An increase in bronchial responsiveness is associated with continuing or restarting smoking

2.50
Hdl Handle:
http://hdl.handle.net/2336/2763
Title:
An increase in bronchial responsiveness is associated with continuing or restarting smoking
Authors:
Chinn, Susan; Jarvis, Deborah; Luczynska, Christina M; Ackermann-Liebrich, Ursula; Antó, Josep M; Cerveri, Isa; de Marco, Roberto; Gislason, Thorarinn; Heinrich, Joachim; Janson, Christer; Künzli, Nino; Leynaert, Bénédicte; Neukirch, Françoise; Schouten, Jan P; Sunyer, Jordi; Svanes, Cecilie; Wjst, Matthias; Burney, Peter G
Citation:
Am. J. Respir. Crit. Care Med. 2005, 172(8):956-61
Issue Date:
15-Oct-2005
Abstract:
RATIONALE: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. OBJECTIVES: To analyze change in bronchial responsiveness in an international longitudinal community study. METHODS: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002. MEASUREMENTS: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex. MAIN RESULTS: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD20 of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV1. No other risk factor for change in bronchial responsiveness was identified. CONCLUSIONS: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://ajrccm.atsjournals.org/cgi/content/full/172/8/956

Full metadata record

DC FieldValue Language
dc.contributor.authorChinn, Susan-
dc.contributor.authorJarvis, Deborah-
dc.contributor.authorLuczynska, Christina M-
dc.contributor.authorAckermann-Liebrich, Ursula-
dc.contributor.authorAntó, Josep M-
dc.contributor.authorCerveri, Isa-
dc.contributor.authorde Marco, Roberto-
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorJanson, Christer-
dc.contributor.authorKünzli, Nino-
dc.contributor.authorLeynaert, Bénédicte-
dc.contributor.authorNeukirch, Françoise-
dc.contributor.authorSchouten, Jan P-
dc.contributor.authorSunyer, Jordi-
dc.contributor.authorSvanes, Cecilie-
dc.contributor.authorWjst, Matthias-
dc.contributor.authorBurney, Peter G-
dc.date.accessioned2006-05-17T12:50:37Z-
dc.date.available2006-05-17T12:50:37Z-
dc.date.issued2005-10-15-
dc.identifier.citationAm. J. Respir. Crit. Care Med. 2005, 172(8):956-61en
dc.identifier.issn1073-449X-
dc.identifier.pmid16020802-
dc.identifier.doi10.1164/rccm.200503-323OC-
dc.identifier.otherPAD12en
dc.identifier.urihttp://hdl.handle.net/2336/2763-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractRATIONALE: Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults. OBJECTIVES: To analyze change in bronchial responsiveness in an international longitudinal community study. METHODS: The study was performed in 3,993 participants in the European Community Respiratory Health Survey who had bronchial responsiveness measured in 1991-1993, when aged 20 to 44 yr, and in 1998-2002. MEASUREMENTS: Bronchial responsiveness was assessed by methacholine challenge. Serum samples were tested for total IgE, and for specific IgE to four common allergens. Smoking information was obtained from detailed administered questionnaires. Change in bronchial responsiveness was analyzed by change in IgE sensitization, smoking, and lung function, with tests of interaction terms with age and sex. MAIN RESULTS: Continuing and restarting smokers had increasing bronchial responsiveness, approximately equivalent to a mean reduction in PD20 of 0.68 and 0.75 doubling doses, respectively, over 10 yr, in addition to a small increase explained by decline in FEV1. No other risk factor for change in bronchial responsiveness was identified. CONCLUSIONS: Smoking is a risk factor for increasing bronchial responsiveness over and above the effect of decreasing lung function. Neither baseline IgE sensitization nor change in sensitization was shown to be a risk factor for increasing BHR, the latter possibly due to little overall increase or decrease in sensitization.en
dc.language.isoenen
dc.publisherAmerican Thoracic Societyen
dc.relation.urlhttp://ajrccm.atsjournals.org/cgi/content/full/172/8/956en
dc.subjectAdulten
dc.subjectAge Distributionen
dc.subjectBronchial Hyperreactivityen
dc.subjectBronchial Provocation Testsen
dc.subjectBronchoconstrictor Agentsen
dc.subjectEurope/epidemiologyen
dc.subjectFemaleen
dc.subjectForced Expiratory Volumeen
dc.subjectHumansen
dc.subjectHypersensitivity, Immediateen
dc.subjectImmunoglobulin Een
dc.subjectLongitudinal Studiesen
dc.subjectMaleen
dc.subjectMeta-Analysisen
dc.subjectMethacholine Chlorideen
dc.subjectQuestionnairesen
dc.subjectRecurrenceen
dc.subjectRegression Analysisen
dc.subjectRisk Factorsen
dc.subjectSex Distributionen
dc.subjectSmokingen
dc.subjectTime Factorsen
dc.subjectUnited States/epidemiologyen
dc.titleAn increase in bronchial responsiveness is associated with continuing or restarting smokingen
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.