2.50
Hdl Handle:
http://hdl.handle.net/2336/2775
Title:
Change in prevalence of IgE sensitization and mean total IgE with age and cohort
Authors:
Jarvis, Deborah; Luczynska, Christina; Chinn, Susan; Potts, James; Sunyer, Jordi; Janson, Christer; Svanes, Cecilie; Künzli, Nino; Leynaert, Bénédicte; Heinrich, Joachim; Kerkhof, Marjan; Ackermann-Liebrich, Ursula; Antó, Josep M; Cerveri, Isa; de Marco, Roberto; Gislason, Thorarinn; Neukirch, Françoise; Vermeire, Paul; Wjst, Matthias; Burney, Peter
Citation:
J. Allergy Clin. Immunol. 2005, 116(3):675-82
Issue Date:
1-Sep-2005
Abstract:
BACKGROUND: Cross-sectional studies show that the prevalence of IgE sensitization is lower in older age groups than younger age groups. This could reflect either a decrease in sensitization with aging or a higher prevalence of sensitization in more recent birth cohorts. OBJECTIVE: To assess change in IgE sensitization and mean total IgE in young adults as they age. METHODS: Serum specific IgE to common allergens and total IgE were measured on 2 occasions about 9 years apart in 6371 young adults living in 28 centers, mainly in Western Europe, who took part in the European Community Respiratory Health Survey II. Outcomes were analyzed by using generalized estimating equations, and adjustments were made for differences between laboratory measures on the 2 occasions. RESULTS: Overall, there was no net change in the prevalence of sensitization to at least 1 of house dust mite, grass, or cat (net change per 10 years of follow-up, -0.1%; 95% CI, -1.7% to 1.5%), although there was a fall in mean total IgE (ratio of geometric mean total IgE, 0.86; 95% CI, 0.79 to 0.93). There was evidence that sensitization to at least 1 allergen was higher in more recent cohorts, and this was largely explained by a higher prevalence of sensitization to grass. CONCLUSION: The disease burden associated with IgE sensitization in adults, and particularly with IgE sensitization to grass, is likely to continue to increase for some time despite current evidence that the increase in allergy seen in children may have ceased.
Additional Links:
http://www.sciencedirect.com/science/article/B6WH4-4GMGW5K-2/2/b707df9a484610674a60faae327d6742

Full metadata record

DC FieldValue Language
dc.contributor.authorJarvis, Deborah-
dc.contributor.authorLuczynska, Christina-
dc.contributor.authorChinn, Susan-
dc.contributor.authorPotts, James-
dc.contributor.authorSunyer, Jordi-
dc.contributor.authorJanson, Christer-
dc.contributor.authorSvanes, Cecilie-
dc.contributor.authorKünzli, Nino-
dc.contributor.authorLeynaert, Bénédicte-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorKerkhof, Marjan-
dc.contributor.authorAckermann-Liebrich, Ursula-
dc.contributor.authorAntó, Josep M-
dc.contributor.authorCerveri, Isa-
dc.contributor.authorde Marco, Roberto-
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorNeukirch, Françoise-
dc.contributor.authorVermeire, Paul-
dc.contributor.authorWjst, Matthias-
dc.contributor.authorBurney, Peter-
dc.date.accessioned2006-05-17T13:57:27Z-
dc.date.available2006-05-17T13:57:27Z-
dc.date.issued2005-09-01-
dc.identifier.citationJ. Allergy Clin. Immunol. 2005, 116(3):675-82en
dc.identifier.issn0091-6749-
dc.identifier.pmid16159642-
dc.identifier.doi10.1016/j.jaci.2005.05.009-
dc.identifier.urihttp://hdl.handle.net/2336/2775-
dc.description.abstractBACKGROUND: Cross-sectional studies show that the prevalence of IgE sensitization is lower in older age groups than younger age groups. This could reflect either a decrease in sensitization with aging or a higher prevalence of sensitization in more recent birth cohorts. OBJECTIVE: To assess change in IgE sensitization and mean total IgE in young adults as they age. METHODS: Serum specific IgE to common allergens and total IgE were measured on 2 occasions about 9 years apart in 6371 young adults living in 28 centers, mainly in Western Europe, who took part in the European Community Respiratory Health Survey II. Outcomes were analyzed by using generalized estimating equations, and adjustments were made for differences between laboratory measures on the 2 occasions. RESULTS: Overall, there was no net change in the prevalence of sensitization to at least 1 of house dust mite, grass, or cat (net change per 10 years of follow-up, -0.1%; 95% CI, -1.7% to 1.5%), although there was a fall in mean total IgE (ratio of geometric mean total IgE, 0.86; 95% CI, 0.79 to 0.93). There was evidence that sensitization to at least 1 allergen was higher in more recent cohorts, and this was largely explained by a higher prevalence of sensitization to grass. CONCLUSION: The disease burden associated with IgE sensitization in adults, and particularly with IgE sensitization to grass, is likely to continue to increase for some time despite current evidence that the increase in allergy seen in children may have ceased.en
dc.language.isoenen
dc.publisherMosbyen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WH4-4GMGW5K-2/2/b707df9a484610674a60faae327d6742en
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAnimalsen
dc.subjectCats/immunologyen
dc.subjectCohort Studiesen
dc.subjectComparative Studyen
dc.subjectDermatophagoides pteronyssinusen
dc.subjectEuropeen
dc.subjectHumansen
dc.subjectLongitudinal Studiesen
dc.subjectPoaceaeen
dc.subjectPrevalenceen
dc.subject.meshHypersensitivityen
dc.titleChange in prevalence of IgE sensitization and mean total IgE with age and cohorten
dc.typeArticleen
dc.identifier.journalJournal of allergy and clinical immunologyen
dc.format.digYES-

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