The association between glucose abnormalities and heart failure in the population-based Reykjavik study

2.50
Hdl Handle:
http://hdl.handle.net/2336/2706
Title:
The association between glucose abnormalities and heart failure in the population-based Reykjavik study
Authors:
Thrainsdottir, Inga S; Aspelund, Thor; Thorgeirsson, Gudmundur; Gudnason, Vilmundur; Hardarson, Thordur; Malmberg, Klas; Sigurdsson, Gunnar; Rydén, Lars
Citation:
Diabetes Care 2005, 28(3):612-6
Issue Date:
1-Mar-2005
Abstract:
OBJECTIVE: Diabetes is an independent risk factor for heart failure, whereas the relation between heart failure and abnormal glucose regulation (AGR) needs further evaluation. We studied this combination in the Reykjavik Study. RESEARCH DESIGN AND METHODS: The Reykjavik Study, a population-based cohort study during 1967-1997, recruited 19,381 participants aged 33-84 years who were followed until 2002. Oral glucose tolerance tests and chest X-rays were obtained from all participants. Cases were defined in accordance with World Health Organization criteria for type 2 diabetes or AGR (impaired glucose tolerance or impaired fasting glucose) and European Society of Cardiology guidelines for heart failure. RESULTS: The overall prevalence of type 2 diabetes and heart failure was 0.5% in men and 0.4% in women, while AGR and heart failure were found in 0.7% of men and 0.6% of women. Among participants with normal glucose regulation, heart failure was diagnosed in 3.2% compared with 6.0 and 11.8% among those with AGR and type 2 diabetes, respectively. The prevalence of type 2 diabetes in the age-group 45-65 years increased in both sexes during the period (P for trend = 0.007). The odds ratio was 2.8 (95% CI 2.2-3.6) for the association between type 2 diabetes and heart failure and 1.7 (1.4-2.1) between AGR and heart failure. CONCLUSIONS: There is a strong association between any form of glucometabolic perturbation and heart failure. Future studies in this field should focus on all types of glucose abnormalities rather than previously diagnosed diabetes only.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://care.diabetesjournals.org/cgi/content/abstract/28/3/612

Full metadata record

DC FieldValue Language
dc.contributor.authorThrainsdottir, Inga S-
dc.contributor.authorAspelund, Thor-
dc.contributor.authorThorgeirsson, Gudmundur-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorHardarson, Thordur-
dc.contributor.authorMalmberg, Klas-
dc.contributor.authorSigurdsson, Gunnar-
dc.contributor.authorRydén, Lars-
dc.date.accessioned2006-05-16T14:33:25Z-
dc.date.available2006-05-16T14:33:25Z-
dc.date.issued2005-03-01-
dc.identifier.citationDiabetes Care 2005, 28(3):612-6en
dc.identifier.issn0149-5992-
dc.identifier.pmid15735197-
dc.identifier.doi10.2337/diacare.28.3.612-
dc.identifier.otherCAR12en
dc.identifier.urihttp://hdl.handle.net/2336/2706-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractOBJECTIVE: Diabetes is an independent risk factor for heart failure, whereas the relation between heart failure and abnormal glucose regulation (AGR) needs further evaluation. We studied this combination in the Reykjavik Study. RESEARCH DESIGN AND METHODS: The Reykjavik Study, a population-based cohort study during 1967-1997, recruited 19,381 participants aged 33-84 years who were followed until 2002. Oral glucose tolerance tests and chest X-rays were obtained from all participants. Cases were defined in accordance with World Health Organization criteria for type 2 diabetes or AGR (impaired glucose tolerance or impaired fasting glucose) and European Society of Cardiology guidelines for heart failure. RESULTS: The overall prevalence of type 2 diabetes and heart failure was 0.5% in men and 0.4% in women, while AGR and heart failure were found in 0.7% of men and 0.6% of women. Among participants with normal glucose regulation, heart failure was diagnosed in 3.2% compared with 6.0 and 11.8% among those with AGR and type 2 diabetes, respectively. The prevalence of type 2 diabetes in the age-group 45-65 years increased in both sexes during the period (P for trend = 0.007). The odds ratio was 2.8 (95% CI 2.2-3.6) for the association between type 2 diabetes and heart failure and 1.7 (1.4-2.1) between AGR and heart failure. CONCLUSIONS: There is a strong association between any form of glucometabolic perturbation and heart failure. Future studies in this field should focus on all types of glucose abnormalities rather than previously diagnosed diabetes only.en
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.relation.urlhttp://care.diabetesjournals.org/cgi/content/abstract/28/3/612en
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBlood Glucoseen
dc.subjectDiabetes Mellitusen
dc.subjectDiabetes Mellitus, Type 2en
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIceland/epidemiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrevalenceen
dc.subjectReference Valuesen
dc.subject.meshHeart Failure, Congestiveen
dc.subject.meshDiabetic Angiopathiesen
dc.titleThe association between glucose abnormalities and heart failure in the population-based Reykjavik studyen
dc.typeArticleen
dc.identifier.journalDiabetes careen
dc.format.digYES-

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