Effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa

2.50
Hdl Handle:
http://hdl.handle.net/2336/2789
Title:
Effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa
Authors:
Rindi, Guido; Fiocca, Roberto; Morocutti, Anna; Jacobs, Adam; Miller, Neil; Thjodleifsson, Bjarni
Citation:
Eur J Gastroenterol Hepatol 2005, 17(5):559-66
Issue Date:
1-May-2005
Abstract:
BACKGROUND: Prolonged gastric acid suppression leads to hypergastrinaemia, which promotes hyperplasia of the enterochromaffin-like (ECL) cells of the oxyntic mucosa. The objective was to determine the effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa. METHODS: Two hundred and forty-three patients received rabeprazole (20 mg or 10 mg) or omeprazole (20 mg) once daily for up to 5 years, for gastro-oesophageal reflux disease and 51% completed the whole 5 year period. Gastric biopsy specimens were taken and examined for gastritis, Helicobacter pylori infection, and ECL cell status. FINDINGS: H. pylori infection in the gastric corpus was more common than in the antrum, and remained constant, whereas antral H. pylori infection became less common as the study progressed. H. pylori infection was a highly significant predictor of higher gastritis scores, which were similar among the three treatment groups. ECL cell hyperplasia occurred in a minority of patients, and was associated with serum gastrin concentrations. No ECL cell dysplasia or tumours were observed. There were no significant differences among the treatment groups in gastritis or ECL cell hyperplasia grades. INTERPRETATION: This study has confirmed the link between ECL cell hyperplasia and elevated serum gastrin concentrations, but has found no evidence that this progresses to high grades of hyperplasia during 5 years of treatment with rabeprazole or omeprazole.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://gateway.ut.ovid.com/gw2/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00042737-200505000-00013&NEWS=N&CSC=Y&CHANNEL=PubMed

Full metadata record

DC FieldValue Language
dc.contributor.authorRindi, Guido-
dc.contributor.authorFiocca, Roberto-
dc.contributor.authorMorocutti, Anna-
dc.contributor.authorJacobs, Adam-
dc.contributor.authorMiller, Neil-
dc.contributor.authorThjodleifsson, Bjarni-
dc.date.accessioned2006-05-17T14:53:51Z-
dc.date.available2006-05-17T14:53:51Z-
dc.date.issued2005-05-01-
dc.identifier.citationEur J Gastroenterol Hepatol 2005, 17(5):559-66en
dc.identifier.issn0954-691X-
dc.identifier.pmid15827447-
dc.identifier.otherGAS12en
dc.identifier.urihttp://hdl.handle.net/2336/2789-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Prolonged gastric acid suppression leads to hypergastrinaemia, which promotes hyperplasia of the enterochromaffin-like (ECL) cells of the oxyntic mucosa. The objective was to determine the effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa. METHODS: Two hundred and forty-three patients received rabeprazole (20 mg or 10 mg) or omeprazole (20 mg) once daily for up to 5 years, for gastro-oesophageal reflux disease and 51% completed the whole 5 year period. Gastric biopsy specimens were taken and examined for gastritis, Helicobacter pylori infection, and ECL cell status. FINDINGS: H. pylori infection in the gastric corpus was more common than in the antrum, and remained constant, whereas antral H. pylori infection became less common as the study progressed. H. pylori infection was a highly significant predictor of higher gastritis scores, which were similar among the three treatment groups. ECL cell hyperplasia occurred in a minority of patients, and was associated with serum gastrin concentrations. No ECL cell dysplasia or tumours were observed. There were no significant differences among the treatment groups in gastritis or ECL cell hyperplasia grades. INTERPRETATION: This study has confirmed the link between ECL cell hyperplasia and elevated serum gastrin concentrations, but has found no evidence that this progresses to high grades of hyperplasia during 5 years of treatment with rabeprazole or omeprazole.en
dc.language.isoenen
dc.publisherLippincott Williams And Wilkinsen
dc.relation.urlhttp://gateway.ut.ovid.com/gw2/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00042737-200505000-00013&NEWS=N&CSC=Y&CHANNEL=PubMeden
dc.subjectAdulten
dc.subjectAnti-Ulcer Agentsen
dc.subjectBenzimidazolesen
dc.subjectBiopsyen
dc.subjectComparative Studyen
dc.subjectDisease Progressionen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDouble-Blind Methoden
dc.subjectGastric Mucosaen
dc.subjectGastrinsen
dc.subjectGastritisen
dc.subjectGastroesophageal Refluxen
dc.subjectHelicobacter Infectionsen
dc.subjectHelicobacter pylorien
dc.subjectHyperplasiaen
dc.subjectMetaplasiaen
dc.subjectOmeprazoleen
dc.subjectProspective Studiesen
dc.subjectProton Pumpsen
dc.subjectSeverity of Illness Indexen
dc.titleEffects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosaen
dc.typeArticleen
dc.identifier.journalEuropean journal of gastroenterology & hepatologyen
dc.format.digYES-

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