whether HsCRP is related to respiratory symptoms, asthma, atopy, and bronchial hyperresponsiveness in population samples from three countries. METHODS: HsCRP was measured in 1289 subjects from three centres in ECRHS II: Reykjavik, Uppsala and Tartu. The HsCRP values ranged from <0.01 mg/l to 70.0 mg/l and were divided into four equal groups (< or = 0.45, 0.46-0.96, 0.97-2.21, and >2.21 mg/l). RESULTS: HsCRP increased with increasing body mass index (r = 0.41; p<0.0001) and was higher in smokers than in never smokers (p = 0.02). A significant relationship was found between increased HsCRP levels and respiratory symptoms such as wheeze, attacks of breathlessness after effort, and nocturnal cough (p<0.0001). The crude odds ratio (95% CI) for the probability of non-allergic asthma was 3.57 (1.83 to 6.96) for subjects in the 4th quartile compared with the 1st quartile of HsCRP. This association remained significant after adjusting for study centre, age, sex, body weight, and smoking history (OR 2.19 (95% CI 1.04 to 4.63)). No significant relationship was observed between HsCRP and allergic asthma or bronchial responsiveness. CONCLUSIONS: Raised levels of HsCRP are significantly associated with respiratory symptoms and non-allergic asthma but not with allergic asthma.en
dc.language.isoenen
dc.publisherBritish Medical Assn.en
dc.relation.urlhttp://thorax.bmjjournals.com/cgi/reprint/60/6/451en
dc.subjectAsthmaen
dc.subjectC-Reactive Proteinen
dc.subjectBronchial Hyperreactivityen
dc.subjectDyspneaen
dc.subjectSmokingen
dc.subjectRespiration Disordersen
dc.titleC reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological studyen
dc.typeArticleen
dc.format.digYES-

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